Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort

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1. Beyond 5‐year survival. A report from the Cooperative Osteosarcoma Study Group ( COSS )
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2. Identification of an early survival prognostic gene signature for localized osteosarcoma patients
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3. Extracellular Vesicles from Highly Metastatic Osteosarcoma Cells Induce Pro‐Tumorigenic Macrophage Phenotypes
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4. Machine Learning versus Cox Models for Predicting Overall Survival in Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data
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5. Methotrexate, Doxorubicin, and Cisplatin Versus Methotrexate, Doxorubicin, and Cisplatin + Ifosfamide in Poor Responders to Preoperative Chemotherapy for Newly Diagnosed High-Grade Osteosarcoma (JCOG0905): A Multicenter, Open-Label, Randomized Trial
   Hiroaki Hiraga, Ryunosuke Machida, Akira Kawai, Toshiyuki Kunisada, Tsukasa Yonemoto, Makoto Endo, Yoshihiro Nishida, Akihito Nagano, Keisuke Ae, Shinichirou Yoshida et al. · 2025 · Journal of Clinical Oncology
6. The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma
   Yoshihiro Araki, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa et al. · 2021 · Scientific Reports
7. A Novel Necroptosis-Related lncRNA Signature for Osteosarcoma
   Yixin Zheng, Jie Xu, Jiexiang Lin, Yuan Lin · 2022 · Computational and Mathematical Methods in Medicine · Retracted
8. Machine learning for predicting the survival in osteosarcoma patients: Analysis based on American and Hebei Province cohort
   Yahui Hao, Di Liang, Shuo Zhang, Siqi Wu, Daojuan Li, Yingying Wang, Miaomiao Shi, Yutong He · 2023 · Biomolecules and Biomedicine
9. Survival outcomes and surgical morbidity based on surgical approach to pulmonary metastasectomy in pediatric, adolescent and young adult patients with osteosarcoma
   Christopher Kuo, Jemily Malvar, Yueh‐Yun Chi, Eugene S. Kim, Rachana Shah, Fariba Navid, James E. Stein, Leo Mascarenhas · 2023 · Cancer Medicine
10. Eugenol: In Vitro and In Ovo Assessment to Explore Cytotoxic Effects on Osteosarcoma and Oropharyngeal Cancer Cells
    Robert Cosmin Racea, Ioana Gabriela Macasoi, Ştefania Dinu, Iulia Pînzaru, Iasmina Marcovici, Cristina Adriana Dehelean, Laura Cristina Rusu, Doina Chioran, Mircea Riviș, Roxana Buzatu · 2023 · Plants
11. Outcomes of comprehensive treatment for primary osteosarcoma
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12. PMMA Bone Cement Composite Functions as an Adjuvant Chemotherapeutic Platform for Localized and Multi‐Window Release during Bone Reconstruction
    Erika L. Cyphert, Nithya Kanagasegar, Ningjing Zhang, Greg D. Learn, Horst A. von Recum · 2022 · Macromolecular Bioscience
13. Comparison of Features and Outcomes of Undifferentiated Pleomorphic Sarcoma of Bone and Soft Tissue
    Charles Gusho, Linus Lee, Jonathan Guntin, Alan T. Blank · 2021 · Journal of Surgical Research
14. Descriptive Epidemiology and Survival Rate of Osteosarcoma: The First National Population-Based Study in the Middle East (2008-2014).
