Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR.

Tang, Chongyang; Gu, Yunhe; Wang, Haiyang; Wu, Hongmei; Wang, Yu; Meng, Yao; Han, Zhibin; Gu, Yifei; Ma, Wei; Jiang, Zhenfeng; Song, Yuanyuan; Na, Meng; Lu, Dunyue; Lin, Zhiguo

doi:10.1016/j.eplepsyres.2018.05.001

Targeting of microRNA-21-5p protects against seizure damage in a kainic acid-induced status epilepticus model via PTEN-mTOR.

OBJECTIVE Studies have shown that microRNAs play a role in the development of epilepsy by regulating downstream target messenger (m)RNA. The present study aims to determine the changes associated with microRNA-21-5p (miR-21-5p) during epileptogenesis in a kainic acid rat model, and to assess whet…