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Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions
Abstract
Inhibitory effect of the n-hexane, dichloromethane, ethyl acetate, and ethanol extracts from Anethum graveolens L. (dill) cultivated under organic (AG-O) and conventional (AG-C) conditions was tested against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase at 200 μg mL⁻¹. Their antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), N,N-dimethyl-p-phenylendiamine (DMPD), and nitric oxide (NO) radical scavenging assays as well as ferric ion-chelation capacity, ferric-(FRAP), and phosphomolybdenum-reducing antioxidant power (PRAP). The phytochemical analyses have been performed on both of the plant samples. GC-MS analysis pointed out that α-phellandrene was the main component in both of the essential oils in varying amounts (47.75% for AG-O and 27.94% for AG-C), while oleic acid was the dominant in the fruit oils of two samples (36.39% for AG-O and 53.87% for AG-C). HPLC analysis showed that both of the extracts contained rosmarinic acid as the major phenolic acid. The extracts inhibited BChE at moderate level, while the ethanol extracts exerted remarkable NO scavenging effect. The results emphasize that cultivation conditions may have effect on bioactivity and phytochemical content on plant samples.
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“A. graveolens has been reported in the literature to exhibit various biological activities, including antimicrobial, antifungal, antioxidant, insecticidal, antiinflammatory, antispasmodic, antidiabetic, anticancer and antihypercholesterolemic properties6,9.”
From Synergistic and antagonistic contributions of main components to the bioactivity profile of Anethum graveolens extract (2025) · cites this paper as [9]
In the citing paper
“Previous literature findings indicate that A. graveolens L. extracts and EO can function as antioxidant and antibacterial agents; also, they may inhibit enzyme activity but these effects are strongly influenced by the extraction procedure and the extract composition [35,36,37,38].”
From Maceration, Soxhlet Extraction, and Steam Hydrodistillation of Anethum graveolens Seeds: Phytochemical Profiles and Cytotoxic Effects (2026) · cites this paper as [35]
In the citing paper
“Previous literature findings indicate that A. graveolens L. extracts and EO can function as antioxidant and antibacterial agents; also, they may inhibit enzyme activity but these effects are strongly influenced by the extraction procedure and the extract composition [35,36,37,38].”
From Maceration, Soxhlet Extraction, and Steam Hydrodistillation of Anethum graveolens Seeds: Phytochemical Profiles and Cytotoxic Effects (2026) · cites this paper as [35]
In the citing paper
“Previous literature findings indicate that A. graveolens L. extracts and EO can function as antioxidant and antibacterial agents; also, they may inhibit enzyme activity but these effects are strongly influenced by the extraction procedure and the extract composition [35,36,37,38].”
From Maceration, Soxhlet Extraction, and Steam Hydrodistillation of Anethum graveolens Seeds: Phytochemical Profiles and Cytotoxic Effects (2026) · cites this paper as [35]
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Research works printed but not linked: 32
- Amin, 2007, Chemical and biological study of aerial parts of dill (Anethum graveolens L), Egyptian J. Biomed. Sci., 23, 1
- Badar, 2008, Characteristics of Anethum graveolens (Umbelliferae) seed oil: extraction, composition and antimicrobial activity, Int. J. Agric. Biol., 10, 329
- Blois, 1958, Antioxidant determinations by the use of a stable free radical, Nature, 181, 1199, 10.1038/1811199a0 · DOI
- Bonesi, 2010, Acetylcholinesterase and butyrylcholinesterase inhibitory activity of Pinus species essential oils and their constituents, J. Enzyme Inhib. Med. Chem., 25, 622, 10.3109/14756360903389856 · DOI
- Chua, 2008, Antioxidant activities of ethanolic extracts from the twigs of Cinnamomum osmophleum, Bioresour. Technol., 99, 1918, 10.1016/j.biortech.2007.03.020 · DOI
- Dastmalchi, 2009, Acetylcholinesterase inhibitory-guided fractionation of Melissa officinalis L, Bioorg. Med. Chem., 17, 867, 10.1016/j.bmc.2008.11.034 · DOI
- Ellman, 1961, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem. Pharmacol., 7, 88, 10.1016/0006-2952(61)90145-9 · DOI
- Falcioni, 2002, Antioxidant activity of wheat sprouts extract in vitro: inhibition of DNA oxidative damage, J. Food Sci., 67, 2918, 10.1111/j.1365-2621.2002.tb08838.x · DOI
- Heamalatha, 2011, Pharmacognostical, pharmacological, investigation on Anethum graveolens Linn: a review, Res. J. Pharm. Biol. Chem. Sci., 2, 564
- Jinesh, 2010, Comparative evaluation of antioxidant properties of edible and non-edible leaves of Anethum graveolens Linn, Indian J. Nat. Prod. Resour., 1, 168
- Khalid, 2005, Chemical constituents of seed oils/meals of Pakistani Umbelliferae species as potential industrial raw material, J. Chem. Soc. Pak., 27, 358
- Khan, 2009, Cholinesterase inhibitory activities of some flavonoid derivatives chosen xanthone and their molecular docking studies, Chem.-Biol. Interact., 181, 2009
- Koenig, W.A., Joulain, D., Hochmuth, D.H., 2004. Terpenoids and Related Constituents of Essential Oils. MassFinder 3. In: Hochmuth DH (Ed.), Convenient and Rapid Analysis of GC–MS, Hamburg, Germany.
