FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

Cited by (137)

Items 101–137 of 137

  1. The IGF2BP3–FASN axis drives lipid metabolic reprogramming to promote brain colonization in non-small cell lung cancer
    Jingwei Li, Shumin Ouyang, Ziyou Lin, Keren Peng, Jiayu Yan, Minyuan Lu, Wen Bo Ding, Jianshan Mo, Yingxue Su, Libin Wang et al. · 2025 · Cell Death and Disease
  2. Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities
    Chieh-Ting Fang, Hsiao‐Hui Kuo, Oyundari Amartuvshin, Hwei‐Jan Hsu, Sih-Long Liu, Jhong-Syuan Yao, Ling‐Huei Yih · 2023 · Cell Death Discovery
  3. Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin Cancer
    Eunjin Kook, Do‐Hee Kim · 2024 · Metabolites
  4. Metabolic control of cancer progression as novel targets for therapy
    Sarmistha Talukdar, Luni Emdad, Rajan Gogna, Swadesh Kumar Das, Paul B. Fisher · 2021 · Advances in cancer research
  5. Caloric restriction alters lipid metabolism to contribute to tumor growth inhibition
    Evan C. Lien, Anna M. Westermark, Zhaoqi Li, Kiera M. Sapp, Matthew G. Vander Heiden · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Protein palmitoylation: A potential therapeutic target in cardiovascular diseases
    Sijia Zhao, Yanyan Yang, Hong Li, Pin Sun, Xiangqin He, Chao Wang, Jingjing Zhang, Yu Tian, Tao Yu, Zhirong Jiang · 2025 · Acta Pharmaceutica Sinica B
  7. The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancer
    Г. С. Захарова, Andrey A. Poloznikov, Lidiia Astakhova, M. P. Raigorodskaya, Zoya B. Khesina, К. А. Фомичева, А. К. Buryak, B. Yа. Alekseev · 2018 · Russian Chemical Bulletin
  8. The choice of tissue fixative is a key determinant for mass spectrometry imaging based tumor metabolic reprogramming characterization
    Chenglong Sun, Fukai Wang, Xiao Dan Wang, Yanling Geng, Shubin Song, Zhiyong Yu, Wei Liu · 2020 · Analytical and Bioanalytical Chemistry
  9. Metabolic basis of cardiac dysfunction in cancer patients
    Jane C. Figueiredo, Neil A. Bhowmick, Anja Karlstaedt · 2024 · Current Opinion in Cardiology
  10. Carcinoma espinocelular oral
    FERNANDA DOS SANTOS MOREIRA · 2017
  11. Regulation of Lipid Metabolism Under Stress and Its Role in Cancer
    Rimsha Munir, Nousheen Zaidi · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
  12. Targeting Fatty Acid Synthase to Halt Tumor Progression and Enhance Radiosensitivity in Breast Cancer Cells
    Ching-I Chen, Hui‐Wen Chan, Ching‐Yi Shen, Hui‐Yen Chuang · 2024 · Journal of Medical and Biological Engineering
  13. Designing metabolic target-specific inhibitors for cancer therapy
    Tejveer Singh, Arun Sidram Kharat, Brijesh Rathi, Dhruv Kumar · 2022 · Elsevier eBooks
  14. Targeting Metabolic Reprogramming: A New Frontier in Cancer Therapy
    Ravi Kumar Thakur, Niti Kumari · 2025 · Springer eBooks
  15. Exploiting Metabolic Reprogramming and Its Therapeutic Vulnerabilities in Prostate Cancer
    Ukasha Ahmed · 2025 · annals of urologic oncology
  16. From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisions
    Yue Zhu, Chunyu Ma, Liping Zhong, Tingting Wang, Weiwei Liu, Zishu Wang · 2026 · Cell Communication and Signaling
  17. Significance of Lipid Metabolism Reprogramming in Tumor Microenvironment and Development of Novel Therapeutic Intervention
    Pallabi Mondal, Sankar Bhattacharyya · 2026 · Cell Biochemistry and Function
  18. Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance
    Joshua J. Souchek, Lindsey Muraskin, Lucas J. Houser, Quyen Vu, Aaron M. Mohs · 2019
  19. DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCER
    James Drury · 2021 · UKnowledge (University of Kentucky)
  20. Atorvastatin Improves Cisplatin Sensitivity Through Modulation of Cholesteryl Ester Homeostasis in Breast Cancer Cells
    Diandra Zipinotti dos Santos, Isabella dos Santos Guimarães, Mariam F. Hakeem-Sanni, Blake J. Cochran, Kerry‐Anne Rye, Thomas Grewal, Andrew J. Hoy, Letícia Batista Azevedo Rangel · 2022 · Research Square
  21. The role of fatty acids metabolism on cancer progression and therapeutics development
