Drug repositioning: Progress and challenges in drug discovery for various diseases

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-Infected pneumonia in Wuhan, China

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La certeza de lo impredecible: Cultura Educación y Sociedad en tiempos de COVID19

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Regulation of the mevalonate pathway

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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

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Neutralizing Antibodies Against Certain Recently Isolated Viruses in the Sera of Human Beings Residing in East Africa

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

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Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

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Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Wu, C., Liu, Y., Yang, Y., Zhang, P., Zhong, W., Wang, Y., Wang, Q., Xu, Y., Li, M., Li, X., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.02.008 · Cited by 2,367

The hypoxia-driven crosstalk between tumor and tumor-associated macrophages: mechanisms and clinical treatment strategies

Bai, R., Li, Y., Jian, L., Yue-hui, Y., Zhao, L., & Wei, M. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01645-2 · Cited by 296

Enhancing Equitable Access to Rare Disease Diagnosis and Treatment around the World: A Review of Evidence, Policies, and Challenges

Adachi, T., El-Hattab, A. W., Jain, R., Nogales Crespo, K. A., Quirland Lazo, C. I., Scarpa, M., Summar, M., & Wattanasirichaigoon, D. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20064732 · Cited by 168

KG-Predict: A knowledge graph computational framework for drug repurposing

Gao, Z., Ding, P., & Xu, R. (2022) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2022.104133 · Cited by 103

Triclosan: A Small Molecule with Controversial Roles

Sinicropi, M. S., Iacopetta, D., Ceramella, J., Catalano, A. A., Mariconda, A., PELLEGRINO, M. A., Saturnino, C., Longo, P., & Aquaro, S. (2022) · Antibiotics · doi:10.3390/antibiotics11060735 · Cited by 96

A comprehensive review of computational cell cycle models in guiding cancer treatment strategies

Ma, C., & Gürkan-Çavusoglu, E. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00397-7 · Cited by 63

Drug Development Strategies for Malaria: With the Hope for New Antimalarial Drug Discovery—An Update

Pandey, S. K., Anand, U., Siddiqui, W. A., & Tripathi, R. (2023) · Advances in Medicine · doi:10.1155/2023/5060665 · Cited by 55

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

Porta, E. O. J., Kalesh, K., & Steel, P. G. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1233253 · Cited by 53

The prediction of molecular toxicity based on BiGRU and GraphSAGE

Liu, J., Lei, X., Zhang, Y., & Pan, Y. F. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2022.106524 · Cited by 50

Quinolines and isoquinolines as HIV-1 inhibitors: Chemical structures, action targets, and biological activities

Hu, S., Chen, J., Cao, J.-X., Zhang, S., Gu, S., & Chen, F.-E. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106549 · Cited by 51

A Review on Revolutionizing Healthcare Technologies with AI and ML Applications in Pharmaceutical Sciences

Kandhare, P., Kurlekar, M., Deshpande, T., & Pawar, A. (2025) · Drugs and Drug Candidates · doi:10.3390/ddc4010009 · Cited by 58

Molecular Mechanisms of the Antitumor Effects of Mesalazine and Its Preventive Potential in Colorectal Cancer

Słoka, J., Madej, M., & Strzałka‐Mrozik, B. (2023) · Molecules · doi:10.3390/molecules28135081 · Cited by 38

Revitalizing Cancer Treatment: Exploring the Role of Drug Repurposing

Malla, R. R., Sathiyapriya, V., Makena, S., Kapoor, S. S., Verma, D., Raju, A. A., Dunna, M., & Muniraj, N. (2024) · Cancers · doi:10.3390/cancers16081463 · Cited by 42

Recent Insights in Multi‐Target Drugs in Pharmacology and Medicinal Chemistry

Cemali, S. H., Poyraz, S., Belveren, S., Taş, S., Tamer, M. A., Döndaş, N. Y., Döndaş, H. A., & Sansano, J. M. (2025) · ChemMedChem · doi:10.1002/cmdc.202500447 · Cited by 43

