Cited by 209Cholinesterase and Neurodegenerative DiseasesFlavonoids in Medical ResearchBioactive natural compounds

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Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase

Katalinić, Maja, Rusak, Gordana, Domaćinović Barović, Jelena, Šinko, Goran, Jelić, Dubravko, Antolović, Roberto, Kovarik, Zrinka·2010·European Journal of Medicinal Chemistry

DOI 10.1016/j.ejmech.2009.09.041

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Abstract

Selected flavonoids: galangin, kaempferol, quercetin, myricetin, fisetin, apigenin, luteolin and rutin, reversibly inhibited human butyrylcholinesterase (BChE, EC 3.1.1.8). Inhibition potency of the flavonoids we attributed to their chemical structure, i.e., the number of OH groups and their side on the phenyl ring. The most potent BChE inhibitor among the tested flavonoids was galangin, which showed 12 times higher preference for binding to BChE (7 micromol/L) than to the related enzyme human acetylcholinesterase (AChE, EC 3.1.1.7). Docking study showed that flavonoids bind to the BChE active site by forming multiple hydrogen bonds and pi-pi interactions. The UV-VIS (200-500 nm) absorption spectra of the flavonoid phosphate buffer solution (pH 7.4), with the exception of rutin, revealed time dependant changes indicating precipitation of flavonoids or in the case of myricetin, a change in the chemical structure resulting in a BChE non-inhibiting specie. Selected flavonoids showed no cytotoxic effect on HepG2 and A549 cell lines at concentrations up to 200 micromol/L. Cytotoxicity was observed only for fisetin, apigenin and luteolin in the THP-1 cell line with IC50 of 30, 60 and 70 micromol/L, respectively.

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
Neurobiology of butyrylcholinesterase
Darvesh, S., Hopkins, D. A., & Geula, C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1035 · Cited by 896
A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties
Harwood, M., Danielewska-Nikiel, B., Borzelleca, J. F., Flamm, G., Williams, G. M., & Lines, T. C. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.05.015 · Cited by 890
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
Hollman, P. C. H., van Trijp, J. M. P., Buysman, M. N. C. P., van der Gaag, M. S., Mengelers, M. J. B., de Vries, J. H. M., & Katan, M. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01367-7 · Cited by 782
Flavonoids in Health and Disease
Rice-Evans, C. A., & Packer, L. (2003) · CRC Press eBooks · doi:10.1201/9780367803681 · Cited by 693
Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine
Mesulam, M. M., Guillozet-Bongaarts, A. L., Shaw, P. L., Levey, A. I., Duysen, E. G., & Lockridge, O. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00613-3 · Cited by 662
Flavonoids and the brain: interactions at the blood–brain barrier and their physiological effects on the central nervous system
Youdim, K. A., Shukitt‐Hale, B., & Joseph, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.002 · Cited by 378
THE INHIBITION OF ARGINASE BY AMINO ACIDS
Hunter, A., & Downs, C. E. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51079-6 · Cited by 324

Flagged first, then by citations

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Rusak, 2002, Food Technol. Biotechnol, 40, 267
Čalić, 2005, Croat. Chem. Acta, 78, 367
Gutzeit, 2005, Croat. Chem. Acta, 78, 337
Kovarik, 1999, Period. Biol., 101, 7
Ngamelue, 2007, Acta Crystallogr., 63, 723
Verbanac, 2005, Croat. Chem. Acta, 78, 133