    Amin Karimi, Adel Ebrahimpour, Mehrdad Sadighi, Mohammadreza Chehrassan, Farsad Biglari, Meisam Jafari Kafiabadi, Mohammad Esmaeil Akbari, Mehdi Azizmohammad Looha · 2023 · PubMed Central
15. Advances in prognostic models for osteosarcoma risk
    Yi Yao, Dapeng Wang, Zheng Li, Jinmin Zhao, Manli Tan · 2024 · Heliyon
16. Magnetic Resonance Imaging Radiomics Predicts Histological Response to Neoadjuvant Chemotherapy in Localized High-grade Osteosarcoma of the Extremities
    Yun Zhang, Lanlan Zhi, Jiao Li, Murong Wang, Guoquan Chen, Shaohan Yin · 2024 · Academic Radiology
17. The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre‐clinical study
    Kaan Low, Paola Foulkes, Frank A. Hills, Helen C. Roberts, Britta Stordal · 2024 · Cancer Medicine
18. Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma
    Lin Zhang, Haoming Jiang, Hongzhi Ma · 2025 · Frontiers in Immunology
19. Tumor Immune Microenvironment–Associated Prognostic and Mifamurtide-Response Gene Signatures for Localized Osteosarcoma: A Correlative Study of the ISG/OS-2 Trial
    Emanuela Palmerini, Maria Rosaria Sapienza, Stefano Aldo Pileri, Giorgio Frega, Alberto Righi, Antonina Parafioriti, Alessandro Franchi, Claudio Agostinelli, Simona Righi, Cristina Meazza et al. · 2025 · Clinical Cancer Research
20. Modelling time-varying covariates effect on survival via functional data analysis: application to the MRC BO06 trial in osteosarcoma
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21. Treatment of Osteoporosis With Anabolic Agents and the Risk of Primary Bone Cancers: A Study of 44,728 Patients Treated With Teriparatide and Abaloparatide
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22. Current surgical management of children with osteosarcoma and pulmonary metastatic disease: A survey of the American Pediatric Surgical Association
    Timothy B. Lautz, Mark Krailo, Ruxu Han, Todd E. Heaton, Roshni A. Dasgupta, John J. Doski · 2020 · Journal of Pediatric Surgery
23. Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma
    Yoav S. Zvi, Elif Ugur, Brian D. Batko, Jonathan Benjamin Gill, Michael E. Roth, Richard Greg Gorlick, David C. Hall, Janet Tingling, Donald A. Barkauskas, Jinghang Zhang et al. · 2021 · Sarcoma
24. Construction and validation model of necroptosis-related gene signature associates with immunity for osteosarcoma patients
    Hua Long, Pengfei Lei, Yihe Hu · 2022 · Scientific Reports
25. Predicting recurrence in osteosarcoma via a quantitative histological image classifier derived from tumour nuclear morphological features
    Zhan Wang, Haoda Lu, Yan Wu, Shihong Ren, Diarra Mohamed Diaty, Yanbiao Fu, Yi Zou, Lingling Zhang, Zenan Wang, Fangqian Wang et al. · 2023 · CAAI Transactions on Intelligence Technology
26. Prospects and Advances in Adoptive Natural Killer Cell Therapy for Unmet Therapeutic Needs in Pediatric Bone Sarcomas
    Halin Bareke, Adrián Ibáñez-Navarro, Pilar Guerra‐García, Carlos González Pérez, P. Rubio, Diego Plaza López de Sabando, Ana Sastre Urgellés, Eduardo Jose Ortiz-Cruz, Antonio Pérez‐Martínez · 2023 · International Journal of Molecular Sciences
27. A meta-analysis: the clinical value of PD-1 inhibitor or protein tyrosine kinase inhibitors in the treatment of advanced osteosarcoma
    Binhao Shi, Junli Chang, Xingyuan Sun, Xiaoping Ma, Peng Zhao, Chujie Zhou, Yongjun Wang, Yanping Yang · 2023 · Frontiers in Oncology
28. Poverty, race, ethnicity, and survival in pediatric nonmetastatic osteosarcoma: a Children’s Oncology Group report
    Lenka Anne Skaidrite Ilcisin, Ruxu Han, Mark Krailo, David Stephen Shulman, Brent R. Weil, Christopher Bertero Weldon, Puja J. Umaretiya, Rahela Aziz‐Bose, Katie A. Greenzang, Richard Greg Gorlick et al. · 2024 · JNCI Journal of the National Cancer Institute
29. To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis
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30. Transcription factor c-Myb: novel prognostic factor in osteosarcoma
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31. RETRACTED ARTICLE: Long non-coding RNA taurine up regulated 1 promotes osteosarcoma cell proliferation and invasion through upregulating Ezrin expression as a competing endogenous RNA of micro RNA-377-3p
    Qin Yao, Yingchao Li, Yihua Pei, Bozhen Xie · 2022 · Bioengineered · Retracted
32. Establishment, Maintenance, and Performance of the Cooperative Osteosarcoma Study Group (COSS)
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33. EPB41L4A-AS1 and UNC5B-AS1 have diagnostic and prognostic significance in osteosarcoma
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34. Implementing precision oncology for sarcoma patients: the CCCLMUmolecular tumor board experience
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35. Investigating the effect of tannin films prepared by low-energy electron beam deposition on the inhibition of bone tumors
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36. Zebrafish—A Suitable Model for Rapid Translation of Effective Therapies for Pediatric Cancers