Antiviral drug discovery and development: challenges and future directions

Du, S., Hu, X., Li, P., Xu, S., Kim, M., Liu, X., & Zhan, P. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02539-7 · Cited by 41

GCNGAT: Drug–disease association prediction based on graph convolution neural network and graph attention network

Yang, R., Fu, Y., Zhang, Q., & Zhang, L. (2024) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2024.102805 · Cited by 34

The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system

Xin, M., Bi, F., Wang, C., Huang, Y., Xu, Y., Liang, S., Cai, T., Xu, X., Dong, L., Li, T., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.04.005 · Cited by 35

Topical retinoid drug Adapalene: A new frontier in cancer treatment

Sofi, S., Jan, N., Mehraj, U., & Mir, M. A. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101694 · Cited by 33

Indole-Based Compounds as Potential Drug Candidates for SARS-CoV-2

Girgis, A. S., Panda, S. S., Kariuki, B. M., Bekheit, M. S., Barghash, R. F., & Aboshouk, D. R. (2023) · Molecules · doi:10.3390/molecules28186603 · Cited by 30

GDilatedDTA: Graph dilation convolution strategy for drug target binding affinity prediction

Zhang, L., Zeng, W., Chen, J., Chen, J., & Li, K. (2024) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2024.106110 · Cited by 31

Therapeutic Potential of Aspirin Repurposing in Colon Cancer

Iftode, C., Iurciuc, S., Marcovici, I., Macasoi, I. G., Coricovac, D. E., Dehelean, C. A., Ursoniu, S., Rusu, A., & Ardelean, S. (2024) · Pharmaceutical Sciences and Drug Design · doi:10.51847/nydxrap7au · Cited by 29

Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials

Ioakeim‐Skoufa, I., Tobajas-Ramos, N., Menditto, E., Aza‐Pascual‐Salcedo, M., Miguel, A. G., Orlando, V., González‐Rubio, F., Fanlo, A., AZA, C. L., Ostasz, E., et al. (2023) · Cancers · doi:10.3390/cancers15112972 · Cited by 31

Recent Developments on Coumarin Hybrids as Antimicrobial Agents

Peter, S., & Sibali, L. L. (2025) · Antibiotics · doi:10.3390/antibiotics14121226 · Cited by 22

Ketoprofen-loaded quatsomes as a smart repurposed antifungal therapy for vaginal infections: formulation, characterization, and microbiological evaluation

Eldeeb, A. E., Aziz, D. E., Hassan, M. M., Saher, O., & Ahmed, S. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1767624 · Cited by 22

Drug Repurposing to Enhance Antitumor Response to PD-1/PD-L1 Immune Checkpoint Inhibitors

Thuru, X., Magnez, R., Bouazzati, H. E., Vergoten, G., Quesnel, B., & Bailly, C. (2022) · Cancers · doi:10.3390/cancers14143368 · Cited by 22

Decreasing the burden of non-alcoholic fatty liver disease: From therapeutic targets to drug discovery opportunities

Amorim, R., Soares, P., Chavarria, D., Benfeito, S., Cagide, F., Teixeira, J., Oliveira, P. J., & Borges, F. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116723 · Cited by 21

Hydralazine and Hydrazine Derivatives: Properties, Applications, and Repositioning Potential

Romão, I. C., Siqueira, S. M. C., Abreu, F. O. M. D. S., & dos Santos, H. S. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401561 · Cited by 20

Cyclodextrin encapsulation enabling the anticancer repositioning of disulfiram: Preparation, analytical and in vitro biological characterization of the inclusion complexes

Benkő, B.-M., Tóth, G., Moldvai, D., Kádár, S., Szabó, E., Szabó, Z., Kraszni, M., Szente, L., Fiser, B., Sebestyén, A. R., et al. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124187 · Cited by 19

