Morroniside prevents H2O2 or Aβ1–42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation

Chen, Kang; Lu, Yunwei; Liu, Chenyang; Zhang, Limi; Fang, Zhuyuan; Yu, Guran

doi:10.1016/j.ejphar.2018.07.047

Morroniside prevents H2O2 or Aβ1–42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation

Amyloid‐&bgr; peptide (A&bgr;) plays a causal role in the development and progression of Alzheimer's disease (AD). Oxidative stress and activation of mitogen‐activated protein kinase (MAPK) are involved in A&bgr;‐induced neurotoxicity. Morroniside, one active monomer of dry ripe sarcocarp of Corn…