The search for DAF-16/FOXO transcriptional targets: Approaches and discoveries

Murphy, Coleen T.·2006·Experimental Gerontology

Cited by (189)

Items 101–189 of 189

  1. Role/s of ‘Antioxidant’ Enzymes in Ageing
    Elizabeth A. Veal, Thomas Jackson, Heather R. Latimer · 2018 · Sub-cellular biochemistry/Subcellular biochemistry
  2. Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review
    Emeka Iweala, Oluwapelumi Eniola Adurosakin, Innocent Ugochukwu, Conrad Asotie Omonhinmin, Omoremime Elizabeth Dania, Eziuche Amadike Ugbogu · 2024 · Sci
  3. Correction: Characterization of PUD-1 and PUD-2, Two Proteins Up-Regulated in a Long-Lived daf-2 Mutant
    Yue‐He Ding, Yunguang Du, S.C. Luo, Yuxin Li, Tie‐Mei Li, Sawako Yoshina, Xing Wang, Karsten Klage, Shohei Mitani, Keqiong Ye et al. · 2013 · PLoS ONE
  4. Longevity Effect of Liuwei Dihuang in Both Caenorhabditis Elegans and Aged Mice
    Weidong Chen, Jinzeng Wang, Jiahao Shi, Xu Yang, Ping Yang, Ning Wang, Sai Yang, Tianpei Xie, Hua Yang, Mengjie Zhang et al. · 2018 · Aging and Disease
  5. Low methyl-esterified ginseng homogalacturonan pectins promote longevity of Caenorhabditis elegans via impairing insulin/IGF-1 signalling
    Jiayi Wang, Yuan Wang, Xuejiao Xu, Chengcheng Song, Yuwei Zhou, Dongxue Xue, Zhangkai Feng, Yifa Zhou, Xiaoxue Li · 2024 · Carbohydrate Polymers
  6. LIN‐28 balances longevity and germline stem cell number in Caenorhabditis elegans through let‐7/AKT/DAF‐16 axis
    Dan Wang, Lei Hou, Shuhei Nakamura, Ming Su, Fang Li, Weiyang Chen, Yizhen Yan, Christopher D. Green, Di Chen, Hong Zhang et al. · 2016 · Aging Cell
  7. 20-hydroxyecdysone regulates expression of methioninesulfoxide reductases through transcription factor FOXO in the red flour beetle, Tribolium castaneum
    Caihong Ji, Nan Zhang, Heng Jiang, Xiangkun Meng, Huichen Ge, Xuemei Yang, Xin Xu, Kun Qian, Yoonseong Park, Zheng Yang et al. · 2021 · Insect Biochemistry and Molecular Biology
  8. Mechanistic Insights into Aging, Cell-Cycle Progression, and Stress Response
    Spike D. L. Postnikoff, Troy A. A. Harkness · 2012 · Frontiers in Physiology
  9. Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal
    Magdalena Chechlińska, Jan Konrad Siwicki, Monika Goś, Małgorzata Oczko‐Wojciechowska, Michał Jarząb, Aleksandra Pfeifer, Barbara Jarząb, Jan A. Steffen · 2009 · BMC Genomics
  10. Neuroprotective effects and mechanism of cognitive-enhancing choline analogs JWB 1-84-1 and JAY 2-22-33 in neuronal culture and Caenorhabditis elegans
    Roongpetch Keowkase, Marwa A. Aboukhatwa, Bao-Ling Adam, J Warren Beach, Alvin V. Terry, Jerry J Buccafussco, Yuan Luo · 2010 · Molecular Neurodegeneration
  11. The Conserved PBAF Nucleosome-Remodeling Complex Mediates the Response to Stress in Caenorhabditis elegans
    Aleksandra Kuzmanov, Evguenia I. Karina, Natalia V. Kirienko, David S. Fay · 2014 · Molecular and Cellular Biology
  12. Regulation of UNC-40/DCC and UNC-6/Netrin by DAF-16 promotes functional rewiring of the injured axon
    Atrayee Basu, Sibaram Behera, Smriti Bhardwaj, Shirshendu Dey, Anindya Ghosh‐Roy · 2021 · Development
  13. Diterpenoid Caesalmin C Delays Aβ-Induced Paralysis Symptoms via the DAF-16 Pathway in Caenorhabditis elegans
    Zongping Zhang, Xue Bai, Wen-Bo Cui, Xiaohan Chen, Xu Liu, Dejuan Zhi, Zhan‐Xin Zhang, Dong‐Qing Fei, Dongsheng Wang · 2022 · International Journal of Molecular Sciences
  14. Comparative Transcriptomics Identifies Neuronal and Metabolic Adaptations to Hypergravity and Microgravity in Caenorhabditis elegans
    Craig R. G. Willis, Nathaniel J. Szewczyk, Sylvain V. Costes, Ingrid A. Udranszky, Sigrid S. Reinsch, Timothy Etheridge, Catharine A. Conley · 2020 · iScience
  15. Genome-Scale Studies of Aging: Challenges and Opportunities