Improving the treatment of bacterial infections caused by multidrug-resistant bacteria through drug repositioning

Glajzner, P., Bernat, A., & Jasińska-Stroschein, M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1397602 · Cited by 19

Multi-perspective neural network for dual drug repurposing in Alzheimer’s disease

Zhao, L., Li, Z., Chen, G., Yin, Y., & Chen, C. Y. (2023) · Knowledge-Based Systems · doi:10.1016/j.knosys.2023.111195 · Cited by 17

SGCLDGA: unveiling drug–gene associations through simple graph contrastive learning

Fan, Y., Zhang, C., Hu, X., Huang, Z., Xue, J., & Deng, L. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae231 · Cited by 17

Target identification by structure-based computational approaches: Recent advances and perspectives

Vita, S. D., Chini, M. G., Bifulco, G., & Lauro, G. (2023) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2023.129171 · Cited by 16

Understanding the Clinical Use of Levosimendan and Perspectives on its Future in Oncology

Ribeiro, E., & Vale, N. (2023) · Biomolecules · doi:10.3390/biom13091296 · Cited by 16

Overview of pro-inflammatory and pro-survival components in neuroinflammatory signalling and neurodegeneration

Kardam, S., Ambasta, R. K., & Kumar, P. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102465 · Cited by 17

Antibacterial Activity of Paroxetine Against Staphylococcus Aureus and Possible Mechanisms of Action

Cabral, V. P. D. F., Rodrigues, D. S., Barbosa, A. D., Moreira, L. E. A., Sá, L. G. D. A. V., da Silva, C. R., Neto, J. B., Silva, J., Marinho, E. S., dos Santos, H. S., et al. (2023) · Future Microbiology · doi:10.2217/fmb-2022-0232 · Cited by 15

A spatial hierarchical network learning framework for drug repositioning allowing interpretation from macro to micro scale

Ren, Z.-H., Zeng, X., Lao, Y., Zheng, H., You, Z., Xiang, H., & Zou, Q. (2024) · Communications Biology · doi:10.1038/s42003-024-07107-3 · Cited by 15

Engineering Exosomes for CNS Disorders: Advances, Challenges, and Therapeutic Potential

Lee, E. C., Choi, D., Lee, D.-H., & Oh, J. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073137 · Cited by 17

Sertindole, an Antipsychotic Drug, Curbs the STAT3/BCL-xL Axis to Elicit Human Bladder Cancer Cell Apoptosis In Vitro

Hsu, C., Yang, W.-T., Lin, J., Lu, C., Hu, K.-C., Lan, T., & Chang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411852 · Cited by 13

Multifunctional Citral–Tryptamine Conjugated Silver Nanoparticles (CT@AgNPs): Antibacterial, Cytotoxicity, and Sensor Application

Deviprasad, M. J., Hemanth, B. S., Shivaswamy, M. B., Prasad, H. S. N., Sumathi, S., Aswathy, R., Sangamesha, M. A., Ananda, A. P., Jayanth, H. S., & Lohith, T. N. (2024) · BioNanoScience · doi:10.1007/s12668-024-01583-x · Cited by 14

The molecular basis of the anticancer effect of statins

Buccioli, G., Testa, C., Jacchetti, E., Pinoli, P., Carelli, S., Ceri, S., & Raimondi, M. T. (2024) · Scientific Reports · doi:10.1038/s41598-024-71240-6 · Cited by 13

Antidepressant-induced membrane trafficking regulates blood-brain barrier permeability

Du, W., Chen, H., Gróf, I., Lemaitre, L., Bocsik, A., Perdyan, A., Mieczkowski, J., Deli, M. A., Hortobágyi, T., Wan, Q., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02626-1 · Cited by 14

Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis

Hernández‐Ochoa, B., Martínez‐Rosas, V., Morales-Luna, L., Calderón-Jaimes, E., Rocha-Ramírez, L. M., Ortega-Cuéllar, D., Rufino-González, Y., González‐Valdez, A., Arreguín‐Espinosa, R., Enríquez‐Flores, S., et al. (2022) · Molecules · doi:10.3390/molecules27248902 · Cited by 13

