Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats

Temiz-Resitoglu, Meryem; Kucukkavruk, Sefika Pinar; Guden, Demet Sinem; Cecen, Pelin; Sari, Ayse Nihal; Tunctan, Bahar; Gorur, Aysegul; Tamer-Gumus, Lulufer; Buharalioglu, Cuneyt Kemal; Malik, Kafait U.; Sahan-Firat, Seyhan

doi:10.1016/j.ejphar.2017.02.034

Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats

Mammalian target of rapamycin (mTOR), a serine/threonine kinase plays an important role in various pathophysiological processes including cancer, metabolic diseases, and inflammation. Although mTOR participates in Toll-like receptor 4 signalling in different cell types, the role of this enzyme in…