Determination of dibutyl phthalate neurobehavioral toxicity in mice
Abstract
Dibutyl phthalate (DBP) is widely used as plasticizer in numerous kinds of products such as plastic packaging in food industries. There is a high risk of DBP exposure for human; it can easily migrate into the human bodies through food plastic packaging and be a potential hazard for human health. In this study the neurobehavioral effects of oral DBP for 14 days (6.25, 12.5, 25, 50, 100 and 200 mg/kg) were investigated in mice, using open field, Y-maze, elevated plus maze, passive avoidance test, rotarod and grip strength test. The results showed that DBP could reduce total distance movement, impair memory function and induce anxiety in mice. Histological analysis (haematoxylin-eosin staining) also showed significant nuclei size reduction and condensation in dentate gyrus cells of the DBP treated mice. In conclusion oral DBP administration for 14 days may cause some neurobehavioral adverse effects in mice.
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In rodents, DBP impairs memory performance, reduces motor activity, and induces anxiety-like behavior.
“In rodents, DBP impairs memory performance, reduces motor activity, and induces anxiety-like behavior (Farzanehfar et al., 2016), while DINP similarly causes anxiety and cognitive deficits (Ma et al., 2015).”
From Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction (2026) · cites this paper as Farzanehfar et al., 2016
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Seralini, G.-E., & Jungers, G. (2021) · Toxicology Reports · doi:10.1016/j.toxrep.2021.07.014 · Cited by 57 · see citing works
Jocsak, G., Kiss, D. S., Alymbaeva, D., Diebald, A., Zsarnovszky, A., Heinzlmann, A., & Bartha, T. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1821381 · Cited by 1 · see citing works
“In rodents, DBP impairs memory performance, reduces motor activity, and induces anxiety-like behavior (Farzanehfar et al., 2016), while DINP similarly causes anxiety and cognitive deficits (Ma et al., 2015).”
- Authors
- Farzanehfar, V., Naderi, N., Kobarfard, F., & Faizi, M.
- Affiliations
- Shahid Beheshti University (IR)
- Corresponding author
- Faizi, Mehrdad
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 94
- Pages
- 221-226
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2443924634
- Cited by
- 61
- References
- 0
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- dibutyl phthalate, neurobehavioral toxicity, plasticizers, food packaging, memory impairment, anxiety, motor coordination, grip strength, dentate gyrus, neurotoxicity, oral exposure
- MeSH terms
- Animals, Behavior, Animal, Dibutyl Phthalate, Dose-Response Relationship, Drug, Male, Nervous System, Mice
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