Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration

Constable, Ian J.; Pierce, Cora M.; Lai, Chooi-May; Magno, Aaron L.; Degli-Esposti, Mariapia A.; French, Martyn A.; McAllister, Ian L.; Butler, Steve; Barone, Samuel B.; Schwartz, Steven D.; Blumenkranz, Mark S.; Rakoczy, Elizabeth P.

doi:10.1016/j.ebiom.2016.11.016

Phase 2a Randomized Clinical Trial: Safety and Post Hoc Analysis of Subretinal rAAV.sFLT-1 for Wet Age-related Macular Degeneration

Background We present the results of a Phase 2a randomized controlled trial investigating the safety, and secondary endpoints of subretinal rAAV.sFLT-1 gene therapy in patients with active wet age-related macular degeneration (wAMD). Methods All patients (n = 32), (ClinicalTrials.gov; NCT01494805…