The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Transplantation of Adipose Derived Stromal Cells is Associated with Functional Improvement in a Rat Model of Chronic Myocardial Infarction
Abstract
Aims: To determine the effect of transplantation of undifferentiated and cardiac pre-differentiated adipose stem cells compared with bone marrow mononuclear cells (BM-MNC) in a chronic model of myocardial infarction. Methods: Ninety-five Sprague–Dawley rats underwent left coronary artery ligation and after 1month received by direct intramyocardial injection either adipose derived stem cells (ADSC), cardiomyogenic cells (AD-CMG) or BM-MNC from enhanced-Green Fluorescent Protein (eGFP) mice. The control group was treated with culture medium. Heart function was assessed by echocardiography and 18F-FDG microPET. Cell engraftment, differentiation, angiogenesis and fibrosis in the scar tissue were also evaluated by (immuno)histochemistry and immunofluorescence. Results: One month after cell transplantation, ADSC induced a significant improvement in heart function (LVEF 46.3±9.6% versus 27.7±8% pre-transplant) and tissue viability (64.78±7.2% versus 55.89±6.3% pre-transplant). An increase in the degree of angiogenesis and a decrease in fibrosis were also detected. Although transplantation of AD-CMG or BM-MNC also had a positive, albeit smaller, effect on angiogenesis and fibrosis in the infarcted hearts, this benefit did not translate into a significant improvement in heart function or tissue viability. Conclusion: These results indicate that transplantation of adipose derived cells in chronic infarct provides a superior benefit to cardiac pre-differentiated ADSC and BM-MNC.
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‘Green mice’ as a source of ubiquitous green cells
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Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells
Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., Pell, C. L., Johnstone, B. H., Considine, R. V., & March, K. L. (2004) · Circulation · doi:10.1161/01.cir.0000121425.42966.f1 · Cited by 2,269
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Cardiomyocyte Grafting for Cardiac Repair: Graft Cell Death and Anti-Death Strategies
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Cited by
Aguado, B. A., Mulyasasmita, W., Su, J., Lampe, K. J., & Heilshorn, S. C. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0391 · Cited by 719
Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications
Silvestre, J.-S., Smadja, D. M., & Lévy, B. I. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2013 · Cited by 255
Adipose-derived stromal cells: their identity and uses in clinical trials, an update
Casteilla, L. (2011) · World Journal of Stem Cells · doi:10.4252/wjsc.v3.i4.25 · Cited by 235
Self-citationSong, Y.-S., Joo, H.-W., Park, I.-H., Shen, G.-Y., Lee, Y., Shin, J. H., Kim, H., & Kim, K.-S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179972 · Cited by 53
Metadata
- Authors
- Mazo, M., Planat-Bénard, V., Abizanda, G., Pelacho, B., Léobon, B., Gavira, J. J., Peñuelas, I., Cemborain, A., Pénicaud, L., Laharrague, P., Joffre, C., Boisson, M., Ecay, M., Collantes, M., Barba, J., Casteilla, L., & Prósper, F.
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05-01
- Volume
- 10
- Issue
- 5
- Pages
- 454-462
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2027016517
- Cited by
- 218
- References
- 5
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mazo, M., Planat-Bénard, V., Abizanda, G., Pelacho, B., Léobon, B., Gavira, J. J., Peñuelas, I., Cemborain, A., Pénicaud, L., Laharrague, P., Joffre, C., Boisson, M., Ecay, M., Collantes, M., Barba, J., Casteilla, L., & Prósper, F. (2008). Transplantation of Adipose Derived Stromal Cells is Associated with Functional Improvement in a Rat Model of Chronic Myocardial Infarction. European Journal of Heart Failure. https://doi.org/10.1016/j.ejheart.2008.03.017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
