FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression
Heuer, Timothy S., Ventura, Richard, Mordec, Kasia, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George·2017·EBioMedicine
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- Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalitiesChieh-Ting Fang, Hsiao‐Hui Kuo, Oyundari Amartuvshin, Hwei‐Jan Hsu, Sih-Long Liu, Jhong-Syuan Yao, Ling‐Huei Yih · 2023 · Cell Death Discovery
- Elucidating the Role of Lipid-Metabolism-Related Signal Transduction and Inhibitors in Skin CancerEunjin Kook, Do‐Hee Kim · 2024 · Metabolites
- Metabolic control of cancer progression as novel targets for therapySarmistha Talukdar, Luni Emdad, Rajan Gogna, Swadesh Kumar Das, Paul B. Fisher · 2021 · Advances in cancer research
- Caloric restriction alters lipid metabolism to contribute to tumor growth inhibitionEvan C. Lien, Anna M. Westermark, Zhaoqi Li, Kiera M. Sapp, Matthew G. Vander Heiden · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Protein palmitoylation: A potential therapeutic target in cardiovascular diseasesSijia Zhao, Yanyan Yang, Hong Li, Pin Sun, Xiangqin He, Chao Wang, Jingjing Zhang, Yu Tian, Tao Yu, Zhirong Jiang · 2025 · Acta Pharmaceutica Sinica B
- The effect of ELOVL6 fatty acid elongase inhibition on the expression of genes associated with the metastasis of breast cancerГ. С. Захарова, Andrey A. Poloznikov, Lidiia Astakhova, M. P. Raigorodskaya, Zoya B. Khesina, К. А. Фомичева, А. К. Buryak, B. Yа. Alekseev · 2018 · Russian Chemical Bulletin
- The choice of tissue fixative is a key determinant for mass spectrometry imaging based tumor metabolic reprogramming characterizationChenglong Sun, Fukai Wang, Xiao Dan Wang, Yanling Geng, Shubin Song, Zhiyong Yu, Wei Liu · 2020 · Analytical and Bioanalytical Chemistry
- Metabolic basis of cardiac dysfunction in cancer patientsJane C. Figueiredo, Neil A. Bhowmick, Anja Karlstaedt · 2024 · Current Opinion in Cardiology
- Carcinoma espinocelular oralFERNANDA DOS SANTOS MOREIRA · 2017
- Regulation of Lipid Metabolism Under Stress and Its Role in CancerRimsha Munir, Nousheen Zaidi · 2022 · Sub-cellular biochemistry/Subcellular biochemistry
- Targeting Fatty Acid Synthase to Halt Tumor Progression and Enhance Radiosensitivity in Breast Cancer CellsChing-I Chen, Hui‐Wen Chan, Ching‐Yi Shen, Hui‐Yen Chuang · 2024 · Journal of Medical and Biological Engineering
- Designing metabolic target-specific inhibitors for cancer therapyTejveer Singh, Arun Sidram Kharat, Brijesh Rathi, Dhruv Kumar · 2022 · Elsevier eBooks
- Targeting Metabolic Reprogramming: A New Frontier in Cancer TherapyRavi Kumar Thakur, Niti Kumari · 2025 · Springer eBooks
- Exploiting Metabolic Reprogramming and Its Therapeutic Vulnerabilities in Prostate CancerUkasha Ahmed · 2025 · annals of urologic oncology
- From lipid modification to cell death: the diverse roles of S-palmitoylation in cell fate decisionsYue Zhu, Chunyu Ma, Liping Zhong, Tingting Wang, Weiwei Liu, Zishu Wang · 2026 · Cell Communication and Signaling
- Significance of Lipid Metabolism Reprogramming in Tumor Microenvironment and Development of Novel Therapeutic InterventionPallabi Mondal, Sankar Bhattacharyya · 2026 · Cell Biochemistry and Function
- Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistanceJoshua J. Souchek, Lindsey Muraskin, Lucas J. Houser, Quyen Vu, Aaron M. Mohs · 2019
- DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCERJames Drury · 2021 · UKnowledge (University of Kentucky)
- Atorvastatin Improves Cisplatin Sensitivity Through Modulation of Cholesteryl Ester Homeostasis in Breast Cancer CellsDiandra Zipinotti dos Santos, Isabella dos Santos Guimarães, Mariam F. Hakeem-Sanni, Blake J. Cochran, Kerry‐Anne Rye, Thomas Grewal, Andrew J. Hoy, Letícia Batista Azevedo Rangel · 2022 · Research Square
- The role of fatty acids metabolism on cancer progression and therapeutics developmentCatarina Moreira-Barbosa, Andreia Matos, Rui Fernandes, Miguel Mendes-Ferreira, Rafaela C. Rodrigues, Tânia Cruz, Ângela M. Costa, Ana Patrícia Cardoso, Carmen Ghilardi, María José Oliveira et al. · 2022 · Elsevier eBooks