    Mark A. McCormick, Brian Keith Kennedy · 2012 · Current Genomics
  16. Anoxia, acidosis, and intergenic interactions selectively regulate methionine sulfoxide reductase transcriptions in mouse embryonic stem cells
    Chi Zhang, Pingping Jia, Yuanyuan Jia, Yuejin Li, Keith A. Webster, Xupei Huang, Mohan P. Achary, Sharon L. Lemanski, Larry F. Lemanski · 2010 · Journal of Cellular Biochemistry
  17. Sorafenib extends the lifespan of C. elegans through mitochondrial uncoupling mechanism
    Lu-Yao Zheng, Yan-Xin Da, Xiu Luo, Xiao Zhang, Zhijie Sun, De‐Li Dong · 2024 · Free Radical Biology and Medicine
  18. Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A2 Receptors in Urothelial Cancer
    Philip M. Sobolesky, Perry V. Halushka, Elizabeth S. Garrett-Mayer, Michael Timothy Smith, Omar Moussa · 2014 · PLoS ONE
  19. Chromatin: the old and young of it
    Felicity J. Emerson, Siu Sylvia Lee · 2023 · Frontiers in Molecular Biosciences
  20. Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways
    Linda P. O’Reilly, Joshua A. Benson, Erin E. Cummings, David H. Perlmutter, Gary A. Silverman, Stephen C. Pak · 2014 · Expert Opinion on Drug Discovery
  21. Characterization of PUD-1 and PUD-2, Two Proteins Up-Regulated in a Long-Lived daf-2 Mutant
    Yue‐He Ding, Yunguang Du, Shukun Luo, Yuxin Li, Tie‐Mei Li, Sawako Yoshina, Xing Wang, Karsten Klage, Shohei Mitani, Keqiong Ye et al. · 2013 · PLoS ONE
  22. Assessment on chronic and transgenerational toxicity of methamphetamine to Caenorhabditis elegans and associated aquatic risk through toxicity indicator sensitivity distribution (TISD) analysis
    Zhenglu Wang, Shuiping Dai, Jinze Wang, Wei Du, Lin Zhu · 2021 · Environmental Pollution
  23. Towards understanding the lifespan extension by reduced insulin signaling: bioinformatics analysis of DAF-16/FOXO direct targets in Caenorhabditis elegans
    Yanhui Li, Gaigai Zhang · 2016 · Oncotarget
  24. Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1
    Guillermo Martínez-Corrales, Mengjia Li, Tatiana Svermova, Alex Goncalves, Diana Voicu, Adam J Dobson, Tony D. Southall, Nazif Alic · 2022 · Nature Aging
  25. Planococcus maritimu ML1206 Strain Enhances Stress Resistance and Extends the Lifespan in Caenorhabditis elegans via FOXO/DAF-16
    Jing-Shan Wu, Chun-Guo Lin, Changlong Jin, Yanxia Zhou, Ying-Xiu Li · 2022 · Marine Drugs
  26. In vivo neuroprotective capacity of a Dunaliella salina extract - comprehensive transcriptomics and metabolomics study
    Alberto Valdés, José David Sánchez-Martínez, Rocío Gallego, Elena Ibáñez, Miguel Herrero, Alejandro Cifuentes · 2024 · npj Science of Food
  27. Antidepressants Modulate Intracellular Amyloid Peptide Species in N2a Neuroblastoma Cells
    Marwa A. Aboukhatwa, Yuan Luo · 2011 · Journal of Alzheimer s Disease
  28. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans
    Michael Hoffmann, Sebastian Honnen, Ertan Mayatepek, Wim Wätjen, Werner J.H. Koopman, Olaf Bossinger, Felix Distelmaier · 2012 · Experimental Gerontology
  29. Apoptosis contributes to protect germ cells from the oogenic germline starvation response but is not essential for the gonad shrinking or recovery observed during adult reproductive diapause in C. elegans
    E. Carranza-García, Rosa Estela Navarro · 2019 · PLoS ONE
  30. Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function
    Marc Tatar · 2021 · Frontiers in Endocrinology
  31. Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans
    Yanli Wang, Cangsang Xie, Zhiqing Diao, Bin Liang · 2017 · Molecules
  32. Chitosan nanoparticles encapsulated Piper betle essential oil alleviates Alzheimer's disease associated pathology in Caenorhabditis elegans
