Cited by 370Elasticity and Material ModelingCardiac electrophysiology and arrhythmiasAdvanced Numerical Methods in Computational Mathematics

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The Living Heart Project: A robust and integrative simulator for human heart function

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Baillargeon, Brian, Rebelo, Nuno, Fox, David D., Taylor, Robert L., Kuhl, Ellen·2014·European Journal of Mechanics - A/Solids

DOI 10.1016/j.euromechsol.2014.04.001PMC PMC4175454

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Abstract

The heart is not only our most vital, but also our most complex organ: Precisely controlled by the interplay of electrical and mechanical fields, it consists of four chambers and four valves, which act in concert to regulate its filling, ejection, and overall pump function. While numerous computational models exist to study either the electrical or the mechanical response of its individual chambers, the integrative electro-mechanical response of the whole heart remains poorly understood. Here we present a proof-of-concept simulator for a four-chamber human heart model created from computer topography and magnetic resonance images. We illustrate the governing equations of excitation-contraction coupling and discretize them using a single, unified finite element environment. To illustrate the basic features of our model, we visualize the electrical potential and the mechanical deformation across the human heart throughout its cardiac cycle. To compare our simulation against common metrics of cardiac function, we extract the pressure-volume relationship and show that it agrees well with clinical observations. Our prototype model allows us to explore and understand the key features, physics, and technologies to create an integrative, predictive model of the living human heart. Ultimately, our simulator will open opportunities to probe landscapes of clinical parameters, and guide device design and treatment planning in cardiac diseases such as stenosis, regurgitation, or prolapse of the aortic, pulmonary, tricuspid, or mitral valve.

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Authors: Baillargeon, B., Rebelo, N., Fox, D. D., Taylor, R. L., & Kuhl, E.
Affiliations: Dassault Systèmes (United States) (US)
ORCID: Kuhl, Ellen
Venue: European Journal of Mechanics - A/Solids
Publisher: Elsevier BV
Published: 2014-11
Volume: 48
Pages: 38-47
ISSN: 0997-7538 (ISSN-L)
DOI: 10.1016/j.euromechsol.2014.04.001
PMC: PMC4175454
OpenAlex: W2131414969
Cited by: 370
References: 53
Citations by year: 2026: 33 · 2025: 38 · 2024: 40 · 2023: 37 · 2022: 43 · 2021: 38 · 2020: 29 · 2019: 27 · 2018: 34 · 2017: 18 · 2016: 12 · 2015: 17 · 2014: 4
FWCI: 8.82
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor)
Locations: European Journal of Mechanics - A/Solids (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (U54 GM072970)
National Science Foundation (CMMI 0952021, 1233054)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Physical Sciences › Engineering › Computational Mechanics › Advanced Numerical Methods in Computational Mathematics
Keywords: electromechanical coupling, excitation-contraction coupling, cardiac simulation, cardiac cycle, pressure-volume relationship, heart valves, magnetic resonance imaging, finite element model, heart disease, valve stenosis, valvular regurgitation, mitral valve prolapse

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The Living Heart Project: A robust and integrative simulator for human heart function

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