Pathway information for systems biology
Open accessAbstract
Pathway information is vital for successful quantitative modeling of biological systems. The almost 170 online pathway databases vary widely in coverage and representation of biological processes, making their use extremely difficult. Future pathway information systems for querying, visualization and analysis must support standard exchange formats to successfully integrate data on a large scale. Such integrated systems will greatly facilitate the constructive cycle of computational model building and experimental verification that lies at the heart of systems biology.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pathway representations frequently use abstractions for metabolic, signaling, gene regulation, protein interaction and genetic interaction.
“Pathway representations frequently use abstractions for metabolic, signaling, gene regulation, protein interaction and genetic interaction and these serve as a starting point toward a shared language25.”
From The BioPAX community standard for pathway data sharing (2010) · cites this paper as [25]
The citation lists haven’t been fetched yet
References 54 · Cited by 152
- Authors
- Cary, M. P., Bader, G. D., & Sander, C.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2005-02-09
- Volume
- 579
- Issue
- 8
- Pages
- 1815-1820
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2161441225
- Cited by
- 152
- References
- 54
- Citations by year
- 2026: 20 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 13 · 2013: 8 · 2012: 8
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- biological pathway databases, data integration, pathway visualization, systems biology
- MeSH terms
- Animals, Humans, Models, Biological, Protein Binding, Signal Transduction, Databases, Factual, Computational Biology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