    Velumani Muthusamy, Govindhan Thiruppathi, Amirthalingam Mohankumar, Anila Pottanthara Ashokan, Hema Thangavel, Palanisamy Sundararaj, Paramasivam Premasudha · 2024 · International Journal of Biological Macromolecules
  33. Blumea laciniata protected Hep G2 cells and Caenorhabditis elegans against acrylamide-induced toxicity via insulin/IGF-1 signaling pathway
    Lijun Zhou, Siyuan Luo, Xiaoju Wang, Yiling Zhou, Yuan Zhang, Shuai Zhu, Tao Chen, Shiling Feng, Ming Yuan, Chunbang Ding · 2021 · Food and Chemical Toxicology
  34. Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in caenorhabditis elegans
    Binggen Zhu, Ping Yang, Mammat Nurahmat, Hui Ding, HE Jun-min, Yong Ri Qian, Jian Fei, Kaiser Abdukerim · 2015 · BMC Complementary and Alternative Medicine
  35. The Insulin/IGF Signaling Regulators Cytohesin/GRP-1 and PIP5K/PPK-1 Modulate Susceptibility to Excitotoxicity in C. elegans
    Nazila Tehrani, John Smith Del Rosario, Moises Dominguez, Robert Gordon Kalb, Itzhak Mano · 2014 · PLoS ONE
  36. Nontranscriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis
    Hiroaki Daitoku, Yuta Kaneko, Kenji Yoshimochi, Kaori Matsumoto, Sho Araoi, Jun-Ichi Sakamaki, Yuta Takahashi, Akiyoshi Fukamizu · 2016 · Molecular and Cellular Biology
  37. Combined informatic and expression screen identifies the novel DAF-16 target HLH-13
    Nicole F. Liachko, Rachel A. Davidowitz, Siu Sylvia Lee · 2008 · Developmental Biology
  38. Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster
    Dobril K. Ivanov, Irene Papatheodorou, Matthias Ziehm, Janet M. Thornton · 2013 · Molecular BioSystems
  39. Temporal pattern of neuronal insulin release during Caenorhabditis elegans aging: Role of redox homeostasis
    Alicia N. Minniti, Héctor Arriagada, Soledad Zúñiga, Marcela Bravo‐Zehnder, Iván E. Alfaro, Rebeca Aldunate · 2018 · Aging Cell
  40. FoxO transcription factors in the control of redox homeostasis and fuel metabolism
    Sarah Tauber, Holger Steinbrenner, Lars‐Oliver Klotz · 2019 · Elsevier eBooks
  41. Detoxification-related gene expression accompanies anhydrobiosis in the foliar nematode ( Aphelenchoides fragariae )
    Zhen Fu, Paula A. Agudelo, Christina E. Wells · 2020 · Journal of Nematology
  42. ins-7 Gene Expression Is Partially Regulated by the DAF-16/IIS Signaling Pathway in Caenorhabditis elegans under Celecoxib Intervention
    Shanqing Zheng, Sentai Liao, Yuxiao Zou, Zhi Qu, Fan Liu · 2014 · PLoS ONE
  43. Characterization of Genetic Variation in the Forkhead Box Class O3 Gene ( FOXO3 ) in Sheep
    S. O. Byun, Huitong Zhou, Jon G. H. Hickford · 2011 · DNA and Cell Biology
  44. Biology of Aging
    Huber R. Warner · 2011 · Springer eBooks
  45. Learning and Memory: Mind over Matter in C. elegans
    Menachem Katz, Shai Shaham · 2019 · Current Biology
  46. Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism
    Ava Handley, Qiuli Wu, Tessa Sherry, Rebecca Cornell, Roger Pocock · 2022 · PLoS Biology
  47. Using Genomic Tools to Study Regulatory Evolution
    Yoav Gilad · 2012 · Methods in molecular biology
  48. Independent Control of Aging and Axon Regeneration
    Stéphane Belin, Michael W. Norsworthy, Zhigang He · 2014 · Cell Metabolism
  49. An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan
    Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A. Parkhitko · 2025 · PLoS Genetics
  50. Developmental decisions
    David V. Tobin, Richard Mako Saito · 2012 · Cell Cycle
  51. The C. elegans truncated insulin receptor DAF-2B regulates survival of L1 arrested larvae
    Bryan Martinez, Matthew S. Gill · 2023 · PLoS ONE
  52. The Roles of Distinct Transcriptional Factors in the Innate Immunity of C. elegans
    Muhammad Irfan Afridi, Haijun Tu · 2025 · Cells
