The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Touchpoints—opportunities to predict and prevent opioid overdose: a cohort study.
Open accessAbstract
Background Medical care, public health, and criminal justice systems encounters could serve as touchpoints to identify and intervene with individuals at high-risk of opioid overdose death. The relative risk of opioid overdose death and proportion of deaths that could be averted at such touchpoints are unknown.Methods We used 8 individually linked data sets from Massachusetts government agencies to perform a retrospective cohort study of Massachusetts residents ages 11 and older. For each month in 2014, we identified past 12-month exposure to 4 opioid prescription touchpoints (high dosage, benzodiazepine co-prescribing, multiple prescribers, or multiple pharmacies) and 4 critical encounter touchpoints (opioid detoxification, nonfatal opioid overdose, injection-related infection, and release from incarceration). The outcome was opioid overdose death. We calculated Standardized Mortality Ratios (SMRs) and Population Attributable Fractions (PAFs) associated with touchpoint exposure.Results The cohort consisted of 6,717,390 person-years of follow-up with 1315 opioid overdose deaths. We identified past 12-month exposure to any touchpoint in 2.7% of person-months and for 51.8% of opioid overdose deaths. Opioid overdose SMRs were 12.6 (95% CI: 11.1, 14.1) for opioid prescription and 68.4 (95% CI: 62.4, 74.5) for critical encounter touchpoints. Fatal opioid overdose PAFs were 0.19 (95% CI: 0.17, 0.21) for opioid prescription and 0.37 (95% CI: 0.34, 0.39) for critical encounter touchpoints.Conclusions Using public health data, we found eight candidate touchpoints were associated with increased risk of fatal opioid overdose, and collectively identified more than half of opioid overdose decedents. These touchpoints are potential targets for development of overdose prevention interventions.
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“Hospitalizations are critical opportunities to engage patients who are at high risk for overdose to prevent future overdoses, as hospital addiction care with referral to treatment increases outpatient SUD treatment engagement.19,20”
From Assessment of Annual Cost of Substance Use Disorder in US Hospitals (2021) · cites this paper as [20]
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Cites
CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016
Dowell, D., Haegerich, T. M., & Chou, R. (2016) · JAMA · doi:10.1001/jama.2016.1464 · Cited by 5,161 · cited 9×
“An evaluation of one program demonstrated feasibility in initiating MOUD with successful linkage to post-discharge care, and a pragmatic multi-site trial of inpatient addiction consult services is underway (McNeely et al., 2019; Trowbridge et al., 2017).”
BackgroundInfluentialIncreases in drug and opioid-involved overdose deaths – United States, 2010-2015
Rudd, R. A., Seth, P., David, F., & Scholl, L. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm655051e1 · Cited by 2,194 · cited 1×
“(Rudd et al., 2016) Several overdose risk factors are well-established and can be identified through medical care, public health, or criminal justice systems encounters.”
BackgroundSordo, L., Barrio, G., Bravo, M. J., Indave, B. I., Degenhardt, L., Wiessing, L., Ferri, M., & Pastor-Barriuso, R. (2017) · BMJ · doi:10.1136/bmj.j1550 · Cited by 1,816 · cited 1×
“Naloxone distribution programs and treatment with medications for opioid use disorder (MOUD) are associated with reduced opioid overdose mortality (McDonald and Strang, 2016; Sordo et al., 2017; Walley et al., 2013).”
BackgroundRelease from prison–a high risk of death for former inmates
Binswanger, I. A., Stern, M. F., Deyo, R. A., Heagerty, P. J., Cheadle, A., Elmore, J. G., & Koepsell, T. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmsa064115 · Cited by 1,684
Association Between Opioid Prescribing Patterns and Opioid Overdose-Related Deaths
Bohnert, A. S. B. (2011) · JAMA · doi:10.1001/jama.2011.370 · Cited by 1,509 · cited 1×
“Known opioid prescription touchpoints associated with increased risk of fatal opioid overdose include high opioid dosage, co-prescribing opioids and benzodiazepines, and receiving or filling opioid prescriptions from multiple providers or pharmacies (Baumblatt et al., 2014; Bohnert et al., 2011; Dunn et al., 2010; Gar…”
BackgroundOpioid Prescriptions for Chronic Pain and Overdose
Dunn, K. M., Saunders, K. W., Rutter, C. M., Banta‐Green, C. J., Merrill, J. O., Sullivan, M. D., Weisner, C. M., Silverberg, M. J., Campbell, C. I., Psaty, B. M., et al. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00006 · Cited by 1,265 · cited 1×
“Known opioid prescription touchpoints associated with increased risk of fatal opioid overdose include high opioid dosage, co-prescribing opioids and benzodiazepines, and receiving or filling opioid prescriptions from multiple providers or pharmacies (Baumblatt et al., 2014; Bohnert et al., 2011; Dunn et al., 2010; Gar…”
BackgroundVital signs: changes in opioid prescribing in the United States, 2006-2015.
