Small molecules as inhibitors of PCSK9: Current status and future challenges

Xu, Shengtao; Luo, Shanshan; Zhu, Zheying; Xu, Jinyi

doi:10.1016/j.ejmech.2018.11.011

Small molecules as inhibitors of PCSK9: Current status and future challenges

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in regulating lipoprotein metabolism by binding to low-density lipoprotein receptors (LDLRs), leading to their degradation. LDL cholesterol (LDL-C) lowering drugs that operate through the inhibition of PCSK9 are being p…