  53. ROS-mediated relationships between metabolism and DAF-16 subcellular localization in Caenorhabditis elegans revealed by a novel fluorometric method
    Martha N. Mendelski, Alex Keshet, Nadine Hoffschröer, Thiago Strieder, Sarah A. Winter, Rüdiger J. Paul · 2019 · Cellular Signalling
  54. DAF-16 and PQM-1: Partners in longevity
    Ronald G. Tepper, Coleen Tara Murphy, Harmen J. Bussemaker · 2014 · Aging
  55. Uncovering the Molecular Pathways Implicated in the Anti-Cancer Activity of the Imidazoquinoxaline Derivative EAPB02303 Using a Caenorhabditis elegans Model
    Perla Makhoul, Simon Galas, Stéphanie Paniagua-Gayraud, Carine Deleuze‐Masquéfa, Hiba El Hajj, Pierre‐Antoine Bonnet, Myriam Richaud · 2024 · International Journal of Molecular Sciences
  56. Role of Oxidative Stress in Aging
    Daniela Knoefler, Heather L. Tienson, Ursula Jakob · 2013 · Springer eBooks
  57. The Role of Lifestyle in Modulating the Gut Microbiome
    Noor Muhammad, Areeba Saeed, Aqsa Ashfaq, Syed Haider Ali Shah, Husna Jurrat, Waiza Ansar, Zahid Nazir, Rabbia Musaddaq, Hubza Ruatt Khan, Iram Liaqat · 2025 · Futuristic Biotechnology
  58. Unraveling the mode of action of medicinal plants in delaying age-related diseases using model organisms
    Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Pulikkottil Stanes Rosmol, Tewin Tencomnao · 2020 · Elsevier eBooks
  59. The role of oxidative stress in C. elegans aging
    Maike Thamsen · 2011 · Gutenberg Open Science
  60. Therapeutic potential of longevity modulators as neuroprotective targets in neurodegenerative disease
    Rafael P. Vázquez‐Manrique, Cendrine Tourette, Christian Néri · 2012 · Research and perspectives in Alzheimer's disease
  61. Biology of Aging
    Huber R. Warner, Felipe Sierra, LaDora V. Thompson · 2010 · Elsevier eBooks
  62. Pentagalloyl glucose enhanced the stress resistance to delay aging process in Caenorhabditis elegans
    Jingrui Luo, Xiaoying Zhang, Wei Li, Yaqi Lan, Fangwen Li, Jie Xiao, Yong Cao, Guo Liu, Yunjiao Chen · 2024 · Process Biochemistry
  63. Moving beyond the current limits of data analysis in longevity and healthy lifespan studies
    Wilson Wen Bin Goh, Subhash Thalappilly, Guillaume Thibault · 2019 · Drug Discovery Today
  64. Amphioxus muscle transcriptomes reveal vertebrate-like myoblast fusion genes and a highly conserved role of insulin signalling in the metabolism of muscle
    Madeleine E Aase-Remedios, Clara Coll-Lladó, David E. K. Ferrier · 2022 · BMC Genomics
  65. Chaperone-directed ubiquitylation maintains proteostasis at the expense of longevity
    Wojciech Pokrzywa, Robin Lorenz, Thorsten Hoppe · 2017 · Worm
  66. A Novel C. elegans Memory Type Mediated by an Insulin/Phospholipase C Pathway
    Daniel M. Merritt, Alexandra Udachina, Ninon Freidel, Sylvia M. T. Almeida, Yan Ming Anson Lau, Matthew Lee, Derek van der Kooy · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Mutation of an insulin-sensitive Drosophila insulin-like receptor mutant requires methionine metabolism reprogramming to extend lifespan
    Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A. Parkhitko · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  68. Funktionelle Analyse der C. elegans Gene vang-1, atad-3 und mics-1 in Bezug auf Alterung und Stressresistenz
    Sebastian Honnen · 2012 · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
  69. Mechanisms Linking Lipid Metabolism and Longevity in Yeast
    Simon D. Bourque · 2011 · Spectrum Research Repository (Concordia University)
  70. Plant-based Diets and Low-Insulin Lifestyles May Suppress Oxidative Stress By Disinhibiting FOXO3a
    Mark Frederick McCarty · 2011
  71. Functional Characterization of a FoxO Target Gene
    Ian G. Waters · 2014 · Deep Blue (University of Michigan)
