Chemopreventive potential of ferulic acid in 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in Sprague-Dawley rats
Abstract
Aim of the present study was to investigate the chemopreventive potential of ferulic acid on 7,12-dimethylbenz[a]anthracene (DMBA) induced mammary carcinogenesis in Sprague-Dawley rats. The chemopreventive potential of ferulic acid was assessed by monitoring the tumor incidence, as well as analyzing the status of biochemical (enzymatic and non-enzymatic antioxidants and phase II detoxification enzymes) and molecular (p53 and bcl-2) markers during DMBA-induced mammary carcinogenesis. Mammary carcinogenesis was induced in Sprague-Dawley rats by providing a single subcutaneous injection of 25 mg of DMBA in 1 ml emulsion of sunflower oil (0.75 ml) and physiological saline (0.25 ml) to each rat. Oral administration of ferulic acid at a dose of 40 mg/kg body weight to rats treated with DMBA significantly prevented the tumor formation in 80% of animals (8/10). Also, oral administration of ferulic acid significantly protected the biochemical and molecular abnormalities in DMBA treated rats. Although the exact mechanism for the chemopreventive potential of ferulic acid in DMBA-induced mammary carcinogenesis is unclear, its antigenotoxic and antioxidant potential as well as modulatory effect on phase II detoxification cascade could play a possible role.
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The reduction of caffeic and ferulic acids may lower their protective effects against carcinogenesis and mammalian tumors.
“This may lower their protective effects against carcinogenesis and even mammalian tumors (Kuenzig et al., 1984;Baskaran et al., 2010).”
From RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize (2012) · cites this paper as Baskaran et al., 2010
This may lower their protective effects against carcinogenesis and mammalian tumor formation.
“This may lower their protective effects against carcinogenesis and mammalian tumor formation [69,70].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [70]
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References 45 · Cited by 91
- Authors
- Baskaran, N., Manoharan, S., Balakrishnan, S., & Pugalendhi, P.
- Affiliations
- Annamalai University (IN)
- Corresponding author
- Manoharan, Shanmugam
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 637
- Issue
- 1-3
- Pages
- 22-29
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W1989933820
- Cited by
- 91
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 1 · 2018: 2 · 2017: 8 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 11 · 2012: 9
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- ferulic acid, chemoprevention, mammary carcinogenesis, 7,12-dimethylbenz(a)anthracene, tumor incidence, antioxidant enzymes, phase II enzymes, p53, Bcl-2, antigenotoxicity, mammary tumors
- MeSH terms
- Administration, Oral, Animals, Coumaric Acids, Female, Immunohistochemistry, 9,10-Dimethyl-1,2-benzanthracene, Mammary Neoplasms, Animal, Anticarcinogenic Agents, Rats, Sprague-Dawley, Rats
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