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The 1,2,3-triazole ring as a bioisostere in medicinal chemistry
Open accessAbstract
1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.
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Cited by
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
Bozorov, K., Zhao, J., & Aisa, H. A. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.07.005 · Cited by 854
Cu(I)-Catalyzed Click Chemistry in Glycoscience and Their Diverse Applications
Agrahari, A. K., Bose, P., Jaiswal, M. K., Rajkhowa, S., Singh, A. S., Hotha, S., Mishra, N., & Tiwari, V. K. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00920 · Cited by 445
Lossouarn, A., Renard, P.-Y., & Sabot, C. (2021) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.0c00568 · Cited by 26
Metadata
- Authors
- Bonandi, E., Christodoulou, M. S., Fumagalli, G., Perdicchia, D., Rastelli, G., & Passarella, D.
- Venue
- Drug Discovery Today
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 22
- Issue
- 10
- Pages
- 1572-1581
- ISSN
- 1359-6446 (ISSN-L)
- OpenAlex
- W2732263607
- Cited by
- 743
- References
- 0
- FWCI
- 22.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Bonandi, E., Christodoulou, M. S., Fumagalli, G., Perdicchia, D., Rastelli, G., & Passarella, D. (2017). The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. Drug Discovery Today. https://doi.org/10.1016/j.drudis.2017.05.014
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