Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: A pilot study
Abstract
The efficacy of stimulant treatment in patients with substance use disorders and comorbid attention deficit hyperactivity disorder (ADHD) has been tested for cocaine and alcohol dependence but so far no studies have been conducted in amphetamine dependent individuals. The present trial was a pilot study aiming to test the feasibility of treating amphetamine dependent patients with comorbid ADHD with central stimulant medication. The study was a double-blind, placebo controlled trial with parallel groups design comparing the efficacy of a fixed dose (72mg) of OROS methylphenidate (MPH) with placebo (PL) in reducing ADHD symptoms in currently abstinent adults with amphetamine dependence and ADHD. Twenty-four treatment seeking patients who met the DSM IV criteria for amphetamine dependence and ADHD were randomized to MPH/PL. The trial was conducted at an outpatient facility with twice weekly visits, measuring ADHD symptoms and drug use. Patients rated their ADHD symptoms on a weekly basis and provided supervised urine specimens for drug toxicology twice weekly. All patients participated in weekly sessions of a skills training programme. Both the groups significantly reduced their self-rated ADHD symptoms during the 12-week treatment but there was no difference between the two treatment arms. Drug use, both measured by urine toxicology and self-report did not differ between the groups. No difference was found between the two groups with regards to craving for amphetamine or in re…
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Multiple studies have provided evidence that psychostimulant treatment in individuals with substance use disorders and ADHD is not associated with a significant worsening of substance abuse.
“However, multiple studies have provided evidence that psychostimulant treatment in individuals with substance use disorders and ADHD is not associated with a significant worsening of substance abuse (249, 250).”
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References 23 · Cited by 83
- Authors
- Konstenius, M., Jayaram-Lindström, N., Beck, O., & Franck, J.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Konstenius, Maija
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 108
- Issue
- 1-2
- Pages
- 130-133
- ISSN
- 0376-8716 (ISSN-L)
- OpenAlex
- W1968445289
- Cited by
- 83
- References
- 23
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 8
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- methylphenidate, sustained drug release, amphetamine dependence, attention deficit hyperactivity disorder, comorbidities, stimulant medication, ADHD symptom reduction, drug craving, treatment retention, skills training, substance use disorders
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Chronic Disease, Delayed-Action Preparations, Double-Blind Method, Drug Tolerance, Female, Humans, Male, Methylphenidate, Pilot Projects, Psychiatric Status Rating Scales, Amphetamine-Related Disorders
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