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Emır, A., & Emir, C. (2020) · Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi · doi:10.17714/gumusfenbil.687185 · Cited by 4
Oxidative degradation of polyunsaturated lipid membranes: Structural changes, mechanistic insights and flavonoid protection
Sadžak, A., Eraković, M., Kriechbaum, M., Mravljak, J., Přibyl, J., Maltar‐Strmečki, N., & Šegota, S. (2026) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2026.139894 · Cited by 3
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Miličević, A., & Šinko, G. (2021) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2021.105757 · Cited by 3
Self-citation
Retracted
Influence of leaf extracts from Melia azedarach L. on butyrylcholinesterase activity in rat liver
Marek, C. B. (2012) · Journal of Medicinal Plants Research · doi:10.5897/jmpr12.635 · Cited by 3
Comprehensive chemical profiling, bioactivity evaluation, and computational modelling of various extracts from cleome ornithopodioides L
Nilufar, Llorent-Martínez, E. J., Uba, A. İ., Yıldıztugay, E., Ferrante, C., Çetiz, M. V., Tzortzakis, N., & Zengin, G. (2025) · Natural Product Research · doi:10.1080/14786419.2025.2494637 · Cited by 2
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Zhang, X., Zhong, G., & Wu, H. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00756-z · Cited by 2
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Piechowiak, T., Skóra, B., Grzelak-Błaszczyk, K., & Sójka, M. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.145704 · Cited by 2
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El-Mokaddem, O. K., Elmasry, G. F., Salama, A., Mansour, H. M., Mahmoud, W. R., & Ghany, L. M. A. A. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118949 · Cited by 2
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Temviriyanukul, P., Thangsiri, S., Inthachat, W., On‐Nom, N., Sahasakul, Y., Aursalung, A., Chupeerach, C., & Suttisansanee, U. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102158 · Cited by 2
Metabolite Profiling of Atriplex leucoclada Boiss.: Exploring its In-Vitro and In-Silico Cholinesterase Inhibition Potential by Molecular Modeling and ADMET Analysis
Badawy, S. A., Hassan, A. R., Korkor, A. M., Bakr, M. S. A., & Mohammed, A. E.-S. I. (2025) · Chemistry Africa · doi:10.1007/s42250-025-01304-1 · Cited by 2
Flavonoid glucodiversification with engineered sucrose-active enzymes
Malbert, Y. (2014) · theses.fr (ABES) · doi:10.70675/d8ac0539z7f22z41c8z9986zd1eebb4d8a2a · Cited by 2
Molecular networking–guided identification of rare p-coumaroyl flavonoid glycosides from Ferula tunetana flowers: Bioactivities, DFT calculations, molecular docking, and drug-likeness assessment
Baccari, W., Saidi, I., Ahmed, O., Valls, J., Znati, M., Téguo, P. W., & Jannet, H. B. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.145661 · Cited by 1
The Identification of Bioactive Compounds in the Aerial Parts of Agrimonia pilosa and Their Inhibitory Effects on Beta-Amyloid Production and Aggregation
Lee, C. H., Ko, M. S., Kim, Y.-S., Hwang, K. W., & Park, S. (2024) · Separations · doi:10.3390/separations11080243 · Cited by 1
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Singh, A., Sahu, S. K., & Sah, A. K. (2026) · BioMed Research International · doi:10.1155/bmri/5968529 · Cited by 1
Comprehensive Organ‐Specific Phenolic Characterization of Endemic Hedysarum candidissimum by Liquid Chromatography–Tandem Mass Spectrometry: Antioxidant, Enzyme‐Inhibitory, and Antiproliferative Activities Supported by Chemometric Analysis
Şimşek, S., Varol, T., Altın, S., Yılmaz, M. A., Aydın, A., ELVEREN, M., Alp, C., Köksal, E., & Осма, Э. (2026) · New Zealand Journal of Botany · doi:10.1002/nzb2.70125 · Cited by 1
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Fırat, M. Ç., Akşit, Z., Şimşek, S., Altın, S., Yıldız, İ., & Akşit, H. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.71533 · Cited by 1
RP–UHPLC–ESI–QTOF–MS analyses and evaluation of the antioxidant, antimicrobial, anti-diabetic and anti-Alzheimer activities of Linum tenue Desf
Chebchoub, S., Kabouche, Z., Bellouche, D., & Kabouche, A. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2373958 · Cited by 1
Integrated Valorization of Acorus Macrospadiceus by Comprehensive Evaluation of Hydro-Distilled Essential Oil and Residual Non-Volatile Extracts
Sun, Z., Wang, Z., Qu, F., Su, X., Lin, Y., Yan, H., Long, W., Zhu, G.-F., & Zhao, T. (2024) · Waste and Biomass Valorization · doi:10.1007/s12649-024-02742-7 · Cited by 1
In vitro Antioxidant and Enzyme Inhibitory Properties, Phenolic Contents and UHPLC-ESI/MSMS Analysis of Aerial Parts of Anacyclus valentinus L. from the High Plateaus of Algeria (Brezina Province)
Hamdani, D., Benamar, H., Bennaceur, M., Chouh, A., & Bensouıcı, C. (2025) · Waste and Biomass Valorization · doi:10.1007/s12649-024-02881-x · Cited by 1
Compounds isolated from Harpalyce brasiliana Benth and their pharmacological properties
Marek, C. B., & Itinose, A. M. (2014) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2013.5224
RP-HPLC-DAD-MS n Analysis and Butyrylcholinesterase Inhibitory Activity of Barbacenia blanchetii Extracts
Barbosa, J. S., Almeida, V. M., Marçal, R. M., & Branco, A. (2015) · Natural Product Communications · doi:10.1177/1934578x1501000646 · Cited by 1
Resíduos de romã (Punica granatum) na prevenção da doença de Alzheimer
Morzelle, M. C. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.11.2013.tde-21022013-104731 · Cited by 1
Planta Medica International Open
Radad, R. M. A. U. C. K. B. K. K. (2022) · Planta Medica International Open · doi:10.1055/s-00032099 · Cited by 1
Assessment of In-House Natural Product and Synthetic Compound Libraries Based on In vitro Inhibition of Cholinesterases
Järvinen, P. P. (2011) · Työväentutkimus Vuosikirja
Avaliação fotoquimiopreventiva do extrato de maçã e da rutina em modelos de pele in vitro e in vivo
de Siqueira, S. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2014.tde-17042015-151957
Identification of Novel Compounds with Anti-Mycobacterial Activity Using in Silico Screening and Pharmacophore Modeling Targeting Mycobacterium Thymidine Monophosphate Kinase
小関, 祐. (2015) · Institutional Repositories DataBase (IRDB) · doi:10.18997/00004236
Efeito neuroprotetor da casca de romã (Punica granatum)
Morzelle, M. C. (2016) · doi:10.11606/t.11.2016.tde-30092016-182359
Concise Semi-Synthesis of a Flavone Glycoside from Marine Angiosperm
Yan, S., Wu, L., & Huang, L. (2022) · Heterocycles · doi:10.3987/com-22-14626
3D QSAR based Virtual Screening of Flavonoids as Acetylcholinesterase Inhibitors
Andole, S., Sd, H., Sudhula, S., Vislavath, L., Boyina, H. K., Gangarapu, K., Bakshi, V., & Devarakonda, K. P. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-31982-2_26
Polyphenolic profile and evaluation of the antimicrobial, antibutyrylcholinesterase, antialpha-amylase and larvicidal activities of Linum trigynum L.
Chebchoub, S., Kabouche, Z., Bellouche, D., & Kabouche, A. (2024) · Chemical Papers · doi:10.1007/s11696-024-03642-9
Investigation of the Polyphenolic Profile of Gin Botanicals and Their Potential Bioactivity
Umego, E. C., & Barry‐Ryan, C. (2025) · Journal of the American Society of Brewing Chemists · doi:10.1080/03610470.2024.2436709
Additional file 1 of Evaluation of cholinesterase inhibitory and antioxidant activity of Wedelia chinensis and isolation of apigenin as an active compound
Islam, M. A., Zaman, S., Biswas, K., Al-Amin, M. Y., Hasan, M. K., Alam, A. H. M. K., Tanaka, T., & Sadik, G. (2021) · Figshare · doi:10.6084/m9.figshare.15064371
Analytical Profiling of Phenolic and Flavonoid Constituents in Ononis angustissima Using LC–ESI–MS/MS Coupled with Multivariate Optimization
Derbak, L., Mohammed, A. S., Rabhi, M. L., Bendif, H., Ayad, R., Rebbas, K., Demirtaş, İ., Chaudhary, A. A., Elfalleh, W., & Garzoli, S. (2026) · Food Analytical Methods · doi:10.1007/s12161-026-03089-6
Molecular Structural Features and Tandem Mass Spectral Characteristics of Flavonoids From the Analysis of the LIPID MAPS Database
Perumal, U., & Sabareesh, V. (2026) · Chemistry & Biodiversity · doi:10.1002/cbdv.202503379