Importance of Computer-aided Drug Design in Modern Pharmaceutical Research

Agarwal, U., Tonk, R. K., & Paliwal, S. (2025) · Current Drug Discovery Technologies · doi:10.2174/0115701638361318241230073123 · Cited by 14

Current approaches and strategies to identify Hedgehog signaling pathway inhibitors for cancer therapy

Feng, Z., Zhu, S., Li, W., Yao, M., Song, H. L., & Wang, R. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114867 · Cited by 12

Decoding Drug Discovery: Exploring A-to-Z In Silico Methods for Beginners

Rasul, H. O., Ghafoor, D. D., Aziz, B. K., Hassan, B. A., Rashid, T. A., & Kıvrak, A. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-05110-2 · Cited by 16

A Computational Framework for Predicting Novel Drug Indications Using Graph Convolutional Network With Contrastive Learning

Luo, Y., Shan, W., Li, P., Luo, L., Ding, P., & Liang, W. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3387937 · Cited by 11

In vitro evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity

Tamma, M. A., Nsairat, H., El‐Tanani, M., & Madi, R. (2024) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2024.2428405 · Cited by 11

Introduction to Drug Repurposing: Exploring New Applications for Existing Drugs

Ahmad, Z., Rauf, A., Naz, S., & Hemeg, H. A. (2024) · Pharmaceutical science. · doi:10.5772/intechopen.113207 · Cited by 13

Repurposing of Drug Aspirin in Colon Cancer: Therapeutic Approach

Neve, V., Kamble, A., & Karwa, P. N. (2024) · Clinical Cancer Investigation Journal · doi:10.51847/brevhxsqb9 · Cited by 10

Strategies of Pharmacological Repositioning for the Treatment of Medically Relevant Mycoses

Gómez-Gaviria, M., Contreras-López, L. M., Aguilera-Domínguez, J. I., & Mora-Montes, H. M. (2024) · Infection and Drug Resistance · doi:10.2147/idr.s466336 · Cited by 12

Drug repurposing in the treatment of chronic inflammatory diseases

Sarup, S., Obukhov, A. G., Raizada, S., Atre, R., & Baig, M. S. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00730-1 · Cited by 10

Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy

Indira, M., Suluvoy, J. K., Thathapudi, J. J., & Srirama, K. (2024) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-024-00556-z · Cited by 9

5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression

Temiz, K., Gül, A., & Göv, E. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08847-z · Cited by 9

Antiprotozoal agents – Integration of drug discovery, medicinal chemistry, and advanced computational approaches: An in-depth review

Kaushik, A., Makarani, N., Bharadava, K., Gehlot, J., Naik, B. V., Singh, A., Govil, S., & Kaushal, R. S. (2025) · The Microbe · doi:10.1016/j.microb.2025.100395 · Cited by 10

Machine Learning Applications for Drug Repurposing

Yingngam, B. (2024) · doi:10.1002/9781394234196.ch9 · Cited by 9

Some Aspects and Convergence of Human and Veterinary Drug Repositioning

Mag, P., Nemes-Terényi, M., Jerzsele, Á., & Mátyus, P. (2024) · Molecules · doi:10.3390/molecules29184475 · Cited by 12

Drug repurposing: a promising drug discovery strategy for the treatment of emerging epidemic infectious disease

Zhang, S., Zhang, R., Zheng, L., Liu, Y., Fan, Q., Liu, Y., Ning, X., Zhang, Y., Chen, Y., & Liu, H. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11247-x · Cited by 8

Global trends in the burden of malaria: Contemporary diagnostic approaches, and treatment strategies