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37. IAP Chemotherapy Regimen Is a Viable and Cost-effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival
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38. Prognostic Nomogram for Predicting 5-Year Overall Survival in Chinese Patients Under 30 Years of Age with High-Grade Osteosarcoma Using High-Dimensional Survival Data
    Zhihong Yao, Zunxian Tan, Jifei Yang, Yihao Yang, Cao Wang, Jiaxiang Chen, Yanan Zhu, Tiying Wang, Lei Han, Lin Zhu et al. · 2020 · Scientific Reports
39. Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma
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40. Molecular profiling of osteosarcoma in children and adolescents from different age groups using a next-generation sequencing panel
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41. Sarcomas of the extremities and the pelvis: comparing local recurrence after incisional and after core-needle biopsy
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42. A Systematic Review of the Heterogenous Gene Expression Patterns Associated with Multidrug Chemoresistance in Conventional Osteosarcoma
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43. Management of Apatinib-Related Adverse Events in Patients With Advanced Osteosarcoma From Four Prospective Trials: Chinese Sarcoma Study Group Experience
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44. MiRNA encoded PTEN’s impact on clinical-pathological features and prognosis in osteosarcoma: A systematic review and meta-analysis
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45. The role of neutrophils in osteosarcoma: insights from laboratory to clinic
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46. Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis
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47. A novel therapeutic strategy for osteosarcoma using anti-GD2 ADC and EZH2 inhibitor
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48. GD2-mediated impairment of macrophage phagocytosis drives pulmonary metastasis in osteosarcoma
    Yunfei He, Peng Hui Yang, Peng Ding, Zeng Zhang, Jichuan Wu, Chunjie Wang, Guanghui Hou, Jun Ge, Quan Zhou, Zhuorun Song et al. · 2025 · Theranostics
49. Mesenchymal stroma drives axonogenesis and nerve-induced aggressiveness in osteosarcoma
    Gemma Di Pompo, Thimios A. Mitsiadis, Pierfrancesco Pagella, Alessandro Pasquarelli, Giuliano Bettini, Silvia Sabattini, Alberto Righi, Sofia Avnet, Nicola Baldini · 2025 · Journal of Experimental & Clinical Cancer Research
50. Neoadjuvant Chemotherapy and Expandable Prosthesis Reconstruction to Treat Osteosarcoma around the Knee in Children
    Junqi Huang, Jiajia Cheng, Wenzhi Bi, Meng Xu, Jinpeng Jia, Gang Han, Wei Wang · 2022 · Orthopaedic Surgery
51. A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma
    Bin Yu, Chengkui Geng, Zhongxiong Wu, Zhongzi Zhang, Aili Zhang, Ze Yang, Jiazheng Huang, Ying Xiong, Huiqin Yang, Zhuoyuan Chen · 2024 · Scientific Reports
52. Quality of Life of Patients With Osteosarcoma in the European American Osteosarcoma Study-1 (EURAMOS-1): Development and Implementation of a Questionnaire Substudy
    Gabriele Calaminus, Meriel E. M. Jenney, Lars Hjorth, Katja Baust, Mark L. Bernstein, Stefan Bielack, Patricia De Vos, Pancras C.W. Hogendoorn, Gordana Jovic, Mark Krailo et al. · 2019 · JMIR Research Protocols
53. The perplexing role of immuno-oncology drugs in osteosarcoma
    Alannah Smrke, Yuen Bun Tam, Peter Meade Anderson, Robin L. Jones, Paul H. Huang · 2021 · Journal of bone oncology
54. A Codispersed Nanosystem of Silver-anchored MoS2 Enhances Antibacterial and Antitumor Properties of Selective Laser Sintered Scaffolds
    Leliang Zheng, Yancheng Zhong, Tiantian He, Shuping Peng, Liuyimei Yang · 2022 · International Journal of Bioprinting
55. Therapeutic Efficacy and Radiobiological Effects of Boric-Acid-Mediated BNCT in an Osteosarcoma-Bearing SD Rat Model
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56. Attenuation of Endoplasmic Reticulum Stress Enhances Carvacrol-Induced Apoptosis in Osteosarcoma Cell Lines
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57. Relationship between tumorigenesis, metastasis, immune evasion, and chemoresistance in osteosarcoma therapy
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58. SATB2 is not a reliable diagnostic marker for distinguishing between oral osteosarcoma and fibro-osseous lesions of the jaws
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59. Tumor necrosis drives prognosis in osteosarcoma: No difference in chemotherapy response and survival between chondroblastic and osteoblastic osteosarcoma
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60. The metastatic role of the CXCL10-CXCR3 axis and its therapeutic potential in osteosarcoma
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61. Pharmacologic inhibition of CSF-1R suppresses intrinsic tumor cell growth in osteosarcoma with CSF-1R overexpression
