The DOI matches its Crossref record; 148 of the 148 references it cites were found in a registry or an index.
Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion
Open accessAbstract
Chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment with enormous potential, demonstrating impressive antitumor activity in the treatment of hematological malignancies. However, CAR T cell exhaustion is a major limitation to their efficacy, particularly in the application of CAR T cells to solid tumors. CAR T cell exhaustion is thought to be due to persistent antigen stimulation, as well as an immunosuppressive tumor microenvironment, and mitigating exhaustion to maintain CAR T cell effector function and persistence and achieve clinical potency remains a central challenge. Here, we review the underlying mechanisms of exhaustion and discuss emerging strategies to prevent or reverse exhaustion through modifications of the CAR receptor or CAR independent pathways. Additionally, we discuss the potential of these strategies for improving clinical outcomes of CAR T cell therapy.
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Citations
Cites
Molecular and cellular insights into T cell exhaustion
Wherry, E. J., & Kurachi, M. (2015) · Nature Reviews Immunology · doi:10.1038/nri3862 · Cited by 4,652
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CAR-T cell therapy: current limitations and potential strategies
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Transforming Growth Factor-β Signaling in Immunity and Cancer
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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
McLane, L. M., Abdel-Hakeem, M. S., & Wherry, E. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055318 · Cited by 1,975
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
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Cited by
Baessler, A., & Vignali, D. A. A. (2024) · Annual Review of Immunology · doi:10.1146/annurev-immunol-090222-110914 · Cited by 420
Borràs, D. M., Verbandt, S., Ausserhofer, M., Sturm, G., Lim, J., Verge, G. A., Vanmeerbeek, I., Laureano, R. S., Govaerts, J., Sprooten, J., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00605-4 · Cited by 67
“Over-representation of EOMES - signaling, which was indeed associated with the long-term immunosurveillance module here, can potentially limit stem-like phenotype and promote dysregulated exhaustion in CD8 + T cells 58,59 .”
The potential role of CMC1 as an immunometabolic checkpoint in T cell immunity
Chen, Y., Gao, J., Ma, M., Wang, K., Liu, F., Yang, F., Zou, X., Cheng, Z., & Wu, D. (2024) · OncoImmunology · doi:10.1080/2162402x.2024.2344905 · Cited by 13
Lim, S.-K., Lin, W.-C., Pan, Y.-C., Huang, S.-W., Yu, Y.-A., Chang, C.-H., Hu, C.-M. J., Mou, C.-Y., & Mou, K. Y. (2026) · eLife · doi:10.7554/elife.107671.3
Lim, S.-K., Lin, W.-C., Pan, Y.-C., Huang, S.-W., Yu, Y.-A., Chang, C.-H., Hu, C.-M. J., Mou, C.-Y., & Mou, K. Y. (2026) · eLife · doi:10.7554/elife.107671
Metadata
- Authors
- Gumber, D., & Wang, L. D.
- Venue
- eBioMedicine
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 77
- Pages
- 103941
- ISSN
- 2352-3964 (ISSN-L)
- OpenAlex
- W4220721336
- Cited by
- 396
- References
- 148
- FWCI
- 28.91
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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