Quality of life in children with celiac disease: A paediatric cross-sectional study
Abstract
Background Few studies investigated factors influencing the quality of life of children with celiac disease on a gluten-free diet. Aims To investigate the impact of the gluten-free diet on the psycho-physical well-being of celiac children. Methods In this cross-sectional study, we interviewed 76 celiac and 143 non-celiac children (2-18 years) by using a non-disease specific questionnaire (Pediatric Quality of Life Inventory Test) and we explored the impact of the diet on social life with an open-ended questionnaire. Scores were compared by Wilcoxon rank-sum test. A quantile regression analysis was used to evaluate the impact of celiac disease on score distribution. Results No significant differences in quality of life were found between the two groups (total score: 84.1 (81.1-87.2) vs 81.5 (79.7-83.4), median (95% CI), patients and controls respectively, p=0.4). Treatment positively affected quality of life in children that showed "intermediate" scores in the Pediatric Quality of Life Inventory Test. Lowest scores were observed in children reporting a higher number of diet difficulties or co-morbidities. Conclusions Although celiac patients showed an overall good quality of life in comparison with a control group, by using appropriate analytical methods we elicited specific factors contributing to a lower quality of life in patients, such as co-morbidities and difficulties with the diet.
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Nine studies found similar health-related quality of life in children with celiac disease as in control children.
“Nine of these studies found similar HRQOL in children with CD as in control children (4, 82, 95, 96, 99, 100, 102, 103, 106).”
From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [99]
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Altobelli, E., Paduano, R., Gentile, T., Caloisi, C., Marziliano, C., Necozione, S., & di Orio, F. (2013) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-11-204 · Cited by 63 · see citing works
Nordyke, K., Norström, F., Lindholm, L., Stenlund, H., Rosén, A., & Ivarsson, A. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-142 · Cited by 57 · see citing works
Myléus, A., Petersen, S., Carlsson, A., Hammarroth, S., Högberg, L., & Ivarsson, A. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-425 · Cited by 37 · see citing works
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ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease.
Mearin, M. L., Agardh, D., Antunes, H., Al‐toma, A., Auricchio, R., Castillejo, G., Catassi, C., Ciacci, C., Discepolo, V., Dolinsek, J., et al. (2022) · Journal of pediatric gastroenterology and nutrition · doi:10.1097/mpg.0000000000003540 · Cited by 186 · see citing works
Self-citationMager, D. R., Marcon, M., Brill, H., Liu, A., Radmanovich, K., Mileski, H., Nasser, R., Alzaben, A., Carroll, M. W., Yap, J., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001873 · Cited by 56 · see citing works
- Authors
- Biagetti, C., Gesuita, R., Gatti, S., & Catassi, C.
- Affiliations
- Marche Polytechnic University (IT)
- Corresponding author
- Biagetti, Chiara
- Gesuita, Rosaria
- Gatti, Simona
- Catassi, Carlo
- Venue
- Digestive and Liver Disease
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 47
- Issue
- 11
- Pages
- 927-932
- ISSN
- 1590-8658 (ISSN-L)
- OpenAlex
- W2109801929
- Cited by
- 46
- References
- 3
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 1
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive and Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Health Sciences › Medicine › Surgery › Eosinophilic Esophagitis
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- celiac disease, quality of life, children, gluten-free diet, PedsQL, comorbidities, social life
- MeSH terms
- Adolescent, Celiac Disease, Child, Child, Preschool, Cross-Sectional Studies, Female, Health Status, Humans, Italy, Male, Quality of Life, Surveys and Questionnaires, Regression Analysis, Case-Control Studies, Diet, Gluten-Free, Social Participation
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