Anxiolytic-like action of the antidepressant agomelatine (S 20098) after a social defeat requires the integrity of the SCN
Open accessAbstract
In rats, social defeat by an aggressive opponent induces a state of anxiety, shown by a decrease in time spent on active explorative behaviour, an increase in immobility, a clear decrease in frequency of all active behavioural parameters (enhanced passivity). We tested the hypothesis whether acute or sub-chronic agomelatine would antagonize the negative consequences of a social defeat. As many chronobiological actions of melatonin and its receptor agonist agomelatine require the integrity of the suprachiasmatic nuclei (SCN), we examined whether the anxiolytic-like action of agomelatine 1 day after a social defeat is still present in SCN-lesioned rats. Sub-chronic administration of agomelatine caused a clear reduction of the social defeat induced behavioural consequences. A single agomelatine injection prior to the post-defeat test was less effective and a single melatonin injection was hardly effective. SCN lesion did not affect the anxiety reaction after a social defeat. Thus, sub-chronic agomelatine treatment or a single agomelatine injection reduced a state of anxiety and passivity caused by asocial defeat. The defeat-induced behavioural changes do not depend on the SCN but agomelatine showed its anxiolytic action only in sham-lesioned animals, which indicates that the anxiolytic-like action of agomelatine requires the integrity of the SCN. Mechanisms sustaining this activity are discussed.
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Agomelatine was not effective in reducing depression and anxiety-like behavior following social defeat in SCN lesioned animals.
“was not effective in the SCN lesioned animals (Tuma et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Tuma et al., 2005
SCN lesions had no effect on the depression and anxiety-like behaviors displayed after repeated bouts of social defeat.
“a study by Tuma et al found that SCN lesions had no effect on the depression and anxiety-like behaviors that are displayed after repeated bouts of social defeat (Tuma et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Tuma et al., 2005
Agomelatine is normally effective in reducing depression and anxiety-like behavior following social defeat.
“the antidepressant, agomelatine, which is normally effective in reducing the depression and anxiety-like behavior following social defeat”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Tuma et al., 2005
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References 55 · Cited by 60
Research works printed but not linked: 2
- Bohus, B., Benus, R.F., Fokkema, D.S., Koolhaas, J.M., Nyakas, C., Van Oortmersen, G.A., Prins, A.J.A., De Ruiter, A.J.H., Scheurink, A.J.W., Steffens, A.B., 1987. Neuroendocrine states and behavioral an physiological stress responses. In: De Kloet, E.R., Wiegant, V.M., De Wied, D. (Eds.), Progress in Brain Research: Neuropeptides and Brain Function. Elsevier, Amsterdam, pp. 57-70.
- Dubocovich, M.L., North, P.C., Oakley, N.R., Hagan, R.M., 1993. A potent naphtalenic melatonin receptor agonist. In: Touitou, Y., Arendt, J., Pevet, P. (Eds.), Melatonin and the Pineal Gland. From Basic to Clinical Application. Excerpta Medica, Amsterdam, p. 123.
- Authors
- Tuma, J., Strubbe, J. H., Mocaër, E., & Koolhaas, J. M.
- Affiliations
- University of Groningen (NL)
- Institut de Recherches Internationales Servier (France) (FR)
- Corresponding author
- Koolhaas, Jaap M.
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 15
- Issue
- 5
- Pages
- 545-555
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2155344099
- Cited by
- 60
- References
- 55
- Citations by year
- 2023: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 6 · 2012: 2
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- research.rug.nl
- Licence
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- agomelatine, social defeat, anxiety, suprachiasmatic nucleus, SCN lesions, melatonin, antidepressants, anxiolytic-like effects
- MeSH terms
- Acetamides, Animals, Antidepressive Agents, Behavior, Animal, Hypnotics and Sedatives, Male, Motor Activity, Naphthalenes, Social Behavior, Suprachiasmatic Nucleus, Rats, Wistar, Rats
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