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Cited by 227Nutrition and Health in AgingFrailty in Older AdultsMuscle Physiology and Disorders

The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.

Muscle function and fat content in relation to sarcopenia, obesity and frailty of old age — An overview

Buch, Assaf, Carmeli, Eli, Boker, Lital Keinan, Marcus, Yonit, Shefer, Gabi, Kis, Ofer, Berner, Yitshal, Stern, Naftali·2016·Experimental Gerontology
DOI 10.1016/j.exger.2016.01.008
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Abstract

Background and aim In western countries, the proportion of people over age 60 is increasing faster than any other group. This is linked to higher rates of obesity. Older age, co-morbidities and obesity are all associated with frailty syndrome. In the core of both frailty and sarcopenia there are dysfunction and deterioration of the muscle and the fat tissues. This overview interlinks the phenotypes presented in older adults such as sarcopenia and frailty-alone and with relation to obesity, muscle function and fat tissue accumulation.Recent findings Observational studies have well described the loss of muscle mass and strength through the years of adult life, both components of frailty and sarcopenia. They have shown that these changes are associated with dysmetabolism and functional deterioration, independent of common explanatory variables. In the metabolic mechanism core of this link, insulin resistance and higher ectopic fat accumulation may play a role. Basic experiments have partially validated this hypothesis. Whether there is a synergistic effect of obesity and frailty phenotype on morbidity risk is still questionable and currently under investigation; however, few cohort studies have shown that the frail-obese or sarcopenic-obese group have higher probability for metabolic complications.Summary Muscle mass loss and fat accumulation in the muscle in the elderly, with or without the presence of obesity, may explain some of the functional and metabolic defects shown in the frail, sarcopenic population.

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Metadata

Authors
Buch, A., Carmeli, E., Boker, L. K., Marcus, Y., Shefer, G., Kis, O., Berner, Y., & Stern, N.
Affiliations
  • Tel Aviv University (IL)
  • Tel Aviv Sourasky Medical Center (IL)
Corresponding author
Buch, Assaf
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2016-04
Volume
76
Pages
25-32
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/j.exger.2016.01.008
OpenAlex
W2270129711
Cited by
227
References
75
Citations by year
2026: 13 · 2025: 22 · 2024: 34 · 2023: 8 · 2022: 24 · 2021: 30 · 2020: 31 · 2019: 23 · 2018: 16 · 2017: 14 · 2016: 12
FWCI
2.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sarcopenia, frailty, obesity, muscle function, fat tissue accumulation, muscle mass loss, muscle strength, insulin resistance, ectopic fat, metabolic complications, older adults, aging
MeSH terms
Age Factors, Aged, Aging, Energy Metabolism, Humans, Insulin Resistance, Middle Aged, Obesity, Phenotype, Risk Factors, Geriatric Assessment, Frail Elderly, Muscle, Skeletal, Adiposity, Muscle Strength, Sarcopenia

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