The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain

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1. Considerations for Cannabis Use to Treat Pain in Sickle Cell Disease
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3. The thalidomide analgesic effect is associated with differential TNF-α receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain
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4. Antinociception mechanisms of action of cannabinoid-based medicine: an overview for anesthesiologists and pain physicians
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5. Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint
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6. Cannabidiol as an Antioxidant
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7. Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
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8. Plasma and joint tissue pharmacokinetics of two doses of oral cannabidiol oil in guinea pigs (Cavia porcellus)
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9. Impact of conformational and solubility properties on psycho-activity of cannabidiol (CBD) and tetrahydrocannabinol (THC)
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10. Cannabidiol and its application in the treatment of oral diseases: therapeutic potentials, routes of administration and prospects
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11. Topical Cannabidiol for Established Chemotherapy-Induced Neuropathy: A Pilot Randomized Placebo-Controlled Trial
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12. Preinjury Use of Marijuana and Outcomes in Trauma Patients
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13. Cannabidiol attenuates hypersensitivity and oxidative stress after traumatic spinal cord injury in rats
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14. Cannabis constituents for chronic neuropathic pain; reconciling the clinical and animal evidence
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15. Assessing the Safety and Therapeutic Efficacy of Cannabidiol Lipid Nanoparticles in Alleviating Metabolic and Memory Impairments and Hippocampal Histopathological Changes in Diabetic Parkinson’s Rats
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16. Overlapping Mechanisms of Stress-Induced Relapse to Opioid Use Disorder and Chronic Pain: Clinical Implications
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17. Molecular signaling of synthetic cannabinoids: Comparison of CB1 receptor and TRPV1 channel activation
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18. Cannabidiol‐rich non‐psychotropic Cannabis sativa L. oils attenuate peripheral neuropathy symptoms by regulation of CB2 ‐mediated microglial neuroinflammation
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19. Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy
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20. Cannabidiol alleviates LPS ‐inhibited odonto/osteogenic differentiation in human dental pulp stem cells in vitro
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21. Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
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22. Comparative evaluation of ethyl acetate and n‐Hexane extracts of Cannabis sativa L. leaves for muscle function restoration after peripheral nerve lesion
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23. SUMOylation Modulates Reactive Oxygen Species (ROS) Levels and Acts as a Protective Mechanism in the Type 2 Model of Diabetic Peripheral Neuropathy
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24. Cannabidiol and it fluorinate analog PECS-101 reduces hyperalgesia and allodynia in trigeminal neuralgia via TRPV1 receptors
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25. Therapeutic Cannabis and Endocannabinoid Signaling System Modulator Use in Otolaryngology Patients
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26. Translating Endocannabinoid Biology into Clinical Practice: Cannabidiol for Stroke Prevention
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27. Does cannabis alleviate tinnitus? A review of the current literature
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28. Advances in the design and discovery of novel small molecule drugs for the treatment of Dravet Syndrome
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29. Cannabidiol induces systemic analgesia through activation of the PI3Kγ/nNOS/NO/KATP signaling pathway in neuropathic mice. A KATP channel S-nitrosylation-dependent mechanism
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30. Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview
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31. Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat
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32. Immunomodulatory Actions of Cannabinoids: Clinical Correlates and Therapeutic Opportunities for Allergic Inflammation
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33. IUPHAR review- Preclinical models of neuropathic pain: Evaluating multifunctional properties of natural cannabinoid receptors ligands
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34. Neferine alleviates P2X3 receptor in rat dorsal root ganglia mediated neuropathic pain
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35. Neuroprotective constituents from the aerial parts of Cannabis sativa L. subsp. sativa
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36. Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers
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37. Is cannabidiol (CBD) effective to ease separation anxiety?
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38. Trends in Prevalence and Outcomes of Cannabis Use Among Chronic Obstructive Pulmonary Disease Hospitalizations: A Nationwide Population-Based Study 2005–2014
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40. Possible Role of Cannabis in the Management of Neuroinflammation in Patients with Post-COVID Condition
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41. The Development of Cannabinoids as Therapeutic Agents in the United States
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42. Chemotherapy-Induced Neuropathic Pain
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43. Enhancing Cannabichromenic Acid Biosynthesis in Saccharomyces cerevisiae
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44. Cannabidiol reduces neuropathic pain and cognitive impairments through activation of spinal PPARγ
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45. The Mechanism of Cannabichromene and Cannabidiol Alone Versus in Combination in the Alleviation of Arthritis-Related Inflammation
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46. Understanding the endocannabinoid system as a modulator of the trigeminal pain response to concussion
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47. The effects of cannabidiol on nitric oxide synthases: a narrative review on therapeutic implications for inflammation and oxidative stress in health and disease
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48. Cannabidiol as a Modulator of the Development of Alcohol Tolerance in Rats
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49. Assessing Dose- and Sex-Dependent Antinociceptive Effects of Cannabidiol and Amitriptyline, Alone and in Combination, and Exploring Mechanism of Action Involving Serotonin 1A Receptors
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50. Effectiveness of the injectable hyaluronic acid-based microparticles loaded with cannabidiol on rat sciatic nerve injury model
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51. Analgesic and Anti-Inflammatory Effects of 1% Topical Cannabidiol Gel in Animal Models
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52. Cannabinoids in Autoimmune and Rheumatic Diseases
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53. Cannabidiol and the central nervous system: translating into clinics
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56. FDA-approved cannabidiol [Epidiolex®] alleviates Gulf War Illness-linked cognitive and mood dysfunction, hyperalgesia, neuroinflammatory signaling, and declined neurogenesis
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59. EVALUATION OF THERAPEUTIC POTENTIAL OF CANNABIDIOLBASED PRODUCTS IN ANIMAL MODELS OF EPILEPTIC SEIZURES, NEUROPATHIC PAIN AND CHRONIC INFLAMMATION
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62. Can cannabidiol (CBD) help with low back pain?
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63. Protocol for a pragmatic trial of Cannabidiol (CBD) to improve chronic pain symptoms among United States Veterans
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64. Effect of genistein on the cerebellar cortex of adult male albino rats with streptozotocin-induced diabetes mellitus
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65. Cannabinoids and Pain: Mechanisms of Action
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66. Treatment of Ovarian Hyperstimulation Syndrome in a Mouse Model by Cannabidiol, an Angiogenesis Pathway Inhibitor
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72. Morphine-induced side effects can be differentially modulated by cannabidiol in male and female rats
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74. Biodegradable cannabidiol: a potential nanotherapeutic for neuropathic pain
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98. RETRACTED: Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test
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99. Possibilities of therapeutic action of cannabinoids in neurodegenerative diseases
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100. Development of Raynaud Phenomenon Following Use of Medical Cannabis
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