- Atorvastatin Improves Cisplatin Sensitivity Through Modulation of Cholesteryl Ester Homeostasis in Breast Cancer CellsDiandra Zipinotti dos Santos, Isabella dos Santos Guimarães, Mariam F. Hakeem-Sanni, Blake J. Cochran, Kerry‐Anne Rye, Thomas Grewal, Andrew J. Hoy, Letícia Batista Azevedo Rangel · 2022 · Research Square
- Metabolite-Based Biosignature of Pancreatic CancerAnjali Aggarwal, Vinit Sharma, Justin Jacob, Ankita Semwal, Daisy Sahni · 2024 · Springer eBooks
- S‐acylation of Ca2+ transport proteins in cancerSana Kouba, Nicolas Demaurex · 2024 · Chronic Diseases and Translational Medicine
- Fatty Acid Synthase (Fasn) Inhibition Cooperates with Bh3 Mimetic Drugs to Overcome Resistance to Mitochondrial Apoptosis in Pancreatic CancerJavier Abel Menéndez, Travis Vander Steen, Ingrid C. Espinoza, Cristina Duran, Guillem Casadevall, Eila Serrano‐Hervás, Elisabet Cuyàs, Sara Verdura, George W. Kemble, Scott H. Kaufmann et al. · 2024 · SSRN Electronic Journal
- ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic CancerAna García García, María Ferrer Aporta, Germán Vallejo-Palma, Antonio Giráldez Trujillo, Raquel Castillo‐González, David Calzón Lozano, Alberto Mora Perdiguero, Raúl Muñoz Velasco, Miguel Colina Castro, Elena de Simone Benito et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of Imaging the metabolic reprograming of fatty acid synthesis pathway enables new diagnostic and therapeutic opportunity for breast cancerFukai Wang, Ma, Shuangshuang, Chen, Panpan, Yuhao Han, Liu, Zhaoyun, Xinzhao Wang, Sun, Chenglong, Zhiyong Yu · 2023 · Figshare
- Additional file 1 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapyAli Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
- Additional file 2 of Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancerZhou, Lijie, Kaixuan Du, Dai, Yiheng, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Liu, Yuanhao, Lailai Zhang, Zhu, Ronghui et al. · 2024 · Figshare
- Additional file 3 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapyAli Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
- Additional file 1 of Metabolic reprogramming based on RNA sequencing of gemcitabine-resistant cells reveals the FASN gene as a therapeutic for bladder cancerZhou, Lijie, Kaixuan Du, Yiheng Dai, Youmiao Zeng, Yongbo Luo, Mengda Ren, Wenbang Pan, Liu, Yuanhao, Lailai Zhang, Zhu, Ronghui et al. · 2024 · Figshare
- Additional file 2 of Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapyAli Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Rizotto, Lara, Mélanie Planque, Ginevra Doglioni et al. · 2023 · Figshare
- Targeting the cell cycle : A novel therapeutic strategy against ATIP3- deficient breast cancerMaria M. Haykal · 2023 · theses.fr (ABES)
- Rewired lipid metabolism in castration-resistant prostate cancer: molecular interplay between glucose metabolism and sterol synthesisHarini Priyadharshini K B, Sumathy Arockiasamy, Sriram Krishnamoorthy · 2026 · Molecular Biology Reports
- Histone lactylation-associated gene FASN promotes prostate cancer progression through NF-κB signaling pathwayShiyong Xin, Wang Qin, Junjie Su, Ruixin Li, Guanyu Li, Z D Zhang, Chu Wang, Yingao Zhu, Liming Feng, Zhongwei Gao · 2026 · European journal of medical research
- Tumoral Metabolism at the Intersection of Oncogene Signaling, Epigenetics and Immunology: Emerging Therapeutic Strategies in CancerBhoomendra A. Bhongade, Areeg Anwer Ali, Mohamed El‐Tanani, Shakta Mani Satyam, Sirajunisa Talath, Adil Farooq Wali, Syed Arman Rabbani, Walaa Ibraheem, Karolina Hoffmann, Авагимян Ашот Арманович et al. · 2026 · Current Issues in Molecular Biology
- Inhibition of Acetyl-CoA Carboxylase Induces Endoplasmic Reticulum Stress and Augments the Efficacy of Anticancer TherapiesNaing Lin Shan, Henriette U. Balinda, Jiawei Dai, Yueyue Wang, Hao-Kuen Lin, Michał Marczyk, Gerson Espinoza Campos, Sheila Umlauf, Martina S.J. McDermott, Iriana Colorado et al. · 2026 · Clinical Cancer Research