Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver
Open accessAbstract
Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis, apoptosis, inflammation and cell-cycle control. Therefore, they play important roles in the pathomechanisms of autoimmune, inflammatory and degenerative diseases, many of which affect the gastrointestinal system. Transglutaminase 2 is prominent, since it is central to the pathogenesis of celiac disease, and modulates inflammation and fibrosis in inflammatory bowel and chronic liver diseases. This review highlights our present understanding of transglutaminase function in gastrointestinal and liver diseases and therapeutic strategies that target transglutaminase activities.
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Some phagocytosis genes (Serpine1, Tgm2) have been previously implicated in liver fibrosis, while others (Cd14, Marco, Csf1) have not been investigated.
“Some of these genes have been previously implicated in liver fibrosis (Serpine133, Tgm234), while role of others (Cd14, Marco, Csf1) have not been investigated to date.”
From Hepatocyte mitochondria-derived danger signals directly activate hepatic stellate cells and drive progression of liver fibrosis (2020) · cites this paper as [34]
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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
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An, P., Wei, L.-L., Zhao, S., Sverdlov, D. Y., Vaid, K. A., Miyamoto, M., Kuramitsu, K., Lai, M., & Popov, Y. V. (2020) · Nature Communications · doi:10.1038/s41467-020-16092-0 · Cited by 319 · see citing works
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- Authors
- Elli, L., Bergamini, C. M., Bardella, M. T., & Schuppan, D.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Ferrara (IT)
- University of Milan (IT)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Elli, L.
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 41
- Issue
- 8
- Pages
- 541-550
- ISSN
- 1590-8658 (ISSN-L)
- OpenAlex
- W2028622825
- Cited by
- 145
- References
- 1
- Citations by year
- 2026: 3 · 2024: 6 · 2023: 58 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 6 · 2012: 12
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Digestive and Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (other-oa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Blood properties and coagulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- transglutaminase, tissue transglutaminase, inflammation, fibrosis, gastrointestinal diseases, liver disease, celiac disease, inflammatory bowel disease, chronic liver disease, protein cross-linking, deamidation, fibrogenesis, therapeutic target
- MeSH terms
- Protein Glutamine gamma Glutamyltransferase 2, Celiac Disease, Enzyme Activation, Fibrosis, Gastrointestinal Diseases, Humans, Inflammation, Liver Diseases, Transglutaminases, Inflammatory Bowel Diseases, Apoptosis, GTP-Binding Proteins
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