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Cited by 74Air Quality and Health ImpactsHealth, Environment, Cognitive AgingEnvironmental Justice and Health Disparities

Identifying sensitive windows for prenatal particulate air pollution exposure and mitochondrial DNA content in cord blood

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Rosa, Maria José, Just, Allan C., Guerra, Marco Sánchez, Kloog, Itai, Hsu, Hsiao-Hsien Leon, Brennan, Kasey J., García, Adriana Mercado, Coull, Brent +4 more·2017·Environment International
DOI 10.1016/j.envint.2016.11.007PMC PMC5139686
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Abstract

Introduction Changes in mitochondrial DNA (mtDNA) can serve as a marker of cumulative oxidative stress (OS) due to the mitochondria's unique genome and relative lack of repair systems. In utero particulate matter ≤2.5μm (PM 2.5) exposure can enhance oxidative stress. Our objective was to identify sensitive windows to predict mtDNA damage experienced in the prenatal period due to PM 2.5 exposure using mtDNA content measured in cord blood. Material and methods Women affiliated with the Mexican social security system were recruited during pregnancy in the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) study. Mothers with cord blood collected at delivery and complete covariate data were included (n=456). Mothers' prenatal daily exposure to PM 2.5 was estimated using a satellite-based spatio-temporally resolved prediction model and place of residence during pregnancy. DNA was extracted from umbilical cord leukocytes. Quantitative real-time polymerase chain reaction (qPCR) was used to determine mtDNA content. A distributive lag regression model (DLM) incorporating weekly averages of daily PM 2.5 predictions was constructed to plot the association between exposure and OS over the length of pregnancy. Results In models that included child's sex, mother's age at delivery, prenatal environmental tobacco smoke exposure, birth year, maternal education, and assay batch, we found significant associations between higher PM 2.5 exposure during late pregnancy (35-40weeks) and lower mtDNA content in cord blood. Conclusions Increased PM 2.5 during a specific prenatal window in the third trimester was associated with decreased mtDNA content suggesting heightened sensitivity to PM-induced OS during this life stage.

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  • mtDNA content from umbilical cord leukocytes was inversely correlated with PM2.5 exposure during pregnancy.

    “Rosa et al. [159] observed mtDNA content from umbilical cord leukocytes was inversely correlated with PM2.5 exposure during pregnancy.”

    From Air pollution and children’s health—a review of adverse effects associated with prenatal exposure from fine to ultrafine particulate matter (2021) · cites this paper as [159]

    The Methods say mtDNA was measured in umbilical cord leukocytes, and the Results report lower cord-blood mtDNA content with higher PM2.5 exposure. The significant association was limited to late pregnancy (35–40 weeks’ gestation), a timing qualifier the citing sentence omits. (LLM, conf=0.84)

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Authors
Rosa, M. J., Just, A. C., Guerra, M. S., Kloog, I., Hsu, H.-H. L., Brennan, K. J., García, A. M., Coull, B., Wright, R. J., Téllez Rojo, M. M., Baccarelli, A. A., & Wright, R. O.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Ben-Gurion University of the Negev (IL)
  • Columbia University (US)
  • Instituto Nacional de Salud Pública (MX)
  • Harvard University (US)
ORCID
Venue
Environment International
Publisher
Elsevier BV
Published
2017-01
Volume
98
Pages
198-203
ISSN
0160-4120 (ISSN-L)
DOI
10.1016/j.envint.2016.11.007
PMC
PMC5139686
OpenAlex
W2553689564
Cited by
74
References
3
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 9
FWCI
5.24
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environment International (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministry of Health
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
Keywords
PM2.5, mitochondrial DNA content, oxidative stress, third trimester, umbilical cord blood, air pollution, PROGRESS study
MeSH terms
Adult, Air Pollution, DNA, Mitochondrial, Female, Fetal Blood, Humans, Hypersensitivity, Male, Mexico, Mothers, Pregnancy, Biomarkers, Oxidative Stress, Maternal Exposure, Particulate Matter, Young Adult, Real-Time Polymerase Chain Reaction

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