Ictal visual hallucinations due to frontal lobe epilepsy in a patient with bipolar disorder
Open accessAbstract
In ictal psychosis with complex visual hallucinations (VHs), widespread functional changes of cortical networks have been suggested. We describe the clinical and EEG findings of a patient with bipolar disorder who manifested complex VHs associated with intense emotional symptoms caused by frontal epileptic seizures. This description highlights the challenges of diagnosing the epileptic nature of new psychotic phenomena in patients with previous psychiatric disorders and shines light into the role of the frontal cortex in the genesis of complex VHs.
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Spontaneous epileptic discharges in the PFC have occasionally been noted to induce visual perceptual experiences.
“Despite widespread reports of null effects following iES of the PFC (Penfield and Perot, 1963;Selimbeyoglu and Parvizi, 2010;Fox et al., 2020), spontaneous epileptic discharges in the PFC have occasionally been noted to induce visual perceptual experiences (Bancaud and Talairach, 1992;Chauvel et al., 1995;Manfioli et al., 2013).”
From Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain (2021) · cites this paper as Manfioli et al., 2013
The Case report describes bilateral frontal epileptic activity on EEG during a complex visual hallucination, and the Discussion and conclusion says frontal seizures could underpin such hallucinations. The paper does not localize the discharges specifically to the prefrontal cortex (PFC), as the claim states. (LLM, conf=0.83)
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Research works printed but not linked: 13
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Raccah, O., Block, N., & Fox, K. C. R. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1141-20.2020 · Cited by 96 · see citing works
- Authors
- Manfioli, V., Saladini, M., & Cagnin, A.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Cagnin, Annachiara
- ORCID
- Cagnin, Annachiara
- Venue
- Epilepsy & Behavior Case Reports
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 1
- Pages
- 146-149
- ISSN
- 2213-3232 (ISSN-L)
- PMC
- PMC4150638
- OpenAlex
- W1987090177
- Cited by
- 7
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 2 · 2018: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Epilepsy & Behavior Case Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc-nd)
- Funders
- Department of Neurosciences, University of Padova, Italy
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- frontal lobe epilepsy, bipolar disorder, complex visual hallucinations, frontal cortex, emotional symptoms, EEG findings, cortical networks
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