Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant

Schmidt, Hauke; Raasch, Jenni; Merkler, Doron; Klinker, Florian; Krauss, Sandra; Brück, Wolfgang; Prinz, Marco

doi:10.1016/j.expneurol.2008.12.002

Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant

The type I interferons, interferon-beta and alpha (IFN-beta, IFN-alpha), are widely used for the treatment of autoimmune demyelination in the central nervous system (CNS). Their effects on de- and remyelination through the broadly expressed type I IFN receptor (IFNAR), however, are highly specula…