Amoah, B. D., Owusu-Asenso, C. M., Mensah, A., Seyram, A. C., Dzotefe, G. B., Ebobabaara, T. B., Opoku-Gyebi, F., Gordor, B. Y., & Obeng, B. C. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.20.1.2038 · Cited by 9

OPTUNA optimization for predicting chemical respiratory toxicity using ML models

Shehab, E., Nayel, H., & Taha, M. (2025) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-025-00597-1 · Cited by 7

Redefining Breast Cancer Care by Harnessing Computational Drug Repositioning

Jurj, E.-D., Colibăşanu, D., Vasii, S.-O., Suciu, L., Dehelean, C. A., & Udrescu, L. (2025) · Medicina · doi:10.3390/medicina61091640 · Cited by 7

Network‐based identification of key proteins and repositioning of drugs for non‐small cell lung cancer

Adeyemo, O., Ashimiyu-Abdusalam, Z., Adewunmi, M., Ayano, T., Sohaib, M., & Abdel-Salam, R. (2024) · Cancer Reports · doi:10.1002/cnr2.2031 · Cited by 6

Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis

Zhang, Y., Jiang, Z., Chen, L., Lei, T., & Zheng, X. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05359-5 · Cited by 7

Identification of Hub of the Hub-Genes From Different Individual Studies for Early Diagnosis, Prognosis, and Therapies of Breast Cancer

Alam, M. S., Sultana, A., Kibria, M. K., Khanam, A., Wang, G., & Mollah, M. N. H. (2024) · Bioinformatics and Biology Insights · doi:10.1177/11779322241272386 · Cited by 7

Aceclofenac/Citronellol Oil Nanoemulsion Repurposing Study: Formulation, In Vitro Characterization, and In Silico Evaluation of Their Antiproliferative and Pro-Apoptotic Activity against Melanoma Cell Line

Younis, M. K., Khalil, I. A. H., Younis, N. S., Eldeen, R. R. F., Abdelnaby, R. M., Aldeeb, R. A. E., Taha, A. A., & Hassan, D. H. (2023) · Biomedicines · doi:10.3390/biomedicines11092531 · Cited by 6

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies

e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7

Drug repositioning and ovarian cancer, a study based on Mendelian randomisation analysis

Zhu, L., Zhang, H., Zhang, X., Chen, R., & Xia, L. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1376515 · Cited by 6

Wnt/β-catenin pathway as a potential target for Parkinson’s disease: a cohort study of romosozumab using routinely collected health data in Japan

Inokuchi, S., & Shimamoto, K. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1411285 · Cited by 6

Advances in Molecular Docking Techniques for Targeting Protein Misfolding in Neurodegenerative Diseases

Singh, K., Gupta, J. K., Narayan, S., Rani, K., Jain, D., Porwal, P., Sharma, M. C., & Kumar, S. (2025) · Current Pharmaceutical Biotechnology · doi:10.2174/0113892010298545241108062449 · Cited by 6

Incorporating AI, in silico , and CRISPR technologies to uncover the potential of repurposed drugs in cancer therapy

Gamal, H., Shoeib, E. M., Hajjaj, A., Abdullah, H. E. A., Elramy, E., Ellah, D. A. A., El-Sayed, S. M., & Khder, M. F. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00158g · Cited by 6

AI-based mining of biomedical literature: Applications for drug repurposing for the treatment of dementia

Sikirzhytskaya, A., Tyagin, I., Sutton, S. S., Wyatt, M. D., Safro, I., & Shtutman, M. S. (2024) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2025.103218 · Cited by 6

Drug repurposing: From the discovery of a useful pharmacological effect to making the treatment available to the patient

Deplanque, D., Fetro, C., Ferry, A., Lechat, P. P., Beghyn, T. B., Bernard, C., Bernasconi, A., Bienaymé, H., Cougoule, C., del Bano, J., et al. (2022) · Therapies · doi:10.1016/j.therap.2022.11.009 · Cited by 6