    Catarina Moreira-Barbosa, Andreia Matos, Rui Fernandes, Miguel Mendes-Ferreira, Rafaela C. Rodrigues, Tânia Cruz, Ângela M. Costa, Ana Patrícia Cardoso, Carmen Ghilardi, María José Oliveira et al. · 2022 · Elsevier eBooks
  22. Atorvastatin Improves Cisplatin Sensitivity Through Modulation of Cholesteryl Ester Homeostasis in Breast Cancer Cells
    Diandra Zipinotti dos Santos, Isabella dos Santos Guimarães, Mariam F. Hakeem-Sanni, Blake J. Cochran, Kerry‐Anne Rye, Thomas Grewal, Andrew J. Hoy, Letícia Batista Azevedo Rangel · 2022 · Research Square
  23. Metabolite-Based Biosignature of Pancreatic Cancer
    Anjali Aggarwal, Vinit Sharma, Justin Jacob, Ankita Semwal, Daisy Sahni · 2024 · Springer eBooks
  24. S‐acylation of Ca2+ transport proteins in cancer
    Sana Kouba, Nicolas Demaurex · 2024 · Chronic Diseases and Translational Medicine
  25. Fatty Acid Synthase (Fasn) Inhibition Cooperates with Bh3 Mimetic Drugs to Overcome Resistance to Mitochondrial Apoptosis in Pancreatic Cancer
    Javier Abel Menéndez, Travis Vander Steen, Ingrid C. Espinoza, Cristina Duran, Guillem Casadevall, Eila Serrano‐Hervás, Elisabet Cuyàs, Sara Verdura, George W. Kemble, Scott H. Kaufmann et al. · 2024 · SSRN Electronic Journal
  26. ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer
    Ana García García, María Ferrer Aporta, Germán Vallejo-Palma, Antonio Giráldez Trujillo, Raquel Castillo‐González, David Calzón Lozano, Alberto Mora Perdiguero, Raúl Muñoz Velasco, Miguel Colina Castro, Elena de Simone Benito et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Additional file 1 of Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancer
    Fukai Wang, Ma, Shuangshuang, Chen, Panpan, Yuhao Han, Liu, Zhaoyun, Xinzhao Wang, Sun, Chenglong, Zhiyong Yu · 2023 · Figshare
  28. Additional file 1 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
    Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
  29. Additional file 2 of Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer
    Zhou, Lijie, Kaixuan Du, Dai, Yiheng, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Liu, Yuanhao, Lailai Zhang, Zhu, Ronghui et al. · 2024 · Figshare
  30. Additional file 3 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
    Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
  31. Additional file 1 of Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancer
    Zhou, Lijie, Kaixuan Du, Yiheng Dai, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Liu, Yuanhao, Lailai Zhang, Zhu, Ronghui et al. · 2024 · Figshare
  32. Additional file 2 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy
    Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
  33. Targeting the cell cycle : A novel therapeutic strategy against ATIP3- deficient breast cancer
    Maria M. Haykal · 2023 · theses.fr (ABES)
  34. Rewired lipid metabolism in castration-resistant prostate cancer: molecular interplay between glucose metabolism and sterol synthesis
    Harini Priyadharshini K B, Sumathy Arockiasamy, Sriram Krishnamoorthy · 2026 · Molecular Biology Reports
  35. Histone lactylation-associated gene FASN promotes prostate cancer progression through NF-κB signaling pathway
    Shiyong Xin, Wang Qin, Junjie Su, Ruixin Li, Guanyu Li, Z D Zhang, Chu Wang, Yingao Zhu, Liming Feng, Zhongwei Gao · 2026 · European journal of medical research
  36. Tumoral Metabolism at the Intersection of Oncogene Signaling, Epigenetics and Immunology: Emerging Therapeutic Strategies in Cancer
    Bhoomendra A. Bhongade, Areeg Anwer Ali, Mohamed El‐Tanani, Shakta Mani Satyam, Sirajunisa Talath, Adil Farooq Wali, Syed Arman Rabbani, Walaa Ibraheem, Karolina Hoffmann, Авагимян Ашот Арманович et al. · 2026 · Current Issues in Molecular Biology
  37. Inhibition of Acetyl-CoA Carboxylase Induces Endoplasmic Reticulum Stress and Augments the Efficacy of Anticancer Therapies
    Naing Lin Shan, Henriette U. Balinda, Jiawei Dai, Yueyue Wang, Hao-Kuen Lin, Michał Marczyk, Gerson Espinoza Campos, Sheila Umlauf, Martina S.J. McDermott, Iriana Colorado et al. · 2026 · Clinical Cancer Research