Epigenetic changes in the CRH gene are related to severity of suicide attempt and a general psychiatric risk score in adolescents

The Discussion reports that a CRH CpG site was hypermethylated in adolescents at high psychiatric risk but hypomethylated in adult severe suicide attempters, and cautions against direct comparison of the cohorts. The paper does not report an opposite direction of cortisol regulation between pediatric and adult cohorts; its Introduction discusses cortisol findings without making that comparison. Page numbers are not available in our copy. (LLM, conf=0.87)

Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

The Results section reports reduced CRH promoter methylation in people with more severe suicide attempts, supporting the CRH portion. The copy does not substantiate methylation alterations in SKA2, BDNF, or SLC6A4 as implicated in suicidal behavior; its References section mentions SKA2 expression, not methylation. No page numbers are available in the indexed passages. (LLM, conf=0.88)

The Discussion reports opposite directions at one CRH methylation site: hypermethylation in adolescents at high psychiatric risk and hypomethylation in adults with severe suicide attempts. It cautions that directly comparing the cohorts is difficult. Because the groups differed in psychiatric outcome as well as age, the paper does not establish that age determines the direction of stress-related methylation. (LLM, conf=0.88)

The Results report that CRH promoter site cg19035496 was hypomethylated in the adult high-risk/severe-attempt group, while the Discussion reports hypermethylation at that site in adolescents at high psychiatric risk. However, the Methods define the adult group using a violent attempt, a high severity-scale score, or later completed suicide; the finding is not reported specifically for adults with violent attempts. (LLM, conf=0.87)