Authors: Katalinić, M., Rusak, G., Domaćinović Barović, J., Šinko, G., Jelić, D., Antolović, R., & Kovarik, Z.
Affiliations: Institute for Medical Research and Occupational Health (HR)
University of Zagreb (HR)
GlaxoSmithKline (Croatia) (HR)
University of Rijeka (HR)
Corresponding author: Kovarik, Zrinka
ORCID: Katalinić, Maja
Rusak, Gordana
Šinko, Goran
Antolović, Roberto
Kovarik, Zrinka
Venue: European Journal of Medicinal Chemistry
Publisher: Elsevier BV
Published: 2010-01
Volume: 45
Issue: 1
Pages: 186-192
ISSN: 0223-5234 (ISSN-L)
DOI: 10.1016/j.ejmech.2009.09.041
OpenAlex: W2084585115
Cited by: 206
References: 23
Citations by year: 2026: 14 · 2025: 16 · 2024: 11 · 2023: 16 · 2022: 22 · 2021: 9 · 2020: 16 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 10 · 2015: 10 · 2014: 15 · 2013: 9 · 2012: 10
FWCI: 5.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: flavonoids, butyrylcholinesterase, acetylcholinesterase, enzyme inhibitors, structure-activity relationship, galangin, quercetin, kaempferol, myricetin, fisetin, apigenin, luteolin, rutin, molecular docking, hydrogen bonding, π-π stacking, cytotoxicity, THP-1 cells, HepG2 cells, A549 cells
MeSH terms: Acetylcholinesterase, Butyrylcholinesterase, Cholinesterase Inhibitors, Flavonoids, Humans, Models, Molecular, Protein Conformation, Substrate Specificity, Cell Line, Tumor

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Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase

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