The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Immunopathophysiology of human sepsis
Open accessAbstract
Sepsis is an ill-defined syndrome yet is a leading cause of morbidity and mortality worldwide. The most recent consensus defines sepsis as life-threatening organ dysfunction caused by a dysregulated host response to infection. However, this definition belies the complexity and breadth of immune mechanisms involved in sepsis, which are characterized by simultaneous hyperinflammation and immune suppression. In this review, we describe the immunopathogenesis of sepsis and highlight some recent pathophysiological findings that have expanded our understanding of sepsis. Sepsis endotypes can be used to divide sepsis patients in different groups with distinct immune profiles and outcomes. We also summarize evidence on the role of the gut microbiome in sepsis immunity. The challenge of the coming years will be to translate our increasing knowledge about the molecular mechanisms underlying sepsis into therapies that improve relevant patient outcomes.
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The third international consensus definitions for sepsis and septic shock (Sepsis-3).
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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
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A guide to immunometabolism for immunologists
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Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure
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Research works printed but not linked: 2
- van der Poll, 2019, Chapter 73: sepsis and septic shock
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Cited by
Li, Z., Zhang, F., Sun, M., Liu, J., Zhao, L., Liu, S., Li, S., & Wang, B. (2023) · PeerJ · doi:10.7717/peerj.15122 · Cited by 43
Li, H., Liao, H., Sun, L., Chen, D., Fei, Y., Yao, M., Huang, B., Guo, X., Song, S., & Bao, H. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2307140 · Cited by 6
Progress on the correlation between sepsis and gut microbiota: a narrative review
Yuan, Y., Li, J., & Yang, C. (2026) · Frontiers in microbiology · doi:10.3389/fmicb.2026.1862891 · Cited by 1
Metadata
- Authors
- Wiersinga, W. J., & van der Poll, T.
- Venue
- eBioMedicine
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 86
- Pages
- 104363
- ISSN
- 2352-3964 (ISSN-L)
- OpenAlex
- W4310772912
- Cited by
- 322
- References
- 83
- FWCI
- 31.54
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by/4.0/ (vor)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91716475)
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- Wiersinga, W. J., & van der Poll, T. (2022). Immunopathophysiology of human sepsis. eBioMedicine. https://doi.org/10.1016/j.ebiom.2022.104363
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