  72. Ecological genomics of nematode responses to different bacterial environments
    Joseph D. Coolon · 2008 · K-State Research Exchange (Kansas State University)
  73. UNIVERSIDADE FEDERAL DE OURO PRETO NÚCLEO DE PESQUISAS EM CIÊNCIAS BIOLÓGICAS PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS BIOLÓGICAS
    Rafael Rodrigues da Silva, André Talvani, Maria Terezinha Bahia, Ouro Preto · 2010
  74. Role of cardiac FoxO1 in conditions of insulin resistance, nutrient excess, and diabetes
    Prasanth Puthanveetil · 2012 · cIRcle (University of British Columbia)
  75. Glucose Induces Sensitivity to Oxygen Deprivation and Alters Gene Expression in Caenorhabditis Elegans
    Anastacia M. Garcia · 2015
  76. The Presynaptic F-box Protein FSN-1 Regulates Synapse Development via Retrograde Insulin Signaling in Caenorhabditis elegans
    Hwang, Christine · 2010 · TSpace (University of Toronto)
  77. The F-box Protein FSN-1 Governs Presynaptic Development in Caenorhabditis elegans
    Nicholas A. Watkins · 2011 · TSpace (University of Toronto)
  78. Insulin Signaling Promotes Ras/MAPK Cascade Activity by Inhibiting the FOXO Transcription Factor DAF-16
    Mathew Hall · 2014 · TSpace (University of Toronto)
  79. New Genes that Act Downstream of a FoxO Transcription Factor to Regulate Diapause and Longevity
    Joseph C.P. Kruempel · 2018 · Deep Blue (University of Michigan)
  80. Faculty Opinions recommendation of A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
    Morris Maduro · 2009 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  81. Plant bioactives in immune modulation and their role in antiaging
    Yasemi̇n Aydin, Yasemin Ulku Dikbasan, Banu Orta Yılmaz · 2022 · Elsevier eBooks
  82. Stress-induced neurodegeneration and behavioral alterations in Caenorhabditis elegans: Insights into the evolutionary conservation of stress-related pathways and implications for human health
    Toheeb Olalekan Oyerinde, Victor Ebube Anadu, Tobiloba Samuel Olajide, Olayemi Kafilat Ijomone, Oritoke Modupe Okeowo, Omamuyovwi M. Ijomone · 2025 · Progress in brain research
  83. Neurorestorative properties of 2-butoxytetrahydrofuran from Holothuria scabra via activation of stress resistance and detoxification in a 6-OHDA-induced C. elegans model of Parkinson’s disease
    Sukrit Promtang, Tanatcha Sanguanphun, Pawanrat Chalorak, Darunee Rodma, Rungsarit Sunan, Laurence S. Pe, Nakorn Niamnont, Supin Chompoopong, Prasert Sobhon, Krai Meemon · 2025 · Biomedicine & Pharmacotherapy
  84. Using the Experimental Evolution of Long-Lived Yeast Species for Testing Evolutionary Theories of Aging
    Anastasia Glebov · 2011 · Spectrum Research Repository (Concordia University)
  85. Additional file 1 of Amphioxus muscle transcriptomes reveal vertebrate-like myoblast fusion genes and a highly conserved role of insulin signalling in the metabolism of muscle
    Aase-Remedios, Madeleine E., Clara Coll-Lladó, David E. K. Ferrier · 2022 · Figshare
  86. The role of serotoninergic neurons in amyotrophic lateral sclerosis
    Hajer El Oussini · 2016 · theses.fr (ABES)
  87. Conditional truncation of the FUS protein in mice : a new animal model of the ALS/FTD continuum
    Jelena Scekic‐Zahirovic · 2016 · theses.fr (ABES)
  88. Molecular and Multiomics (Genomics, Proteomics, Transcriptomics) Approaches for Enhancing Anti-aging Properties of Plant Secondary Metabolites
    Iliassou Lah Mouafon, Guy Roland Ebede, Merveilles A. Bella, David R. Katerere, Gaétan Bayiha Ba Njock, Joseph Thierry Ndongo · 2026 · Springer eBooks
  89. Antioxidant Activity and DAF-16-Associated Lifespan-Promoting Effects of Essential Oil from Melastoma sanguineum Sims in Caenorhabditis elegans
    Xue Cui, Xu Liu, Jing-Shan Wu, Ying Han, Heng-Jia Wei, Ying-Xiu Li · 2026 · Molecules