Evidence for differential regulation of lactate metabolic properties in aged and unloaded rat skeletal muscle
Abstract
Skeletal muscles of elderly individuals show fatigue resistance and reduced lactate accumulation compared with those of young subjects during activities that recruit a small amount of muscle mass. To explore the mechanism underlying the functional changes in aged muscle, we focused on lactate metabolic properties, including monocarboxylate transporter (MCT) 1 and MCT4, in muscles from old and young control rats and hindlimb-suspended young rats. MCT1 expression was lower in soleus (SOL) of old rats than in SOL of young control rats, but was similar in young control and hindlimb-suspended rats. MCT4 expression was lower in extensor digitorum longus (EDL) of old rats than in that of young control rats, but did not differ between young control and hindlimb-suspended rats. The ratio of lactate dehydrogenase to citrate synthase activities was higher in SOL of hindlimb-suspended and old rats than in SOL of young control rats, and was lower in EDL of old rats than in those of young control and hindlimb-suspended rats. Our data suggest that aging causes metabolic changes that can reduce lactate accumulation during exercise and increase fatigue resistance in skeletal muscle, and that these changes result from aging rather than from inactivity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise training increases MCT1 levels and enhances lactate transport to muscle, whereas MCTs are reduced in aging muscle, thus reducing lactate levels and increasing skeletal muscle fatigue.
“Exercise training increases MCT1 levels and enhances lactate transport to muscle, whereas MCTs are reduced in aging muscle, thus reducing lactate levels and increasing skeletal muscle fatigue [116].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [116]
The citation lists haven’t been fetched yet
References 53 · Cited by 26
- Authors
- Masuda, S., Hayashi, T., Egawa, T., & Taguchi, S.
- Affiliations
- Kyoto University (JP)
- Naragakuen University (JP)
- Corresponding author
- Hayashi, Tatsuya
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 44
- Issue
- 4
- Pages
- 280-288
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W1990080814
- Cited by
- 26
- References
- 53
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2022: 2 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 2
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, lactate metabolism, monocarboxylate transporters, MCT1, MCT4, hindlimb unloading, muscle inactivity, fatigue resistance, lactate accumulation, lactate dehydrogenase, citrate synthase, soleus muscle, extensor digitorum longus, physical activity
- MeSH terms
- Monocarboxylate Transport Protein 1, Aging, Animals, Hindlimb, Male, Muscle Contraction, Muscle Proteins, Blotting, Western, Rats, Wistar, Muscle, Skeletal, Lactic Acid, Monocarboxylic Acid Transporters, Symporters, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