Guy, G. P., Zhang, K., Bohm, M. K., Losby, J., Lewis, B., Young, R., Murphy, L. B., & Dowell, D. (2017) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6626a4 · Cited by 1,117
Larochelle, M. R., Bernson, D., Land, T., Stopka, T. J., Wang, N., Xuan, Z., Bagley, S. M., Liebschutz, J. M., & Walley, A. Y. (2018) · Annals of Internal Medicine · doi:10.7326/m17-3107 · Cited by 1,076 · cited 3×
“More specifically, studies among overdose survivors and individuals released from incarceration have shown MOUD are associated with reduced opioid overdose death yet a minority receive them (Green et al., 2018; Larochelle et al., 2018).”
BackgroundMethodSelf-citationWalley, A. Y., Xuan, Z., Hackman, H. H., Quinn, E., Doe-Simkins, M., Sorensen-Alawad, A., Ruiz, S., & Ozonoff, A. (2013) · BMJ · doi:10.1136/bmj.f174 · Cited by 999 · cited 1×
“Naloxone distribution programs and treatment with medications for opioid use disorder (MOUD) are associated with reduced opioid overdose mortality (McDonald and Strang, 2016; Sordo et al., 2017; Walley et al., 2013).”
BackgroundEmergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence
D’Onofrio, G., O’Connor, P. G., Pantalon, M. V., Chawarski, M. C., Busch, S. H., Owens, P. H., Bernstein, S. L., & Fiellin, D. A. (2015) · JAMA · doi:10.1001/jama.2015.3474 · Cited by 913
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Keyes, K. M., Rutherford, C. G., Hamilton, A. D., Barocas, J. A., Gelberg, K. H., Mueller, P. P., Feaster, D. J., El‐Bassel, N., & Cerdá, M. (2022) · Drug and Alcohol Dependence Reports · doi:10.1016/j.dadr.2022.100052 · Cited by 235
Assessment of Annual Cost of Substance Use Disorder in US Hospitals
Peterson, C., Li, M., Xu, L., Mikosz, C. A., & Luo, F. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.0242 · Cited by 200
Racial Inequality in Receipt of Medications for Opioid Use Disorder
Barnett, M. L., Meara, E. R., Lewinson, T., Hardy, B., Chyn, D., Onsando, W. M., Huskamp, H. A., Mehrotra, A., & Morden, N. E. (2023) · New England Journal of Medicine · doi:10.1056/nejmsa2212412 · Cited by 190
Kilaru, A. S., Xiong, R. A., Lowenstein, M., Meisel, Z. F., Perrone, J., Khatri, U. G., Mitra, N., & Delgado, M. K. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.5852 · Cited by 138
Winhusen, T. M., Walley, A. Y., Fanucchi, L. C., Hunt, T., Lyons, M., Lofwall, M. R., Brown, J. L., Freeman, P. R., Nunes, E. V., Beers, D., et al. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108325 · Cited by 135
“, cirrhosis, chronic kidney disease, COPD, asthma, sleep apnea, congestive heart failure; infections related to drug use) (Bosilkovska et al., 2012; Green et al., 2012; Jolley et al., 2015; Larochelle et al., 2019; Vu et al., 2018); and/or 6) injecting drugs (Bazazi et al.”
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Metadata
- Authors
- Larochelle, M. R., Bernstein, R., Bernson, D., Land, T., Stopka, T. J., Rose, A. J., Bharel, M., Liebschutz, J. M., & Walley, A. Y.
- Affiliations
- Boston University (US)
- Massachusetts Department of Public Health (US)
- University of Massachusetts Chan Medical School (US)
- Tufts University (US)
- RAND Corporation (US)
- University of Pittsburgh (US)
- Corresponding author
- Larochelle, Marc R.
- ORCID
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 204
- Pages
- 107537
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC7020606
- OpenAlex
- W2971555090
- Cited by
- 189
- References
- 52
- Citations by year
- 2026: 20 · 2025: 21 · 2024: 36 · 2023: 25 · 2022: 23 · 2021: 47 · 2020: 16 · 2019: 1
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- School of Medicine, Boston University
- National Institute on Drug Abuse
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Epidemiology › HIV, Drug Use, Sexual Risk
- Keywords
- opioid overdose, overdose prevention, touchpoints, opioid prescribing, multiple prescribers, opioid detoxification, injection-related infections, incarceration, drug overdose deaths, population attributable fraction, standardized mortality ratio
- MeSH terms
- Adolescent, Adult, Analgesics, Opioid, Child, Criminal Law, Female, Forecasting, Humans, Male, Massachusetts, Middle Aged, Opioid-Related Disorders, Patient Acceptance of Health Care, Drug Prescriptions, Retrospective Studies, Risk, Young Adult, Drug Overdose
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