Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

Wistuba-Hamprecht, Kilian; Martens, Alexander; Heubach, Florian; Romano, Emanuela; Geukes Foppen, Marnix; Yuan, Jianda; Postow, Michael; Wong, Phillip; Mallardo, Domenico; Schilling, Bastian; Di Giacomo, Anna Maria; Khammari, Amir; Dreno, Brigitte; Maio, Michele; Schadendorf, Dirk; Ascierto, Paolo A.; Wolchok, Jedd D.; Blank, Christian U.; Garbe, Claus; Pawelec, Graham; Weide, Benjamin

doi:10.1016/j.ejca.2016.12.011

Peripheral CD8 effector-memory type 1 T-cells correlate with outcome in ipilimumab-treated stage IV melanoma patients

The role of the assessment of peripheral T-cell phenotypes in predicting overall survival (OS) after ipilimumab treatment is unclear. Here, we analyzed mononuclear cells in the blood before and at different time points during treatment with ipilimumab in 137 late stage melanoma patients. The prop…