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Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review

Cao, Yi, Li, Juan, Liu, Fang, Li, Xiyue, Jiang, Qin, Cheng, Shanshan, Gu, Yuxiu·2016·Environmental Toxicology and Pharmacology
DOI 10.1016/j.etap.2016.07.023
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Abstract

Nanoparticles (NPs) are increasingly used in food, and the toxicity of NPs following oral exposure should be carefully assessed to ensure the safety. Indeed, a number of studies have shown that oral exposure to NPs, especially solid NPs, may induce toxicological responses both in vivo and in vitro. However, most of the toxicological studies only used NPs for oral exposure, and the potential interaction between NPs and food components in real life was ignored. In this review, we summarized the relevant studies and suggested that the interaction between NPs and food components may exist by that 1) NPs directly affect nutrients absorption through disruption of microvilli or alteration in expression of nutrient transporter genes; 2) food components directly affect NP absorption through physico-chemical modification; 3) the presence of food components affect oxidative stress induced by NPs. All of these interactions may eventually enhance or reduce the toxicological responses induced by NPs following oral exposure. Studies only using NPs for oral exposure may therefore lead to misinterpretation and underestimation/overestimation of toxicity of NPs, and it is necessary to assess the synergistic effects of NPs in a complex system when considering the safety of NPs used in food.

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Metadata

Authors
Cao, Y., Li, J., Liu, F., Li, X., Jiang, Q., Cheng, S., & Gu, Y.
Venue
Environmental Toxicology and Pharmacology
Publisher
Elsevier BV
Published
2016-09
Volume
46
Pages
206-210
ISSN
1382-6689
DOI
10.1016/j.etap.2016.07.023
Cited by
104
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
The Scientific Research Fund of Hunan Provincial Education Department (15C1331, 15XZX19, 15QDZ47)

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Cao, Y., Li, J., Liu, F., Li, X., Jiang, Q., Cheng, S., & Gu, Y. (2016). Consideration of interaction between nanoparticles and food components for the safety assessment of nanoparticles following oral exposure: A review. Environmental Toxicology and Pharmacology. https://doi.org/10.1016/j.etap.2016.07.023