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62. Predictors and Treatment Outcomes of Pediatric Osteosarcoma in Diverse Socioeconomic Backgrounds in Southeast Asia: A Retrospective Multicenter Study
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63. miR-1297 inhibits osteosarcoma cell proliferation and growth by targeting CCND2.
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64. Effect of c o‐medications and potential risk factors of high‐dose methotrexate‐mediated acute hepatotoxicity in patients with osteosarcoma
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65. Prognostic and clinicopathological value of systemic immune-inflammation index in patients with osteosarcoma: a meta-analysis
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66. Targeting the EphA2 pathway: could it be the way for bone sarcomas?
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67. Development of multifunctional PAA-alginate-carboxymethyl cellulose hydrogel-loaded fiber-reinforced biomimetic scaffolds for controlled release of curcumin
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68. Overview of biodegradable materials for bone repair and osteosarcoma treatment: From bulk to scaffolds
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69. LINC01410 in cancer: a comprehensive review of its oncogenic role, regulatory mechanisms, and clinical implications
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70. Prognostic significance of the ratio of surgically resected to radiologically detected lung nodules in patients with metastatic osteosarcoma
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71. Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
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72. Osteoid Tumors of Bone
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73. Complete remission of metastatic osteosarcoma using combined modality therapy: a retrospective analysis of unselected patients in China
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74. RNA-sequencing predicts a role of androgen receptor and aldehyde dehydrogenase 1A1 in osteosarcoma lung metastases
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76. Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions
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79. Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment
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80. Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures
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81. Prognostic factors for overall survival of conventional osteosarcoma of the appendicular skeleton
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83. Metallocompounds as anticancer agents against osteosarcoma
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84. Global research trends and hotspots in metabolomics of osteosarcoma: a decade-spanning bibliometric and visualized analysis
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85. Causal effect of chemotherapy received dose intensity on survival outcome: a retrospective study in osteosarcoma
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86. Bayesian unsupervised clustering identifies clinically relevant osteosarcoma subtypes
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87. Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy
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89. Analysis of Immune–Stromal Score-Based Gene Signature and Molecular Subtypes in Osteosarcoma: Implications for Prognosis and Tumor Immune Microenvironment
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90. In Situ Analysis of mTORC1/C2 and Metabolism-Related Proteins in Pediatric Osteosarcoma
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91. Development of a Risk Score Model for Osteosarcoma Based on DNA Methylation-Driven Differentially Expressed Genes
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93. Osteosarcoma pre-diagnosed as another tumor: a report from the Cooperative Osteosarcoma Study Group (COSS)
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94. Lung and bone metastases patterns in osteosarcoma: Chemotherapy improves overall survival
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95. MFNG is an independent prognostic marker for osteosarcoma
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96. Outcome of surgical treatment of children and adolescents with primary malignant sacral tumours
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97. Metastasis of Osteosarcoma to the Abdomen: A Report of Two Cases and a Review of the Literature
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98. Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo
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99. Risk factors associated with delayed methotrexate clearance and increased toxicity in pediatric patients with osteosarcoma
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100. A Prospective Observational Cohort Study for Newly Diagnosed Osteosarcoma Patients in the UK: ICONIC Study Initial Results
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