Association of air pollution and genetic risks with incidence of elderly-onset atopic dermatitis: A prospective cohort study
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Background Elderly-onset atopic dermatitis (AD) is a remarkable subtype and has been put on the agenda owing to its difficulty to control. Understanding the influence of genetic and environmental exposures is crucial to preventing elderly-onset AD. Objectives To explore the association between genes and air pollution on incident elderly-onset AD. Material and methods This study was based on UK Biobank that recruited over 500,000 participants. The genetic risks were categorized into low, intermediate, and high groups according to tertiles of polygenic risk scores. Mixed exposure to various air pollutants was assessed using the weighted quantile sum (WQS) and also categorized based on tertiles. Within each genetic risk group, whether air pollutant mixture was associated with incident elderly-onset AD was estimated. Results 337,910 participants were included in the final analysis, and the mean age was 57.1. The median years for follow-up were 12.0, and the incident cases of AD were 2545. The medium and high air pollution mixture was significantly associated with incident AD compared with the low pollution group, with HRs of 1.182 (P = 0.003) and 1.359 (P Conclusion Air pollution and genetics both independently enhance the risk of newly developed AD, and the effect of air pollutants is stronger than the investigated genes.
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Some studies reported women at a higher risk of developing atopic dermatitis on exposure to air pollutants.
“While some studies reported women at a higher risk of developing AD on exposure to air pollutants [32, 49, 59, 60], other studies reported male individuals at higher risk of developing AD with association with PM [20, 61].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [32]
Only eight included studies used other exposures such as air pollution mixture, industrial air pollution, solid fuel pollution, and hydrocarbons.
“Only eight studies have used other exposures, such as AP mixture, industrial AP, solid fuel pollution, and hydrocarbons [32–36].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [32]
In the present review, atopic dermatitis has shown a significant association with different criteria pollutants in both short- and long-term relationships, but the strength of association might vary.
“In the present review, we [37] found that AD has shown a significant association with different criteria pollutants; both in short- [19, 38–42] and long-term relationships [32, 43–46]; however, the strength of the association might vary.”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [32]
The interactive effect between genetic risks and air pollution showed a higher risk of atopic dermatitis and incident psoriasis at higher genetic risk/genetic susceptibility and higher air pollution levels.
“The interactive effect between genetic risks and AP showed a higher risk of AD and incident psoriasis at higher genetic risk/genetic susceptibility and higher AP levels [32, 70].”
From Air Pollution and Skin Diseases: A Systematic Review of Epidemiological Evidence (2026) · cites this paper as [32]
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References 39 · Cited by 28
- Authors
- Gu, X., Jing, D., Xiao, Y., Zhou, G., Yang, S., Liu, H., Chen, X., & Shen, M.
- Affiliations
- Central South University (CN)
- Corresponding author
- Yang, Songchun
- Liu, Hong
- Chen, Xiang
- Shen, Minxue
- Venue
- Ecotoxicology and Environmental Safety
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 253
- Pages
- 114683
- ISSN
- 0147-6513 (ISSN-L)
- OpenAlex
- W4322507173
- Cited by
- 28
- References
- 39
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 10
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Ecotoxicology and Environmental Safety (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Huxiang Youth Talent Support Program (2022RC1014)
- National Natural Science Foundation of China (82204144)
- Ministry of Industry and Information Technology of the People's Republic of China (TC210804V)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- air pollution, genetic susceptibility, polygenic risk score, air pollutant mixtures, disease incidence, sex differences, population attributable fraction, gene-environment interaction
- MeSH terms
- Aged, Air Pollutants, Air Pollution, Dermatitis, Atopic, Environmental Exposure, Female, Humans, Middle Aged, Prospective Studies, Risk Factors, Incidence, Particulate Matter
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