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Cited by 83Mechanisms of cancer metastasisCancer Cells and MetastasisChemokine receptors and signaling

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The KISS1 metastasis suppressor: A good night kiss for disseminated cancer cells

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Beck, Benjamin H., Welch, Danny R.·2010·European Journal of Cancer
DOI 10.1016/j.ejca.2010.02.023PMC PMC3662025
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Abstract

Re-expression of KISS1 in tumor cell lines allows all antecedent steps of metastasis, but prevents colonization of secondary sites. Because tumor cells have already disseminated by the time of cancer diagnosis, KISS1 may represent a new opportunity for therapeutic intervention. Moreover, numerous clinical reports demonstrate that a loss or reduction of KISS1 expression in different human cancers inversely correlates with tumor progression, metastasis, and survival. Taken together, these observations compel the hypothesis that KISS1 could be of tremendous utility in controlling metastasis in a therapeutic context. In this review, we highlight some key findings from preclinical and clinical studies and discuss strategies whereby KISS1 may be exploited clinically to treat metastases.

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Metadata

Authors
Beck, B. H., & Welch, D. R.
Affiliations
University of Alabama (US)
Corresponding author
Welch, Danny R.
ORCID
Venue
European Journal of Cancer
Publisher
Elsevier BV
Published
2010-05
Volume
46
Issue
7
Pages
1283-1289
ISSN
0959-8049 (ISSN-L)
DOI
10.1016/j.ejca.2010.02.023
PMC
PMC3662025
OpenAlex
W1987952385
Cited by
83
References
2
Citations by year
2026: 4 · 2025: 3 · 2023: 7 · 2022: 6 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 8
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Journal of Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Foundation for Cancer Research
  • U.S. Public Health Service
  • National Cancer Institute (CA134981, CA087728, R01CA087728, R01CA062168, R01CA134981, CA062168)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Keywords
KISS1, metastasis suppressor, metastasis, disseminated tumor cells, tumor colonization, metastasis treatment, tumor progression
MeSH terms
Receptors, Kisspeptin-1, Animals, Chromosomes, Human, Pair 6, Humans, Neoplastic Cells, Circulating, Neoplasm Metastasis, Gene Expression Regulation, Neoplastic, Genes, Tumor Suppressor, Tumor Suppressor Proteins, Receptors, G-Protein-Coupled, Mice, Kisspeptins

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