Mouse models of age-related macular degeneration
Abstract
Recent advances in genetic technologies have greatly accelerated our ability to find disease-related genes and to generate animal models. The availability of ocular tissues with known genetic diseases are greatly contributing to our understanding of retinal disease processes including age-related macular degeneration (AMD), and panretinal and cone degenerations. While the macula is a highly specialised area of the retina not present in many mammals, the use of animal models such as mouse strains will give basic physiology and visual processing genetics relevant to human AMD. This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations.
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Certain mouse models of retinal degeneration help provide insight into the molecular pathology of photoreceptor loss in AMD.
“certain mouse models of retinal degeneration help provide insight into the molecular pathology of photoreceptor loss in AMD”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Rakoczy et al., 2006
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References 73 · Cited by 107
- Authors
- Elizabeth Rakoczy, P., Yu, M. J. T., Nusinowitz, S., Chang, B., & Heckenlively, J. R.
- Affiliations
- Lions Eye Institute (AU)
- University of California, Los Angeles (US)
- Jackson Laboratory (US)
- University of Michigan (US)
- ORCID
- Chang, Bo
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 82
- Issue
- 5
- Pages
- 741-752
- ISSN
- 0014-4835 (ISSN-L)
- OpenAlex
- W2086868386
- Cited by
- 107
- References
- 73
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 4 · 2012: 7
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Eye Research (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- National Eye Institute (R01EY007758, R01 EY7758-16)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, mouse model, retinal degeneration, cone degeneration, macula, genetic disease models, retinal physiology
- MeSH terms
- Animals, Disease Models, Animal, Fluorescein Angiography, Macular Degeneration, Mice, Transgenic, Retinal Degeneration, Genetic Predisposition to Disease, Choroidal Neovascularization, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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