Telomere length in Parkinson's disease: A meta-analysis
Open accessAbstract
Parkinson's disease (PD) is a common and severe movement disorder. Differences in telomere length (TL) have been reported as possible risk factors for several neuropsychiatric disorders, including PD. Results from published studies for TL in PD are inconsistent, highlighting the need for a meta-analysis. In the current work, a meta-analysis of published studies for TL in PD was carried out. PubMed, Web of Science and Google Scholar databases were used to identify relevant articles that reported TL in groups of PD patients and controls. A random-effects model was used for meta-analytical procedures. The meta-analysis included eight primary studies, derived from populations of European and Asian descent, and did not show a significant difference in TL between 956 PD patients and 1284 controls (p value: 0.246). Our results show that there is no consistent evidence of shorter telomeres in PD patients and suggest the importance of future studies on TL and PD that analyze other populations and also include assessment of TL from different brain regions.
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There is no clear evidence of telomere length changes in Parkinson's disease patients.
“Although there is no clear evidence of telomere length changes in patients with Parkinson’s disease170”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [170]
There is no difference in telomere length between PD patients and age-matched controls.
“A meta-analysis by Forero et al., incorporating all these studies, showed that there is no difference in telomere length between PD patients and age-matched controls [270].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [270]
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References 23 · Cited by 70
- Authors
- Forero, D. A., González-Giraldo, Y., López-Quintero, C., Castro-Vega, L. J., Barreto, G. E., & Perry, G.
- Affiliations
- Universidad Antonio Nariño (CO)
- Pontificia Universidad Javeriana (CO)
- The University of Texas at San Antonio (US)
- Corresponding author
- Forero, Diego A.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 75
- Pages
- 53-55
- ISSN
- 0531-5565 (ISSN-L)
- PMC
- PMC4786001
- OpenAlex
- W2225243193
- Cited by
- 70
- References
- 23
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 4 · 2023: 6 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 8 · 2017: 3 · 2016: 4
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Colciencias (20131079, 20131080)
- VCTI-UAN
- Centro de Estudios Interdisciplinarios Básicos y Aplicados
- National Institute on Drug Abuse (T32DA021129)
- Pontificia Universidad Javeriana
- NIH (G12-MD007591)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Parkinson's disease, telomere length, telomere shortening, aging, neurodegeneration, biomarkers, brain regions
- MeSH terms
- Humans, Parkinson Disease, Risk Factors, Case-Control Studies, Telomere, Telomere Shortening
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