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Cited by 23Schizophrenia research and treatmentPsychiatric care and mental health servicesMental Health and Psychiatry

Strategies of Treatment With Olanzapine in Schizophrenic Patients During Stable Phase: Results of a Pilot Study

Rouillon, Frédéric, Chartier, Florence, Gasquet, Isabelle·2008·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2008.04.012
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Abstract

Objective There is an ongoing debate regarding doses of antipsychotic in stable schizophrenia patients. This French pilot study was undertaken to estimate two strategies of treatment with olanzapine in stable phase - maintenance of the acute dose or dose reduction. Method 6 months open, randomized trial comparing two strategies of treatment with olanzapine in 97 schizophrenia stabilized outpatients. Results Mean daily doses at 6 months in the olanzapine full dose (OFD) and reduction dose (ORD) groups were respectively 18.1 mg and 13.3 mg. 4 patients (8%) relapsed in the ORD group versus 3 (6%) in the OFD group. A secondary analysis reflecting more real life setting showed a numerically higher rate of relapse in the dose reduction group (20% versus 10%). Conclusion These results suggest that maintenance treatment with olanzapine, beyond 4 months, with the same dose that was effective acutely could be useful to prevent new psychiatric hospitalization.

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Crossref · 10.1016/j.euroneuro.2008.04.012

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Authors
Rouillon, F., Chartier, F., & Gasquet, I.
Affiliations
  • Université Paris Descartes (FR)
  • Inserm (FR)
Corresponding author
Chartier, Florence
ORCID
Chartier, Florence
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2008-09
Volume
18
Issue
9
Pages
646-652
ISSN
0924-977X (ISSN-L)
DOI
10.1016/j.euroneuro.2008.04.012
OpenAlex
W2064089743
Cited by
23
References
2
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2019: 1 · 2018: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
olanzapine, schizophrenia, long-term antipsychotic treatment, dose reduction, relapse prevention, psychiatric hospitalization, stable phase, antipsychotic dosing
MeSH terms
Olanzapine, Adult, Benzodiazepines, Dose-Response Relationship, Drug, Drug Evaluation, Emergency Services, Psychiatric, Female, Follow-Up Studies, France, Humans, Male, Middle Aged, Pilot Projects, Retrospective Studies, Schizophrenia, Antipsychotic Agents, Secondary Prevention

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