Advanced glycation end products (AGEs) and their soluble receptors (sRAGE) as early predictors of reno-vascular complications in patients with uncontrolled type 2 diabetes mellitus
Abstract
Aim To evaluate the role of advanced glycation end-products (AGEs) and their soluble receptors (sRAGE) expression levels as predictors of vascular complications in uncontrolled type 2 diabetes mellitus (T2DM). Methods Cross-sectional study was conducted on T2DM adults of both sexes who attended the outpatient service of Al-Karak Teaching Hospital, Jordan during the period from June 2017 to August 2018. Participants were categorized in two groups according to their glycemic control and the presence of reno-vascular complications. Twenty healthy subjects were recruited as control group. Blood sample was obtained from all participants and used for the assessment of FBG, HbA1c, serum AGEs and sRAGE, serum urea and creatinine; 24 h urine was also collected for the determination of urinary albumin. Results Diabetic subjects with vascular complication had a significantly higher serum AGEs 50.3 ± 13 vs. 28.9 ± 8 pg/ml) and AGEs/sRAGE ratio (0.058 ± 0.02 vs. 0.037 ± 0.02) associated with significantly lower serum sRAGE (868.7 ± 50.8 vs. 912.8 ± 294.3) compared to those with no complications. Serum AGEs and sRAGE showed weak negative and non-significant association in both groups of patients. However, the AGEs/sRAGE ration was inversely and significantly associated with the urinary albumin/creatinine ratio (r = - 0.51, P = 0.009) only in DM patients with reno-vascular complications. Conclusion We found an association between AGEs/sRAGE ratio and urinary albumin/serum creatinine ratio i…
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Farhan et al. found elevated AGE levels comparing T2D patients with and without vascular diseases using a competitive ELISA Kit without specification of detected glycoxidation products.
“In contrast, Farhan et al. found elevated AGE levels comparing the latter groups by using a competitive ELISA Kit without specification of detected glycoxidation products [159,160].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [159]
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References 31 · Cited by 26
- Authors
- Farhan, S. S., & Hussain, S. A.
- Affiliations
- Alrafidain University College (IQ)
- ORCID
- Farhan, Sinan Subhi
- Venue
- Diabetes & Metabolic Syndrome: Clinical Research & Reviews
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 13
- Issue
- 4
- Pages
- 2457-2461
- ISSN
- 1871-4021 (ISSN-L)
- OpenAlex
- W2954626990
- Cited by
- 26
- References
- 31
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 6
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes & Metabolic Syndrome Clinical Research & Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- advanced glycation end products, soluble receptor for advanced glycation end products, type 2 diabetes, uncontrolled diabetes, diabetic vascular complications, diabetic nephropathy, urinary albumin-creatinine ratio, glycemic control
- MeSH terms
- Receptor for Advanced Glycation End Products, Blood Glucose, Cardiovascular Diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Diabetic Nephropathies, Female, Follow-Up Studies, Glycated Hemoglobin, Humans, Male, Middle Aged, Prognosis, Biomarkers, Case-Control Studies, Glycation End Products, Advanced
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