Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes
Abstract
A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL. Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution.
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DOCK11 is highly expressed in B and T lymphocytes.
“DOCK11 is a CDC42-specific GEF that is highly expressed in B and T lymphocytes and has been shown to participate in B-cell homeostasis and differentiation mechanisms (94, 97, 128).”
From RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors (2021) · cites this paper as [128]
DOCK11 is a CDC42-specific GEF.
“DOCK11 is a CDC42-specific GEF that is highly expressed in B and T lymphocytes and has been shown to participate in B-cell homeostasis and differentiation mechanisms (94, 97, 128).”
From RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors (2021) · cites this paper as [128]
DOCK11 participates in B-cell homeostasis and differentiation mechanisms.
“DOCK11 is a CDC42-specific GEF that is highly expressed in B and T lymphocytes and has been shown to participate in B-cell homeostasis and differentiation mechanisms (94, 97, 128).”
From RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors (2021) · cites this paper as [128]
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References 32 · Cited by 70
- Authors
- Nishikimi, A., Meller, N., Uekawa, N., Isobe, K.-I., Schwartz, M. A., & Maruyama, M.
- Affiliations
- National Center for Geriatrics and Gerontology (JP)
- University of Virginia (US)
- Corresponding author
- Maruyama, Mitsuo
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-01-13
- Volume
- 579
- Issue
- 5
- Pages
- 1039-1046
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2123826436
- Cited by
- 70
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R0147214)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- DOCK180, Cdc42, guanine nucleotide exchange factor, Rho GTPases, germinal center B cells, lymphocytes, gene cloning, tissue distribution
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, Cloning, Molecular, Enzyme Activation, Lymphocytes, Molecular Sequence Data, Protein Binding, Substrate Specificity, Sequence Alignment, Protein Structure, Tertiary, Protein Isoforms, Guanine Nucleotide Exchange Factors, rac GTP-Binding Proteins, cdc42 GTP-Binding Protein, Gene Expression Profiling, Mice
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