The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Microbiological diagnosis of adult tuberculous meningitis in a ten-year cohort in Indonesia
Open accessAbstract
We evaluated microbiological diagnosis of tuberculous (TB) meningitis in a referral hospital in Indonesia. Over a ten-year period, we examined cerebrospinal fluid (CSF) samples of 1180 adult meningitis suspects. Sensitivity of different methods was compared, and results were stratified for HIV status, disease severity, and CSF volume. TB meningitis was bacteriologically confirmed in 501 patients. Using clinical diagnosis as reference standard (n = 713), sensitivity of different methods was 12.2% (86/703) for microscopy, 42% (73/174) for Xpert MTB/RIF, 46.0% (163/354) for solid culture, 48.8% (332/680) for liquid culture, and 64.0% (212/331) for in-house PCR. Head to head comparisons in 654 patients showed a higher yield of in-house PCR (32.3%) compared to culture (15.6%, P < 0.01). Microscopic observation of drug susceptibility (MODS) culture more rapidly became positive compared to other culture methods. Yield of culture was lower in HIV-infected (39/105) than in HIV-negative patients (N = 316/585; P < 0.01). Molecular and culture methods gave higher yields in patients with more severe disease (P < 0.01). CSF volume of ≥6 ml increased the yield of culture (42.8% versus 12.1% for CSF <6 ml, P < 0.01) and ZN-microscopy (18.3% versus 1.9% for CSF <6 ml, P < 0.01). CSF centrifugation had no clear effect on sensitivity of Xpert MTB/RIF. ZN-microscopy lacks sensitivity for diagnosis of TB meningitis. For molecular assays, in-house IS6110-PCR is more sensitive than Xpert MTB/RIF. MODS culture has a clear advantage in terms of speed. Large CSF volumes are necessary for all tests. The effect of CSF processing for Xpert MTB/RIF needs further study.
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“Several studies, with sample sizes ranging from 13 to 102 definite tuberculous meningitis patients and 17 to 127 controls, studied the performance of IS6110 PCR and reported a sensitivity between 72% and 100% (median 91%) with a specificity between 82% and 100% (median 99%) (73–78).”
From Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections (2024) · cites this paper as [74]
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Denkinger, C. M., Schumacher, S. G., Boehme, C. C., Dendukuri, N., Pai, M., & Steingart, K. R. (2014) · European Respiratory Journal · doi:10.1183/09031936.00007814 · Cited by 527
Pai, M., Flores, L. L., Pai, N., Hubbard, A., Riley, L. W., & Colford, J. M. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00772-2 · Cited by 384
Improving the Bacteriological Diagnosis of Tuberculous Meningitis
Thwaites, G. E., Chau, T. T. H., & Farrar, J. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.1.378-379.2004 · Cited by 286
Neurological aspects of tropical disease: Tuberculous meningitis
Thwaites, G. E. (2000) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.68.3.289 · Cited by 274
Evaluation of GeneXpert MTB/RIF for Diagnosis of Tuberculous Meningitis
Nhu, N. T. Q., Heemskerk, D., Thu, D. D. A., Chau, T. T. H., Mai, N. T. H., Nghia, H. D. T., Loc, P. P., Ha, D. T. M., Merson, L., Thinh, T. T. V., et al. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01834-13 · Cited by 244
Patel, V. B., Theron, G., Lenders, L., Matinyena, B., Connolly, C., Singh, R., Coovadia, Y., Ndung'u, T., & Dheda, K. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001536 · Cited by 179
Improved diagnostic sensitivity for tuberculous meningitis with Xpert® MTB/RIF of centrifuged CSF
Bahr, N. C., Tugume, L., Rajasingham, R., Kiggundu, R., Williams, D. A., Morawski, B. M., Alland, D., Meya, D. B., Rhein, J., & Boulware, D. R. (2015) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.15.0253 · Cited by 115
Diagnosing tuberculous meningitis – have we made any progress?
Ho, J., Marais, B. J., Gilbert, G. L., & Ralph, A. P. (2013) · Tropical Medicine & International Health · doi:10.1111/tmi.12099 · Cited by 65
Chaidir, L., Ganiem, A. R., Zanden, A. V., Muhsinin, S., Kusumaningrum, T., Kusumadewi, I., van der Ven, A. J. A. M., Alisjahbana, B., Parwati, I., & van Crevel, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052001 · Cited by 61
Self-citationSavelkoul, P. H. M., Catsburg, A., Mulder, S., Oostendorp, L., Schirm, J., Wilke, H., van der Zanden, A. G. M., & Noordhoek, G. T. (2006) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2005.12.003 · Cited by 56
Research works printed but not linked: 1
- Thwaites, 2014, Tuberculous meningitis, Medicine, 41, 3
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Kohli, M., Schiller, I., Dendukuri, N., Yao, M., Dheda, K., Denkinger, C. M., Schumacher, S. G., & Steingart, K. R. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012768.pub3 · Cited by 215
Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections
Olie, S. E., Andersen, C. Ø., van de Beek, D., & Brouwer, M. C. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-24 · Cited by 38
Metadata
- Authors
- Chaidir, L., Annisa, J., Dian, S., Parwati, I., Alisjahbana, A., Purnama, F., van der Zanden, A., Ganiem, A. R., & van Crevel, R.
- Affiliations
- Dr. Hasan Sadikin General Hospital (ID)
- Corresponding author
- Chaidir, Lidya
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 91
- Issue
- 1
- Pages
- 42-46
- ISSN
- 0732-8893 (ISSN-L)
- OpenAlex
- W2783415049
- Cited by
- 34
- References
- 22
- Citations by year
- 2024: 5 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 5
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Diagnostic Microbiology and Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- European Commission
- Koninklijke Nederlandse Akademie van Wetenschappen
- Radboud Universiteit
- Radboud Universitair Medisch Centrum
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Keywords
- tuberculous meningitis, microbiological diagnosis, cerebrospinal fluid, Xpert MTB/RIF, IS6110 PCR, Ziehl-Neelsen microscopy, liquid culture, solid culture, HIV coinfection, disease severity, CSF volume, diagnostic sensitivity, adult patients
- MeSH terms
- Adult, Humans, Indonesia, Microscopy, Mycobacterium tuberculosis, Tuberculosis, Meningeal, Cohort Studies, HIV Infections, Polymerase Chain Reaction, Young Adult
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