Overexpression of transposable elements is associated with immune evasion and poor outcome in colorectal cancer
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Mounting evidence suggests that retrotransposon dysregulation in cancer is associated with active immune responses.
“Mounting evidence suggests that retrotransposon dysregulation in cancer is associated with active immune responses14,102.”
From Multi-omic analysis of hepatocellular carcinoma reveals aberrant cis-regulatory changes and dysregulated retrotransposons with prognostic potential (2025) · cites this paper as [102]
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Cited by
Sorted by citations
Cheng, C. C. Y., Cheung, M. F., Lee, A. Y., Wu, Q., Chow, S. H.-C., Ang, J. Y. J., Riquelme Medina, I., Lo, G., Wu, H., Yang, W., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09154-w · Cited by 3 · see citing works
- Authors
- Zhu, X., Fang, H., Gladysz, K., Barbour, J. A., & Wong, J. W. H.
- Affiliations
- University of Hong Kong (HK)
- Corresponding author
- Wong, Jason W.H.
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 157
- Pages
- 94-107
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W3196957665
- Cited by
- 35
- References
- 7
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 2
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- European Journal of Cancer (publishedVersion)
- medRxiv (acceptedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- University of Hong Kong
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- transposable elements, colorectal cancer, immune evasion, tumor immune microenvironment, immune cell infiltration, PD-L1 expression, interferon signaling, DNA methyltransferase inhibition, microsatellite instability, tumour-associated macrophages, prognostic factors, JAK/STAT signaling
- MeSH terms
- DNA Transposable Elements, Humans, Immunity, Innate, Colorectal Neoplasms, Tumor Escape, DNA Methylation, Cell Line, Tumor, STAT Transcription Factors, B7-H1 Antigen
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