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Cited by 20Parasitic infections in humans and animalsHelminth infection and controlParasites and Host Interactions

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Effect of dexamethasone on albendazole cysticidal activity in experimental cysticercosis by Taenia crassiceps in BALB/c mice: In vitro and in vivo evaluation

Palomares-Alonso, Francisca, Toledo, Andrea, Palencia Hernández, Guadalupe, Jung-Cook, Helgi, Fleury, Agnès·2020·Experimental Parasitology
DOI 10.1016/j.exppara.2019.107801
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Abstract

Taenia solium is a parasite whose larvae (cysticerci) can locate in the central nervous system of humans and cause neurocysticercosis (NC). The introduction of cysticidal drugs such as albendazole (ABZ) for the treatment of NC has significantly improved its prognosis. However, treatment is not always effective, and the high levels of corticosteroids used to prevent inflammatory complications in this disease could be, partly, the cause of this observation. In this context, this study investigated, using the experimental mouse model of intraperitoneal infection with Taenia crassiceps, the influence of corticosteroid administration on the therapeutic efficacy of ABZ. We evaluated and compared the effects of ABZ, dexamethasone (DXM) and their combination (ABZ + DXM) on cyst viability, both in vitro and in vivo. Serum levels of IL-4, IFN-gamma, IL-6 and IL-10 were evaluated in the in vivo study. Results showed that the treatment with ABZ, in vitro and in vivo, was associated with a high number of parasites deaths. Concomitant treatment with DXM did not alter ABZ in vitro cysticidal activity but reduced its effectiveness significantly in the in vivo experimental model. Cytokine serum levels did not change significantly in treated mice compared to the controls. The results of this study are relevant as they indicate a negative effect of corticosteroids on the efficacy of cysticidal therapy. In human neurocysticercosis, control of inflammation is of great importance to most patients in order to avoid complications. Corticosteroids are generally used for this purpose and the results of this study demonstrate the need to find other therapeutic strategies. Further studies are needed to better understand the mechanisms involved.

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Metadata

Authors
Palomares-Alonso, F., Toledo, A., Palencia Hernández, G., Jung-Cook, H., & Fleury, A.
Affiliations
Instituto Nacional de Neurología y Neurocirugía (MX)
Corresponding author
Fleury, Agnès
ORCID
Venue
Experimental Parasitology
Publisher
Elsevier BV
Published
2020-01
Volume
208
Pages
107801
ISSN
0014-4894 (ISSN-L)
DOI
10.1016/j.exppara.2019.107801
OpenAlex
W2987763648
Cited by
20
References
0
Citations by year
2025: 2 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 5
FWCI
2.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Experimental Parasitology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic infections in humans and animals
  • Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords
dexamethasone, albendazole, Taenia crassiceps, cysticercosis, neurocysticercosis, corticosteroids, cysticidal activity, drug interactions, cytokines, inflammation, antiparasitic treatment
MeSH terms
Animals, Anthelmintics, Anti-Inflammatory Agents, Cysticercosis, Dexamethasone, Drug Interactions, Enzyme-Linked Immunosorbent Assay, Female, Interferon-gamma, Mice, Inbred BALB C, Taenia, Albendazole, Interleukin-4, Interleukin-6, Interleukin-10, Mice

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CoChat. (2026). Citation check: Effect of dexamethasone on albendazole cysticidal activity in experimental cysticercosis by Taenia crassiceps in BALB/c mice: In vitro and in vivo evaluation. https://app.cochat.ai/papers/10.1016/j.exppara.2019.107801
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Palomares-Alonso, F., Toledo, A., Palencia Hernández, G., Jung-Cook, H., & Fleury, A. (2020). Effect of dexamethasone on albendazole cysticidal activity in experimental cysticercosis by Taenia crassiceps in BALB/c mice: In vitro and in vivo evaluation. Experimental Parasitology. https://doi.org/10.1016/j.exppara.2019.107801