Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy

Chen, Ping; Xie, Yeqing; Shen, E.; Li, Gary G.; Yu, Yong; Zhang, Cassie B.; Yang, Yingzhen; Zou, Yunzeng; Ge, Junbo; Chen, Ruizhen; Chen, Haozhu

doi:10.1016/j.ejphar.2011.02.040

Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy

Myocardial fibrosis plays an important role in coxsackievirus B3 (CVB3) induced dilated cardiomyopathy. Excessive transforming growth factor (TGF)-β1 contributes to a pathologic excess of tissue fibrosis. We investigated the effect of astragaloside IV on myocardial fibrosis in CVB3-induced dilate…