In vitro antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids

Oyeneyin, O. E., Moodley, R., Mashaba, C., Garnie, L. F., Omoboyowa, D. A., Rakodi, G. H., Maphoru, M. V., Balogun, M. O., Hoppe, H. C., Egan, T. J., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38434 · Cited by 6

Auranofin as a Novel Anticancer Drug for Anaplastic Thyroid Cancer

An, S.-C., Jun, H. H., Kim, K. M., Kim, I., Choi, S., Yeo, H., Lee, S., & An, H. (2024) · Pharmaceuticals · doi:10.3390/ph17101394 · Cited by 6

On the potential of drug repurposing in dysphagia treatment: New insights from a real-world pharmacovigilance study and a systematic review

Battini, V., Rocca, S., Guarnieri, G., Bombelli, A., Gringeri, M., Mosini, G., Pozzi, M., Nobile, M., Radice, S., Clementi, E., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1057301 · Cited by 7

Computational screening of FDA-approved drugs to identify potential TgDHFR, TgPRS, and TgCDPK1 proteins inhibitors against Toxoplasma gondii

Gharibi, Z., Shahbazi, B., Gouklani, H., Nassira, H., Rezaei, Z., & Ahmadi, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-32388-9 · Cited by 6

Drug-repurposing by virtual and experimental screening of PFKFB3 inhibitors for pancreatic cancer therapy

Cao, X., Jiang, X., Zhong, Z.-X., Li, X., Liu, L., Li, X., Yu, Y., Chen, Y., Qin, N., Ni, T., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176330 · Cited by 6

First Description of Marinoquinoline Derivatives’ Activity against Toxoplasma gondii

Diethelm, L. T. H., Ramos, A. B. D. S. B., de Lorena, G. B., Trajano, B. I., Santo, R. D. D. E., de Menezes, R. P. B., Scotti, M. T., Colombo, F. A., Marques, M. J., Correia, C. R. D., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16020262 · Cited by 5

Exploiting allosteric modulation: a new frontier for precision medicine

Alum, E. U., Udechukwu, C. D., & Obasi, D. C. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10650-9 · Cited by 5

Unraveling the molecular landscape of non-small cell lung cancer: Integrating bioinformatics and statistical approaches to identify biomarkers and drug repurposing

Sultana, A., Alam, M. S., Khanam, A., & Liang, H. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.109744 · Cited by 5

Repurposing Salicylamides to Combat Phytopathogenic Bacteria and Induce Plant Defense Responses

Ma, Y., He, Y., Deng, P., Zhang, S., Ding, Y., Zhang, Z., Zhang, B., An, J., Wang, Y., & Liu, Y. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202300998 · Cited by 5

Biological Activities of Zinc Oxide Nanoparticles Green Synthesized Using the Aqueous Extract of Dracocephalum kotschyi Boiss

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Antibiofilm activity of promethazine against ESBL-producing strains of Escherichia coli in urinary catheters

da Silva, C. R., Cabral, V. P. D. F., Rodrigues, D. S., Ferreira, T. L., Barbosa, A. D., Neto, J. B. D. A., Barbosa, S. A., Moreira, L. E. A., da Costa, É. R. M., de Queiroz, M. V. F., et al. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106769 · Cited by 5

A High-Throughput Screening Platform Identifies FDA-Approved Drugs That Inhibit SREBP Pathway Activation

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Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analysis

Mahmud, S., Ajadee, A., Sarker, A., Ahmmed, R., Noor, T., Pappu, M. A. A., Islam, M. S., & Mollah, M. N. H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319028 · Cited by 5

Insights into dopaminergic agent cabergoline-induced DNA-destabilisation through spectroscopic, thermodynamic and molecular docking/metadynamics simulation studies

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Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile

Zhang, L., Xue, B., Cao, M., Mao, Y., Ma, F., Wang, L., Yang, X., Zhao, X., Qiu, Z., Tang, J., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00692 · Cited by 4

