Psychiatric profile, quality of life and risk of syncopal recurrence in patients with tilt-induced vasovagal syncope
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AIM: The aim of this study was to investigate the prevalence of psychiatric disorders and quality of life (QoL) in patients with tilt-induced vasovagal syncope and no other comorbidities, and their relationship with the syncopal burden and the risk of recurrence. METHODS: We studied 61 patients with recurrent syncope and positive tilt testing. Controls consisted of 61 sex- and age-matched healthy subjects. Psychiatric diagnoses were formulated on the basis of a structured interview and the Minnesota Multiphase Personality Inventory-2 questionnaire. QoL was assessed by means of the Short-Form Health Survey questionnaire. Patients were followed up for at least 1 year. RESULTS: The presence of psychiatric disorders was higher among patients than controls (71% vs. 23%, P < 0.001), with a prevalence of anxiety (28% vs. 5%), mood (18% vs. 3%), and somatization disorders (29% vs. 3%). The scores of all the QoL scales were statistically lower in patients than controls. An inverse correlation was found between QoL scale scores and syncopal burden. The presence of psychiatric disorders was predictive of syncopal recurrence during follow-up. CONCLUSION: Psychiatric disorders are common in patients with tilt-induced vasovagal syncope, and seem to predict the risk of recurrence. QoL is impaired in these patients, and is inversely correlated with the syncopal burden.
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There is consistent evidence that syncope is associated with worse function on multiple domains of quality of life, such as perceptions of low overall physical health; perception of mental health, including increased fear, somatization, depression, and anxiety; and impairment in activities of daily living, such as driving, working, and attending school.
“There is consistent evidence that syncope is associated with worse function on multiple domains of QoL, such as perceptions of low overall physical health (725,730,734); perception of mental health, including increased fear, somatization, depression, and anxiety (725,727,728,731,734); and impairment in activities of daily living, such as driving, working, and attending school.”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [727]
The QoL evaluation (p. 4) reports lower physical and psychosocial scores in patients than controls, and the results summary (p. 1) reports more anxiety, mood, and somatization disorders. The study concerns recurrent tilt-induced vasovagal syncope, not syncope generally, and our copy does not report increased fear. The driving, working, and school examples are not attached to this source's citation in the citing sentence. (LLM, conf=0.85)
Experimental — accuracy not yet measuredQuality of life is reduced with recurrent syncope.
“QoL is reduced with recurrent syncope (725–733), as demonstrated in studies that compared patients with and without syncope (727,731).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (2017) · cites this paper as [727]
Quality of life is reduced with recurrent syncope, as demonstrated in studies that compared patients with and without syncope.
“QoL is reduced with recurrent syncope (397–405), as demonstrated in studies that compared patients with and without syncope (399,405).”
From 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: Executive Summary (2017) · cites this paper as [399]
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Cites
Impairment of physical and psychosocial function in recurrent syncope
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2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Heart Rhythm · doi:10.1016/j.hrthm.2017.03.004 · Cited by 484 · see citing works
2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.003 · Cited by 327 · see citing works
Shen, W.-K., Sheldon, R. S., Benditt, D. G., Cohen, M. I., Forman, D. E., Goldberger, Z. D., Grubb, B. P., Hamdan, M. H., Krahn, A. D., Link, M. S., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.03.002 · Cited by 155 · see citing works
The genesis and presentation of anxiety in disorders of autonomic overexcitation
Owens, A. P., Low, D. A., Iodice, V., Critchley, H. D., & Mathias, C. J. (2017) · Autonomic Neuroscience · doi:10.1016/j.autneu.2016.10.004 · Cited by 41 · see citing works
Childhood trauma and lifetime syncope burden among older adults
O'Hare, C., McCrory, C., O'Leary, N., O'Brien, H., & Kenny, R. A. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2017.03.019 · Cited by 18 · see citing works
- Authors
- GIADA, F., SILVESTRI, I., ROSSILLO, A., NICOTERA, P., MANZILLO, G., & RAVIELE, A.
- Affiliations
- Ospedale Valduce (IT)
- Corresponding author
- GIADA, F
- Venue
- Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-09
- Volume
- 7
- Issue
- 5
- Pages
- 465-471
- ISSN
- 1099-5129 (ISSN-L)
- OpenAlex
- W2139164794
- Cited by
- 92
- References
- 2
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 12 · 2016: 4 · 2015: 2 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- vasovagal syncope, tilt table test, mental illness, quality of life, anxiety, mood disorders, somatization, Short Form Health Survey
- MeSH terms
- Adult, Mental Disorders, Data Interpretation, Statistical, Female, Humans, Male, Middle Aged, Personality Inventory, Quality of Life, Surveys and Questionnaires, Recurrence, Prevalence, Case-Control Studies, Tilt-Table Test, Syncope, Vasovagal
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