- Kurkcuoglu, 2003, Composition of volatiles obtained from spices by microdistillation, Chem. Nat. Compd., 39, 355, 10.1023/B:CONC.0000003415.49701.8b · DOI
- Marcocci, 1994, The nitric oxide scavenging properties of Ginkgo biloba extract, Biochem. Biophys. Res. Commun., 201, 748, 10.1006/bbrc.1994.1764 · DOI
- Masuda, 2005, Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica, Biosci. Biotechnol. Biochem., 69, 197, 10.1271/bbb.69.197 · DOI
- Nanasombad, 2009, Antimicrobial, antioxidant and anticancer activities of Thai local vegetables, J. Med. Plants Res., 3, 443
- Orhan, 2006, Recent developments in natural and synthetic drug research for Alzheimer’s disease, Lett. Drug Des. Discovery, 3, 268, 10.2174/157018006776743215 · DOI
- Orhan, 2008, Activity of essential oils and individual components against acetyl- and butyrylcholinesterase, Z. Naturforsch. Sect. C, 63, 547, 10.1515/znc-2008-7-813 · DOI
- Orhan, 2009, Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider, Food Chem. Toxicol., 47, 1747, 10.1016/j.fct.2009.04.023 · DOI
- Ortan, 2009, Contributions to the pharmacognostical study on Anethum graveolens, dill (Apiaceae), Romanian Biotechnol. Lett., 14, 4342
- Oyaizu, 1986, Studies on products of browning reactions–antioxidative activities of products of browning reaction prepared from glucosamine, Jpn. J. Nutr., 44, 307, 10.5264/eiyogakuzashi.44.307 · DOI
- Ozturk, 2007, Determination of phenolic acids by a modified HPLC: its application to various plant materials, J. Liq. Chrom. Relat. Technol., 30, 587, 10.1080/10826070601093911 · DOI
- Pohanka, 2012, Acetylcholinesterase inhibitors: a patent review (2008-present), Expert Opin. Ther. Patents, 22, 871, 10.1517/13543776.2012.701620 · DOI
- Radulescu, 2010, Chemical composition of the volatile oil from different plant parts of Anethum graveolens L. (Umbelliferae) cultivated in Romania, Farmacia, 58, 594
- Savelev, 2004, Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents, Phytother. Res., 18, 315, 10.1002/ptr.1451 · DOI
- Schlesier, 2002, Assessment of antioxidant activity by using different in vitro methods, Free Radical Res., 36, 177, 10.1080/10715760290006411 · DOI
- Sezgin, 2010, Antioxidant and mineral characteristics of some common vegetables consumed in Eastern Turkey, J. Food Agric. Environ., 8, 270
- Stannard, 1982, The multiple uses of dill (Anethum graveolens L.) in medieval medicine, Würzburg Med. Forsch., 24, 411
- Szwajgier, 2012, Screening for cholinesterase inhibitors in selected fruits and vegetables, Electr. J. Polish Agric. Univ., 15, 1
- Thukham-mee, 2012, Evaluation of safety and protective effect of combined extract of Cissampelos pareira and Anethum graveolens (PM52) against age-related cognitive impairment, Evid.-Based Complement. Altern. Med., 2012, 10.1155/2012/674101 · DOI
- Ugulu, 2009, The investigation and quantitative ethnobotanical evaluation of medicinal plants used around Izmir province, Turkey, J. Med. Plants Res., 3, 345
Cited by
Hadi, N., Drioiche, A., Bouchra, E. M., Baammi, S., Abdelaziz Shahat, A., Tagnaout, I., Radi, M., Remok, F., Bouzoubaa, A., & Zair, T. (2024) · Pharmaceuticals · doi:10.3390/ph17070862 · Cited by 30
Kesti Usta, S., Yalçın, E., & Çavuşoğlu, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-07297-8 · Cited by 10
Goldiș, C., Racoviceanu, R., Negrea-Ghiulai, R., Mioc, A., Prodea, A., Atyim, E., Maksimovic, T., Lukinich-Gruia, A. T., Pricop, M.-A., & Șoica, C. (2026) · Molecules · doi:10.3390/molecules31183337
Metadata
- Authors
- Erdogan Orhan, I., Senol, F. S., Ozturk, N., Celik, S. A., Pulur, A., & Kan, Y.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 59
- Pages
- 96-103
- ISSN
- 0278-6915
- Cited by
- 60
- References
- 0
- Language
- en
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- Erdogan Orhan, I., Senol, F. S., Ozturk, N., Celik, S. A., Pulur, A., & Kan, Y. (2013). Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2013.05.053