Modulation of cellular activity and synaptic transmission in the ventral tegmental area
Abstract
The mesolimbic dopamine system, of which the cell bodies are located in the ventral tegmental area, has been implicated in the physiology of reward and the related pathophysiology of drug abuse. This area has been a site of significant interest to study the effects of drugs of abuse and neurotransmitter systems implicated in the rewarding effects of these compounds. One important aspect of synaptic transmission is the ability of synapses to strengthen or weaken their connection as a consequence of synaptic activity. Recently, it has become apparent that this phenomenon is also present in the ventral tegmental area and that this may bear important functional consequences for the ways in which drugs of abuse assert their effect. Here, we will review the effects of neurotransmitter systems and drugs of abuse on cellular activity and synaptic transmission in the ventral tegmental area.
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The majority of afferents onto DA neurons of the VTA-as much as 70% of synaptic inputs-are GABAergic and have a major impact on the activity of DA cells.
“Given that the majority of afferents onto DA neurons of the VTA -as much as 70 % of synaptic inputs -are GABAergic and have a major impact on the activity of DA cells (Henny et al., 2012; Mathon et al., 2003; White, 1996; Yang et al., 2018)”
From Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease (2021) · cites this paper as Mathon et al., 2003
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References 218 · Cited by 41
- Authors
- Mathon, D. S., Kamal, A., Smidt, M. P., & Ramakers, G. M. J.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Ramakers, Geert M.J
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 480
- Issue
- 1-3
- Pages
- 97-115
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2017077890
- Cited by
- 41
- References
- 218
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 9
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- ventral tegmental area, mesolimbic dopamine system, synaptic plasticity, synaptic transmission, drug abuse, reward, neurotransmitter systems, cellular activity
- MeSH terms
- Animals, Humans, Synaptic Transmission, Neuronal Plasticity, Ventral Tegmental Area, Neurotransmitter Agents
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