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Progress report on new antiepileptic drugs: A summary of the Eleventh Eilat Conference (EILAT XI)
Open accessAbstract
The Eleventh Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT XI, took place in Eilat, Israel from the 6th to 10th of May 2012. About 100 basic scientists, clinical pharmacologists and neurologists from 20 countries attended the conference, whose main themes included "Indications overlapping with epilepsy" and "Securing the successful development of an investigational antiepileptic drug in the current environment". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 1994. Like the EILAT X report, the current manuscript focuses only on the preclinical and clinical pharmacology of AEDs that are currently in development. These include brivaracetam, 2-deoxy-glucose, ganaxolone, ICA-105665, imepitoin, NAX 801-2, perampanel and other AMPA receptor antagonists, tonabersat, valnoctamide and its homologue sec-propylbutylacetamide (SPD), VX-765 and YK3089. Since the previous Eilat conference, retigabine (ezogabine) has been marketed and four newer AEDs in development (NAX 810-2, SPD, tonabersat and VX-765) are included in this manuscript.
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“Although, there is an abundance of diverse antiepileptic drugs, most of them exert their actions by inhibition of the voltage-gated sodium or calcium channels or by potentiation of the GABA-mediated synaptic transmission [11], which results in a symptomatic approach in most cases; the goal of these drugs is to eliminate or at least reduce the number and/or severity of seizures.”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [11]
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The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
Lynch, B. A., Lambeng, N., Nocka, K., Kensel-Hammes, P., Bajjalieh, S. M., Matagne, A., & Fuks, B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308208101 · Cited by 1,610
The neurobiology of antiepileptic drugs
Rogawski, M. A., & Löscher, W. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1430 · Cited by 1,243
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
Hosie, A. M., Wilkins, M. E., da Silva, H. M. A., & Smart, T. G. (2006) · Nature · doi:10.1038/nature05324 · Cited by 752
Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy
Barton, M. E., Klein, B. D., Wolf, H. H., & White, H. S. (2001) · Epilepsy Research · doi:10.1016/s0920-1211(01)00302-3 · Cited by 614
Self-citationMehta, A. K., & Ticku, M. K. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00052-6 · Cited by 613
The role of cytokines in the pathophysiology of epilepsy
Vezzani, A., Balosso, S., & Ravizza, T. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.03.009 · Cited by 564
Key factors in the discovery and development of new antiepileptic drugs
Bialer, M., & White, H. S. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2997 · Cited by 544
Self-citation(2004) · Wiley eBooks · doi:10.1002/9780470752463 · Cited by 509
Adjunctive perampanel for refractory partial-onset seizures
French, J. A., Krauss, G. L., Biton, V., Squillacote, D., Yang, H., Laurenza, A., Kumar, D., Rogawski, M. A., Campanille, V., Floridia, J., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e3182635735 · Cited by 478
Progress report on new antiepileptic drugs: A summary of the Eigth Eilat Conference (EILAT VIII)
Bialer, M., Johannessen, S. I., Kupferberg, H. J., Levy, R. H., Perucca, E., & Tomson, T. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2006.10.008 · Cited by 477
Self-citation
Research works printed but not linked: 13
- Biton, 2009, Brivaracetam as adjunctive treatment of refractory partial-onset seizures in adults: results from two randomized, double-blind, placebo-controlled trials, Epilepsia, 50, 106
- Brodsky, 2007, Safety and tolerability of brivaracetam (ucb 34714) as adjunctive treatment in adults with refractory partial-onset seizures, Epilepsia, 48, 342
- Kwan, 2009, Safety and tolerability of brivaracetam as adjunctive treatment in adults with refractory epilepsy: randomized, double-blind, placebo-controlled trial, Epilepsia, 50, 107
- Niespodziany, 2009, Brivaracetam modulates Na+ currents expressed in a neuroblastoma cell line compared with carbamazepine, Epilepsia, 50, 107
- Rostock, 1998, AWD 131-138 is a potential novel anxiolytic without sedation and amnesia: a comparison with diazepam and buspirone, Naunyn-Schmied. Arch. Pharmacol., 358, R68
- Sargentini-Maier, 2008, Pharmacokinetics, safety and tolerability of brivaracetam in healthy elderly subjects, Epilepsia, 49, 452
- Stafstrom, 2007, 2-Deoxyglucose effects on spatial learning and exploratory behavior in rodents, Epilepsia, 48, 299
- Stockis, 2009, Interaction study between brivaracetam and a combination oral contraceptive, Epilepsia, 50, 96
- Sutula, 2008, Dose-response and time course of action of disease-modifying effects of 2DG on kindling progression: effectiveness of administration after seizures, Epilepsia, 49, 382
- Tober, 1998, AWD 131-138: a derivative of a series of imidazolinones with anticonvulsant activity, Naunyn-Schmied. Arch. Pharmacol., 358, R68
- Tober, 1999, Anticonvulsant activity of AWD 131-138 in genetic animal models of epilepsy, Naunyn-Schmied. Arch. Pharmacol., 359, R97
- Van Paesschen, 2007, Efficacy and tolerability of 50 and 150mg/day brivaracetam (UCB 34714) as adjunctive treatment in adults with refractory partial onset epilepsy, Epilepsia, 48, 329
- Wasterlain, 2009, Short-term and long-term effects of brivaracetam in an animal model of status epilepticus, Epilepsia, 50, 13
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Löscher, W., Potschka, H., Sisodiya, S. M., & Vezzani, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019539 · Cited by 967
Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy
Vezzani, A., Balosso, S., & Ravizza, T. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0217-x · Cited by 928
New avenues for anti-epileptic drug discovery and development
Löscher, W., Klitgaard, H., Twyman, R. E., & Schmidt, D. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4126 · Cited by 696
Krauss, G. L., Klein, P., Brandt, C., Lee, S. K., Milanov, I. G., Milovanović, M., Steinhoff, B. J., & Kamin, M. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30399-0 · Cited by 347
Pathogenesis of acute stroke and the role of inflammasomes
Fann, D. Y., Lee, S.-Y., Manzanero, S., Chunduri, P., Sobey, C. G., & Arumugam, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.004 · Cited by 334
Metadata
- Authors
- Bialer, M., Johannessen, S. I., Levy, R. H., Perucca, E., Tomson, T., & White, H. S.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Oslo University Hospital (NO)
- University of Washington (US)
- University of Pavia (IT)
- Karolinska Institutet (SE)
- University of Utah (US)
- Corresponding author
- Bialer, Meir
- Venue
- Epilepsy Research
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 103
- Issue
- 1
- Pages
- 2-30
- ISSN
- 0920-1211 (ISSN-L)
- OpenAlex
- W2203865877
- Cited by
- 243
- References
- 98
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 14 · 2023: 13 · 2022: 20 · 2021: 17 · 2020: 32 · 2019: 12 · 2018: 10 · 2017: 19 · 2016: 17 · 2015: 23 · 2014: 24 · 2013: 20
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Epilepsy Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institutes of Health
- UCB Pharma
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- antiepileptic drugs, drug development, preclinical pharmacology, clinical pharmacology, brivaracetam, 2-deoxyglucose, ganaxolone, perampanel, AMPA receptor antagonists, tonabersat, retigabine, ezogabine, VX-765, epilepsy
- MeSH terms
- Animals, Anticonvulsants, Clinical Trials as Topic, Congresses as Topic, Epilepsy, Humans, Israel, Drugs, Investigational, Research Report
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