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Cited by 25Nanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 66 of the 68 references it cites were found in a registry or an index.

Therapeutic efficacy and gastrointestinal biodistribution of polycationic nanoparticles for oral camptothecin delivery in early and late-stage colorectal tumor-bearing animal model

Ünal, Sedat, Can Öztürk, Süleyman, Bilgiç, Elif, Yanık, Hamdullah, Korkusuz, Petek, Aktaş, Yeşim, Benito, Juan M., Esendağlı, Güneş, Bilensoy, Erem·2021·European Journal of Pharmaceutics and Biopharmaceutics
DOI 10.1016/j.ejpb.2021.10.010
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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world and is the second leading cause of cancer related deaths. New cases are increasingly diagnosed every day, but current therapeutic options are still insufficient for an effective treatment. In CRC treatment, there is a significant need for alternative treatment approaches that can both prevent relapse and provide strong antimetastatic effects as the intestines and colon are prone to metastasis to neighboring organs and tissues as well as the liver and the lung. In this study, optimized polycationic cyclodextrin (CD) nanoparticles for oral Camptothecin (CPT) delivery were comprehensively examined for in vivo performance in early and late stage tumor bearing mouse model in terms of antitumoral and antimetastatic efficacy of CPT bound to polycationic CD nanoparticles in comparison to free CPT. In addition, the gastrointestinal localization of a single administration of fluorescent dye loaded polycationic CD nanoparticles in the gastrointestinal tract at the end of 24 h after oral administration was also imaged and evaluated by in vivo imaging system against fluorescent dye intensity. Results showed that survival percentage was significantly improved in CRC-bearing mice compared to oral CPT solution, with significantly reduced colorectal tumor masses and number of liver metastatic foci (p < 0.05). It was also possible to differentiate between the effectiveness of nanoparticles in early or late stages of CRC. In vivo imaging studies have also confirmed that polycationic CD nanoparticles are able to deliver the therapeutic load up to the colon and tend to accumulate especially in tumor foci, indicating an effective local treatment strategy. In addition number of liver metastases were significantly decreased with the CPT-loaded polycationic CD nanoparticle formulation in both early and late stage tumor models. These findings indicated that CPT-loaded polycationic CD nanoparticles could be an efficient oral nanocarrier formulation for anticancer molecules that have limited application because of oral bioavailability and stability problems.

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Crossref · 10.1016/j.ejpb.2021.10.010

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Metadata

Authors
Ünal, S., Can Öztürk, S., Bilgiç, E., Yanık, H., Korkusuz, P., Aktaş, Y., Benito, J. M., Esendağlı, G., & Bilensoy, E.
Affiliations
  • Hacettepe University (TR)
  • Erciyes University (TR)
  • Consejo Superior de Investigaciones Científicas (ES)
Corresponding author
Bilensoy, Erem
ORCID
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
2021-12
Volume
169
Pages
168-177
ISSN
0939-6411 (ISSN-L)
DOI
10.1016/j.ejpb.2021.10.010
OpenAlex
W3209334983
Cited by
25
References
68
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 4
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
colorectal cancer, camptothecin, oral drug delivery, liver metastasis, nanoparticle drug delivery, oral bioavailability, mouse tumor model, in vivo imaging
MeSH terms
Polyelectrolytes, Administration, Oral, Animals, Antineoplastic Agents, Phytogenic, Biological Availability, Camptothecin, Cyclodextrins, Neoplasm Metastasis, Tissue Distribution, Colorectal Neoplasms, Drug Delivery Systems, Treatment Outcome, Models, Animal, Gastrointestinal Tract, Mice, Nanoparticles

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