Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau

Tsujio, Ichiro; Zaidi, Tanweer; Xu, Jiliu; Kotula, Leszek; Grundke-Iqbal, Inge; Iqbal, Khalid

doi:10.1016/j.febslet.2004.11.097

Inhibitors of protein phosphatase‐2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau

Protein phosphatase (PP)‐2A, which regulates the phosphorylation of tau, is regulated by two endogenous inhibitor proteins, and , in mammalian tissues. Here, we report the cloning of and from human brain, and show that in PC12 cells and in or transfected NIH3T3 and human neural progenitor cells, …