The DOI matches its Crossref record.
SU62THE ROLE OF ENVIRONMENTAL STRESS AND DNA METHYLATION IN THE LONGITUDINAL COURSE OF BIPOLAR DISORDER
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Three EWAS studies in BD, Borderline PD and MDD have consistently shown changes in DNAm in genes from the POU family that are associated with childhood adversity (POU6F2, POU5F1 and POU3F1 respectively), which are genes involved in myelinisation and neurogenesis.
“For instance, three EWAS studies in BD (Comes et al., 2019), Borderline PD (Arranz et al., 2021) and MDD (Lutz et al., 2017) have consistently shown changes in DNAm in genes from the POU family that are associated with CA (POU6F2, POU5F1 and POU3F1 respectively), which are genes involved in myelinisation and neurogenesis (Online Supplementary Table S1 (SM) – EWAS section).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Comes et al., 2019
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Can epigenetics shine a light on the biological pathways underlying major mental disorders?
Alameda, L., Trotta, G., Quigley, H., Rodriguez, V., Gadelrab, R., Dwir, D., Dempster, E., Wong, C. C. Y., & Forti, M. D. (2022) · Psychological Medicine · doi:10.1017/s0033291721005559 · Cited by 60
“For instance, three EWAS studies in BD (Comes et al., 2019), Borderline PD (Arranz et al., 2021) and MDD (Lutz et al., 2017) have consistently shown changes in DNAm in genes from the POU family that are associated with CA (POU6F2, POU5F1 and POU3F1 respectively), which are genes involved in…”
Background
Metadata
- Authors
- Comes, A., Adorjan, K., Andlauer, T., Budde, M., Degenhardt, F., Forstner, A. J., Gade, K., Heilbronner, U., Kalman, J., Kondofersky, I., Papiol, S., Senner, F., Sivalingam, S., Falkai, P., & Schulze, T.
- Affiliations
- Institut für Psychiatrische Phänomik und Genomik (DE)
- Max Planck Institute of Psychiatry (DE)
- University of Bonn (DE)
- Universitätsmedizin Göttingen (DE)
- Helmholtz Munich (DE)
- LMU Klinikum (DE)
- ORCID
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2019
- Volume
- 29
- Pages
- S1300-S1301
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W4229787509
- Cited by
- 1
- References
- 0
- Citations by year
- 2022: 1
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bipolar disorder, environmental stress, DNA methylation, longitudinal course, dopamine signaling, brain development, neuropsychiatric disorders, preclinical models, genetic engineering, pharmacological manipulation
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