Repurposed Drugs: Current Trends in Drug Discovery

Srikanth, G., Beda, D. P., & Kumar, N. P. (2024) · Pharmaceutical science. · doi:10.5772/intechopen.1006501 · Cited by 4

Potential of Nanoparticle based Antimicrobial Drug Repurposing to Efficiently Target Alzheimer’s: A Concise Update on Evidence-based Research and Challenges Ahead

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Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture

Słoka, J., Strzałka‐Mrozik, B., Kubica, S., Nowak, I., & Kruszniewska‐Rajs, C. (2025) · Biomedicines · doi:10.3390/biomedicines13010219 · Cited by 4

Potential activity of paroxetine alone and associated with oxacillin as an alternative to prevent Staphylococcus aureus biofilm formation in catheters

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Drug repurposing for osteoarthritis disease modification in the early 21 st century

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Unveiling Potential Targeted Therapeutic Opportunities for Co-Overexpressed Targeting Protein for Xklp2 and Aurora-A Kinase in Lung Adenocarcinoma

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Repurposing a human acetyl-CoA carboxylase inhibitor firsocostat to treat fungal candidiasis alone and in combination

Chen, T., Yao, J., Quan, K., Xu, J., Hang, X., Tong, Q., Liu, G., Luo, P., Zeng, L., Feng, G., et al. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01131-23 · Cited by 5

Solid Lipid Nanoparticles Enhancing the Leishmanicidal Activity of Delamanid

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GTDDA: Graph Convolutional Network and Graph Transformer Structure for Drug Repositioning

Tang, J., Zeng, X., Li, P., Chen, W., Liu, C.-M., & Lei, B. (2023) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm58861.2023.10386002 · Cited by 4

Drug repurposing for parasitic protozoan diseases

Vijayasurya, Gupta, S., Shah, S. K., & Pappachan, A. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.05.001 · Cited by 4

Exploring potential biomarkers and lead molecules in gastric cancer by network biology, drug repurposing and virtual screening strategies

Saha, S., Bapat, S., Vijayasarathi, D., & Vyas, R. (2024) · Molecular Diversity · doi:10.1007/s11030-024-10995-6 · Cited by 4

Genetic Predictors of Paxlovid Treatment Response: The Role of IFNAR2, OAS1, OAS3, and ACE2 in COVID-19 Clinical Course

Buchynskyi, M., Kamyshna, I. I., Halabitska, I., Petakh, P., Oksenych, V., & Kamyshnyi, O. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15040156 · Cited by 4

Drug repurposing for bacterial infections

Ilyas, M., Latif, M. S., Gul, A., Babar, M. M., & Rajadas, J. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.03.031 · Cited by 3

Unveiling the potential antibacterial action of acetylcysteine for managing Staphylococcus aureus wound infections: in vitro and in vivo study

Ahmed, R., & Elekhnawy, E. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04333-7 · Cited by 3

The Cathepsin Family in Disease: From Molecular Mechanisms to Therapeutic Applications

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Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak

Low, Z. Y., Farouk, I. A., & Lal, S. K. (2020) · Viruses · doi:10.3390/v12091058 · Cited by 189

Drug Repurposing in the Treatment of COVID-19

Soylu, M., Özbek, E. N., & Yetik-Anacak, G. (2020) · Bezmialem Science · doi:10.14235/bas.galenos.2020.4925 · Cited by 1

Repurposing Drugs: A New Paradigm and Hopes for Life-threatening Diseases

Chawla, R., Rani, V., Kumar, K., & Mishra, M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815123197123010004

1 Contemporary trends in drug repurposing: Identifying new targets for existing drugs

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DRUG REPURPOSING IN THE ERA OF ARTIFICIAL INTELLIGENCE: FROM MOLECULAR INSIGHTS TO CLINICAL TRANSLATION

Satti Naga Santhosh Reddy1, T. S. S. M. (2026) · European Journal Pharmaceutical and Medical Research · doi:10.5281/zenodo.22686872